1992
DOI: 10.1007/bf00400926
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HLA haplotypes in Type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus

Abstract: In Caucasians the predisposition to Type 1 (insulin-dependent) diabetes mellitus has been shown to associate with HLA-DR3,DQw2 and DR4,DQw8 and with the presence of amino acids other than aspartic acid at position 57 on the HLA-DQ beta chain. In Finland the haplotype-specific absolute risk for developing Type 1 diabetes differs between various DR3 and DR4 positive haplotypes. The aim of our present analysis was to find out whether this variation is attributable to polymorphism at the DQ locus. As part of a nat… Show more

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Cited by 36 publications
(29 citation statements)
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“…Alterations in fetal growth are known to associate with T1D in various ways. 9 Our finding is particularly interesting, since we show that the [B56,DR4] haplotype, which strongly increases the T1D risk in Finland, but has not been found in T1D patients outside this country, 5,6 is associated with high BW. At the present, we do not have data on BW in non-diabetic individuals without a family history of T1D who carry the [B56,DR4] haplotype.…”
Section: Based On Thementioning
confidence: 64%
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“…Alterations in fetal growth are known to associate with T1D in various ways. 9 Our finding is particularly interesting, since we show that the [B56,DR4] haplotype, which strongly increases the T1D risk in Finland, but has not been found in T1D patients outside this country, 5,6 is associated with high BW. At the present, we do not have data on BW in non-diabetic individuals without a family history of T1D who carry the [B56,DR4] haplotype.…”
Section: Based On Thementioning
confidence: 64%
“…The [A2,Cw1,B56,DR4,DQ8] haplotype is relatively rare in Finland, whereas the susceptibility haplotypes [B8,DR3], [B62,DR4] and [B39,DR4] are more common also in the general population. 5,6,45 Maternal age of 35 years or above is known to increase BW 32 as well as the risk of developing T1D in the offspring. 46 The proportion of parturients aged 35 years or above has increased over time and is now 19.0% in Finland.…”
Section: Based On Thementioning
confidence: 99%
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“…Recent serological and molecular typing of a large Finnish population suggests that the HLA-A alleles (MHC class I region) may be 'anchors' for disease-susceptibility haplotypes [8,9]. Finally, whilst previous studies have shown that the MHC class II association is dependent upon the age at onset of IDDM very little is known about the class I region [10][11][12][13].…”
mentioning
confidence: 99%