“…Among these studies, 18 studies provided multivariable-adjusted effect estimates [ 19 , 21 – 24 , 27 – 39 ], 3 studies provided both multivariable-adjusted and univariable-unadjusted data [ 20 , 25 , 26 ], and 2 studies provided univariable-unadjusted data [ 40 , 41 ]. Besides, 8 studies were multi-centered [ 19 , 23 , 27 , 32 , 33 , 35 , 37 , 38 ]; another 15 studies were single-centered [ 20 – 22 , 24 – 26 , 28 – 31 , 34 , 36 , 39 – 41 ]. When considering HLA locus as categories, 11 studies reported survival outcomes of all HLA locus (HLA-A, -B and -DR) [ 20 , 23 – 28 , 32 , 35 , 36 , 40 ], 8 [ 19 , 20 , 22 , 29 – 31 , 33 , 41 ] reported HLA-DR locus, 4 with HLA-B locus [ 19 , 30 , 31 , 33 ], and 3 with HLA-A locus [ 30 , 31 , 33 ].…”