1978
DOI: 10.1016/s0140-6736(78)90178-2
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Hla in Cryptogenic Fibrosing Alveolitis

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Cited by 38 publications
(18 citation statements)
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“…The association between pulmonary fibrosis and HLA genes has been examined in several studies. Association with the HLA class I genes B7, B8 and B12 and the HLA class II gene DR2 was inconsistently found and not confirmed by published studies [118][119][120][121].…”
Section: Pulmonary Fibrosismentioning
confidence: 76%
“…The association between pulmonary fibrosis and HLA genes has been examined in several studies. Association with the HLA class I genes B7, B8 and B12 and the HLA class II gene DR2 was inconsistently found and not confirmed by published studies [118][119][120][121].…”
Section: Pulmonary Fibrosismentioning
confidence: 76%
“…Because of the very strong LD within this haplotype, it is difficult to precisely identify the particular disease-associated HLA allele among them, or distinguish the contributions of these HLA from other interspersed immunoregulatory elements, in lieu of focused, high-resolution genomic studies [21,38,39]. Almost all previous HLA characterizations of IPF patients date from before the development of precise and definitive molecular methodologies that distinguish these alleles [40][41][42][43][44][45] (Table 4). Moreover, only two of these early serologic-based determinations examined even a very restricted repertoire of the many, sincediscovered, Class II alleles [44,45].…”
Section: Discussionmentioning
confidence: 99%
“…The numbers of subjects among those investigations were also usually quite small (Table 4), severely limiting their power to detect intergroup differences. Despite these potential limitations, however, several of those earlier investigations indicated HLA allele frequency perturbations may be present in IPF [40,[43][44][45], although this finding was not invariable [41,42]. In particular, one of these earlier studies indicated that DR2, a serologic correlate of HLA-DRB1*15 and, generally much less frequently, HLA-DRB1*16 gene products, appeared to be over-represented in IPF subjects (45), a finding which may be congruent with the current results.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, however, patient 1 with the most severe lung disease showed expression of HLA B7, and this antigen has been implicated to play a role in cryptogenic fibrosing alveolitis. 19 This may have made her more susceptible to the antigens than her siblings. Whether the HLA-typing of the father results in protection against PBL remains unknown, because he probably experienced less antigen exposure than the children.…”
Section: Discussionmentioning
confidence: 99%