HLA-G High-expressor 3’UTR Markers Are Linked to Gastric Cancer Development and Survival
Christian Vaquero-Yuste,
Ignacio Juarez,
Marta Molina-Alejandre
et al.
Abstract:Gastric cancer ranks fifth in both world prevalence and lethality, with a 5-year survival of less than 30%. HLA-G, a non-classical class I HLA gene, has emerged as a potential marker for cancer susceptibility and prognosis due to its immunomodulatory properties. Its level of expression is regulated by polymorphisms in the 3’ untranslated region (3’UTR) polymorphisms, which form various combined haplotypes (UTR-1 to -9). In this study, we examined HLA-G 3’UTR polymorphisms in paired tissue samples from 111 pati… Show more
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