HLA-G susceptibility to hepatitis B infection and related hepatocellular carcinoma in the Japanese population

Okumura, Taiki; Joshita, Satoru; Yamazaki, Tomoo; Iwadare, Takanobu; Wakabayashi, Shun‐ichi; Kobayashi, Hiroyuki; Yamashita, Yūki; Sugiura, Ayumi; Kimura, Takefumi; Ôta, Masao; Umemura, Takeji

doi:10.1016/j.humimm.2023.05.002

Human Immunology

2023

DOI: 10.1016/j.humimm.2023.05.002

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HLA-G susceptibility to hepatitis B infection and related hepatocellular carcinoma in the Japanese population

Taiki Okumura

Satoru Joshita

Tomoo Yamazaki

et al.

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2024

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Cited by 1 publication

(3 citation statements)

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“…Overall, several lines of evidence suggest that the G allele and/or GG genotype of the HLA-G + 3142 C > G polymorphism was strongly associated with the susceptibility to several infectious diseases [36][37][38]. In the context of HBV infection, both the recent study by Okumura et al [35] and our current research have con rmed the following ndings. In addition, elevated levels of sHLA-G expression have been consistently reported in CHB patients across different cohorts, underscoring the important role of the HLA-G molecule in in uencing the outcome of this disease [29][30][31][32].…”

supporting

confidence: 80%

“…showing a signi cant association of the G allele with susceptibility to chronic HBV infection in the Japanese population [35]. Interestingly, our results are .…”

supporting

confidence: 52%

“…It's worth noting that we could not conclusively demonstrate this association in the progression of liver brosis within our cohort, possibly due to the limited sample size. Similarly, Okumura et al also reported a lack of correlation between HLA-G + 3142 C > G polymorphism and progression to HCC [35].…”

mentioning

confidence: 94%

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Association of HLA-G 3’UTR Polymorphisms with hepatitis B virus infection in Tunisian population

Laaribi,

Mehri,

Yahia

et al. 2024

Preprint

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Background Hepatitis B virus (HBV) infection is a major public health burden. The mechanisms of immune evasion during chronic HBV (CHB) infection are poorly understood. Human leukocyte antigen (HLA)-G, an immune checkpoint molecule, plays a crucial role in the tolerance mechanisms of various infectious diseases. The 3’untranslated region (3’UTR), including the HLA-G + 3142C > G polymorphism (rs1063320) and the 14-pb Ins/Del (rs66554220) has been strongly suggested to influence HLA-G expression. Objective This study conducted a case-control analysis to evaluate the potential correlation between the HLA-G + 3142 C > G polymorphism and HBV infection outcome in a Tunisian cohort. Methods The HLA-G + 3142C > G polymorphism was analysed by PCR-RFLP in 242 patients with chronic HBV infection, 241 healthy controls, and 100 spontaneously resolved subjects. Results Patients with chronic HBV infection showed a higher frequency of the + 3142 G allele compared to healthy controls and spontaneously resolved subjects (p = 0.001 and p = 0.002, respectively). An association between the + 3142 G allele and high HBV DNA levels was observed when HBV patients were stratified based on their HBV DNA levels (p = 0.016). Furthermore, the dominant model (GG + GC vs CC) was associated with liver function parameters, including AST, ALT, and high HBV DNA levels (p = 0.04, p < 0.001 and p = 0.002, respectively). However, there was no significant association found between this polymorphism and the fibrosis stage (p = 0.32). The haplotype analysis, using a subset of previously published data on the HLA-G 14pb Ins/Del polymorphism, revealed an association between the Ins/G haplotype and chronic HBV infection (H1: InsG, p < 0.001). Conclusion Our findings suggest that the + 3142 G allele is a risk factor for the persistence and progression of HBV infection, while the + 3142 C allele serves as a protective allele associated with the spontaneous resolution of the infection. Additionally, the HLA-G 3’UTR haplotype Ins/G is associated with chronic HBV infection in the Tunisian population.

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supporting

confidence: 80%

“…showing a signi cant association of the G allele with susceptibility to chronic HBV infection in the Japanese population [35]. Interestingly, our results are .…”

supporting

confidence: 52%

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Association of HLA-G 3’UTR Polymorphisms with hepatitis B virus infection in Tunisian population

Laaribi,

Mehri,

Yahia

et al. 2024

Preprint

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HLA-G susceptibility to hepatitis B infection and related hepatocellular carcinoma in the Japanese population

Cited by 1 publication

References 30 publications

Association of HLA-G 3’UTR Polymorphisms with hepatitis B virus infection in Tunisian population

Association of HLA-G 3’UTR Polymorphisms with hepatitis B virus infection in Tunisian population

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