2016
DOI: 10.1186/s12969-016-0086-4
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HLA II class alleles in juvenile idiopathic arthritis patients with and without temporomandibular joint arthritis

Abstract: BackgroundTemporomandibular joint (TMJ) arthritis is seen very often (38–87 %) in children with juvenile idiopathic arthritis (JIA). With contrast enhanced magnetic resonance imaging (MRI) we can detect more cases of TMJ arthritis than ever before. Previous studies show that HLA II class alleles may have protective or risk importance in JIA subtypes. Our objective is to identify HLA II class alleles of risk and protection in JIA patients with TMJ arthritis.MethodsDuring the period from 2010 to 2015 MRI for TMJ… Show more

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Cited by 4 publications
(7 citation statements)
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“…Different classes of the human leucocyte antigen ( HLA ) have also been studied in regard to TMD. Apparently, HLA‐DRB1*01 (associated with joint erosions), DR54 and DR11 alleles (associated with a higher susceptibility to degenerative process), and DR54 and DR52 alleles (associated with a higher severity of degenerative process) are risk factors for TMD . Conversely, DRB1*12:01 , DQB1*03:01 , DRB1*06 , DQA1*05:01 and HLA‐B27 alleles appear to protect against temporo mandibular joint (TMJ) arthritis …”
Section: Discussionmentioning
confidence: 99%
“…Different classes of the human leucocyte antigen ( HLA ) have also been studied in regard to TMD. Apparently, HLA‐DRB1*01 (associated with joint erosions), DR54 and DR11 alleles (associated with a higher susceptibility to degenerative process), and DR54 and DR52 alleles (associated with a higher severity of degenerative process) are risk factors for TMD . Conversely, DRB1*12:01 , DQB1*03:01 , DRB1*06 , DQA1*05:01 and HLA‐B27 alleles appear to protect against temporo mandibular joint (TMJ) arthritis …”
Section: Discussionmentioning
confidence: 99%
“…Additional gene associations include: HLA-DRB1*01 (human leucocyte antigen) DRB1 allele with joint erosions, DR54 and DR11 alleles with higher susceptibility to degenerative process, and DR54 and DR52 alleles with a higher severity of degenerative process. These identified alleles are all associated with risk factors for developing TMDs (21,22). Contrarily, other variants including DRB1*12:01, DQB1*03:01, DRB1*06, DQA1*05:01, and HLA-B27 have been shown to be protective against temporomandibular joint (TMJ) arthritis (21,22).…”
Section: Tmdsmentioning
confidence: 99%
“…These identified alleles are all associated with risk factors for developing TMDs (21,22). Contrarily, other variants including DRB1*12:01, DQB1*03:01, DRB1*06, DQA1*05:01, and HLA-B27 have been shown to be protective against temporomandibular joint (TMJ) arthritis (21,22).…”
Section: Tmdsmentioning
confidence: 99%
“…Insbesondere in frühen Erkrankungsstadien, aber auch bei fortgeschrittener Kiefergelenkarthritis, fehlen oftmals subjektiv wahrgenommene und klinische Auffälligkeiten (Cedströmer et al 2014, Svensson et al 2001. Die Untersuchung muss sehr sorgfältig und präzise erfolgen, wobei rheumaspezifische Anamnese-und Untersuchungsbögen verwendet werden sollten (Dāvidsone et al 2016, Kahl-Nieke 2013, Hiz et al 2012. Die klinische Diagnostik alleine ist allerdings nicht ausreichend kondyläre Veränderungen zu diagnostizieren (Hu et al 2009).…”
Section: Medikationunclassified
“…Das MRT gilt in der Kiefergelenksdiagnostik als Goldstandard, wobei ein bedeutender Nachteil in der notwendigen Sedierung der jungen Patienten liegt (Cedströmer et al 2014, Argyropoulou et al 2009, Twilt et al 2008. Zur Evaluation starker Diagnostikparameter zählen neben anamnestischen und klinischen Auffälligkeiten auch weitere Parameter, wie Erkrankungsart und -aktivität, Patientenalter, Blutparameter und genetische Aspekte (Dāvidsone et al 2016, Niibo et al 2016, Keller et al 2015, Cedströmer et al 2014, Abramowicz et al 2013, Koos et al 2011, Argyropoulou et al 2009, Weiss et al 2008, Billiau et al 2007, Twilt et al 2004 Die Folge dieser Erkrankungen ist eine zunehmende Organinsuffizienz (Isenberg et al 2004). Das MAS ist eine wenn auch seltene aber lebensbedrohliche Komplikation (Reutter und Girschick 2013).…”
Section: Medikationunclassified