HLA polymorphisms in a Shanghai Chinese population

Abstract

The frequencies of the HLA‐A, B, C, D, DR and MB antigens have been determined in a homogeneous Shanghai Chinese population. Comparisons with the HLA‐A and ‐B frequencies in other subsets of the Chinese population revealed some marked differences. No comparisons were possible for the D, DR and MB antigens since there were no previous studies of the antigens in those loci. We suggest that studies of the Chinese population should be confined to clearly defined homogeneous subsets. In this manner, the confounding effect of population heterogeneity may be avoided, and it is this heterogeneity which calls for extensive surveys of the huge Chinese population.

HLA polymorphisms in a Han Chinese population of Sichuan

“…Table 7 lists the hapolotype frequencies with significant linkage disequilibrium between two HLA loci. In addition to haplotypes A30-Bl3, A2-Bw46, Aw33-Bl7, Bw60-Cw7, Bw54-Cw1, B35-Cw4, B17-DR3 which have statistically significant gametic associations, (these are also the cases in previous reports (Jaraquemada et al 1984, Miniter et al 1981), our study also shows the haplotypes B7-Cw7 and B39-Cw7 to have significant link-age disequilibrium in the Japanese as well ). However, we found the Chinese haplotype Bw46-DRw9 to have a significant association other than Japanese, in which the DR antigen often linked together with Bw46 is DRw8 (Matsuyama et al 1981).…”

“…Since the typing sera of anti-DQw2 specificity were absent, DQw2 have not been detected. The gene frequencies of DQwl and DQw3 (formerly MBl and MB3) are 0.3513 and 0.4661, respectively, and are higher than frequencies of the Shanghai population (Jaraquemada et al 1984). The HLA-DQ locus blank gene frequency including DQw2 was 0.1826, therefore it provided the evidence that DQw2 antigen frequency was low in Sichuan Chinese.…”

“…The frequencies of the new splits of DR locus antigens DRw12(5) and DRw13(w6) are high. Concerning the antigen DRwlO, in the mainland Chinese populations it was rarely reported (Jaraquemada et al 1984). In the present study, the frequency of DRwlO was 1.4%.…”

“…There are more than 100 million inhabitants living in this province and the majority of them is Han Chinese. As yet there has been little information concerning the distribution of HLA polymorphisms of Chinese (Jaraquemada et al 1984, Chan et al 1979, Miniter et al 1981) and this is not from the Sichuan population.…”

HLA‐B15 heterogeneity in different populations

“…Figures 1 and 2 show the pedigrees of the two families "J" and "S" segregating for B15G. B15SL1 was described in a study in which 65 unrelated Chinese and 3 Chinese families were HLA-typed (Jaraquemada et al 1984). This antigen was found in one of the families (Figure 3) and the antigen frequency in the unrelated population was 10%.…”