HLA matching for kidney transplantation

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“…By analyzing large databases, many investigators have found that recipients of HLA-matched kidneys experience superior outcomes, as defined by lower rates of rejection and higher rates of graft and patient survival, than recipients of HLA-mismatched kidneys. 15 Furthermore, multifactorial analysis of 1252 pediatric deceased-donor renal transplants performed in the United Kingdom and Ireland between 1986 and 1995 also revealed that HLA matching was 1 of the most important determinants of outcome. 16 A previous retrospective analysis was performed with data from the Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients to examine the effect of HLA-DR matching on allograft survival and sensitization rates in children receiving kidneys from deceased donors.…”

Investigation of Human Leucocyte Antigen Epitopes in Organ Transplantation: Review

“…Programın ilk sürümü üçlü aminoasit dizi uyumsuzluğu [triplet mismatch (tmm)] olarak adlandırılır ve HLA Sınıf I moleküllerine odaklanmıştır (Şekil 1). 12,13 Bunun sebebi, HLA Sınıf I molekülleri tarafından uyarılan T-sitotoksik hüc-relerin immün reaksiyonlarının immünsupresif ilaç tedavileri ile kontrol altına alınamamasından kaynaklanmaktadır. HLA Sınıf I moleküllerinin immün reaksiyondaki rolünü saptamak için molekülün antikor ile etkileşen rezidüleri X ışını kristalografi çalışmaları ile saptanmıştır.…”

Characteristics, Detection, and Clinical Relevance of Alloantibodies in Kidney Transplantation

“…In kidney transplantation, graft outcomes critically depend on the degree of HLA matching between the donor and recipient (Abe et al, 1997;Akalin & Pascual, 2006;Balan et al, 2008;Bas et al, 1998;Claas et al, 2005;Scornik et al, 1992;Takemoto et al, 2004;Terasaki 2003;). Although the cellular component of the allogenic immune response to the transplanted tissue plays a key role in this matching, the contribution of antibodies should not be underestimated Bartel et al, 2007;Stegall et al, 2009;Sumitran-Holgersson, 2001;Vasilescu et al, 2004;Zeevi et al, 2009).…”

“…Numerous clinical studies since the 1990s have demonstrated various strategies for identifying donors for high PRA patients. Rodey's and Takemoto's groups have reported successful kidney graft outcomes and negative cross-matching when HLA matching was performed using cross-reactive groups (CREG) and/or public epitopes (Rodey & Fuller, 1987;Takemoto, 1995Takemoto, , 2004). Terasaki's method for analyzing donor and recipient compatibility applies the amino acid sequencing of HLA alleles Deng, 2008;El-Awar et al, 2005, 2006a, 2006bEl-Awar & Terasaki, 2007).…”