HLA-G expression is induced in Epstein-Barr virus–transformed B-cell lines by culture conditions

Gazit, Ephraim; Sherf, Maya; Balbin, Elkana; Muratov, Anna; Goldstein, Itamar; Loewenthal, Ron

doi:10.1016/j.humimm.2007.02.009

Cited by 19 publications

(14 citation statements)

References 23 publications

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“…IAV infection can be considered as a stressfull condition by the cell, which can turn on HLA-G transcription and protein expression. These results are in accordance with recent reports suggesting that HLA-G could be an important factor during infection as a mechanism used by viruses to evade from immunosurveillance [14]. In this regard, herpes simplex virus type 1, rabies virus, as well as human immunodeficiency virus type 1 were previously described as inducing HLA-G expression in neurons and T cells, respectively [15][16][17].…”

Section: Discussionsupporting

confidence: 93%

“…In this regard, we have previously shown that HLA-G plays a fundamental role in maternal-fetal tolerance [12,13]. Recently evidence was provided that HLA-G is an important factor during infection [14]. In this context, herpes simplex virus type 1 and rabies virus as well as human immunodeficiency virus type 1 induce HLA-G expression in neurons and T cells, respectively [15][16][17].…”

Section: Introductionmentioning

confidence: 97%

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Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection

et al. 2009

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 97%

Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection

et al. 2009

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“…Certain viruses may downregulate major histocompatibility complex class I molecules by producing peptides homologous to HLA class I leader peptides, thus allowing the virus to escape natural killer immune surveillance. The role of HLA-G has been discussed in tissue or cultured cells infected with HIV, rabies, herpes simplex, human cytomegalovirus, and H1N1 [10,11,18,19].…”

Section: Discussionmentioning

confidence: 99%

Upregulation of soluble and membrane-bound human leukocyte antigen G expression is primarily observed in the milder histopathological stages of chronic hepatitis C virus infection

et al. 2012

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“…22 Although removal of the 92 bases produces a more stable mRNA, the presence of þ 14 bp has been associated with a lower mRNA production. 20 Some virus including Epstein-Barr virus, rabies virus and cytomegalovirus may upregulate HLA-G expression; 13,[23][24][25] however, the function of HPV in HLA-G expression has not been determined. Recently, we reported that cervical lesions may express HLA-G molecules that may differ according to the severity of SIL in HPV-infected women.…”

Section: -15mentioning

confidence: 99%

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

et al. 2009

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Human papillomavirus (HPV) infection is etiologically associated with low-(LSIL) and high-grade squamous intraepithelial lesions (HSIL) and with cervical cancer. The progression or regression of the lesions may depend, among other factors, on the host heritable immune response. Because human leukocyte antigen (HLA)-G molecules are involved in the modulation of innate and adaptive immune responses, and because no previous studies have evaluated HLA-G polymorphism in patients with SIL, we conducted a study to assess the association between HLA-G polymorphisms and cervical lesions harboring HPV infection. Cervico-vaginal scrapings and blood samples were collected from 125 women with SIL (68 LSIL and 57 HSIL) and from 94 healthy women without HPV infection and cytological abnormalities. HPV type and HLA-G polymorphisms in exons 2, 3 and 8 (14 bp insertion/deletion) were evaluated by PCR methodology, and digested with restriction endonucleases. The Genepop software and the EM and PHASE algorithms were used for statistical analysis. A significant protective association was observed between the presence of the G*0103 allele and SIL and between the G0101/G0104 genotype and HSIL in the group of patients compared to control. The presence of the G0104/ þ 14 bp and G0104/À14 bp haplotypes conferred susceptibility to SIL compared to control. In addition, patients possessing the G0104/ þ 14 bp haplotype and harboring HPV-16 and -18 co-infections were particularly associated with HSIL. These findings suggest that HLA-G polymorphisms may be associated with HPV infection and SIL, consequently representing a profile of predisposition to cervical cancer.

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HLA-G expression is induced in Epstein-Barr virus–transformed B-cell lines by culture conditions

Cited by 19 publications

References 23 publications

Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection

Immunosuppressive HLA-G molecule is upregulated in alveolar epithelial cells after influenza A virus infection

Upregulation of soluble and membrane-bound human leukocyte antigen G expression is primarily observed in the milder histopathological stages of chronic hepatitis C virus infection

HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus

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