HLA-G Dimers in the Prolongation of Kidney Allograft Survival

Ezeakile, Maureen; Portik-Dobos, Vera; Wu, Juan; Horuzsko, Daniel D.; Kapoor, Rajan; Jagadeesan, Muralidharan; Mulloy, Laura L.; Horuzsko, Anatolij

doi:10.1155/2014/153981

Cited by 21 publications

(19 citation statements)

References 50 publications

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“…Many studies observed that higher serum HLA-G level or HLA-G mRNA expression is associated with kidney graft acceptance [8,18,[20][21][22][23]26,31]. The authors have suggested that soluble HLA-G could be used as additional marker to monitor the graft acceptance outcome.…”

Section: Discussionmentioning

confidence: 99%

“…In kidney transplant patients, increased soluble HLA-G level was significantly associated with better graft acceptance [8,18,[20][21][22][23]. As the expression of sHLA-G may be influenced by the 14 bp insertion polymorphism [15], the possible association between this variant and graft acceptance has been investigated, but the results are controversial.…”

Section: Genotyping Of Hla-g 14 Bp Polymorphism At Exon 8 (3´ Utr)mentioning

confidence: 99%

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Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Ďurmanová

Bandžuchová²,

Žilinská

et al. 2016

Open Life Sciences

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Human leukocyte antigen G (HLA-G) is a non-classical HLA class I protein with various immunosuppressive functions. Besides its profound effect to induce fetal tolerance, HLA-G has been also found to enhance graft acceptance. The aim of the study was to analyse the association between HLA-G 14 bp insertion/deletion polymorphism, soluble HLA-G level and kidney graft outcome in the Slovak population. We investigated 69 kidney transplant recipients aged 27–65 years. Out of this group, 37 recipients developed acute rejection, confirmed by biopsy, and 32 patients had stable allograft function. Plasma was obtained from recipients at 1 day before transplantation and analyzed by ELISA. Genotyping of HLA-G polymorphism was performed by PCR. Significantly higher pre-transplantation levels of sHLA-G were found in the group with stable allograft function in comparison to group with acute rejection (P = 0.0409). In the homozygous −14/−14 recipients with stable allograft function, significantly higher values of sHLA-G were determined in comparison to the recipients with acute rejection (P = 0.0052). The study revealed an association between 14 bp deletion polymorphism and soluble HLA-G level that is proportional to kidney graft acceptance. It is suggested that pre-transplantation levels of soluble HLA-G should be monitored as additional marker to predict kidney graft outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Genotyping Of Hla-g 14 Bp Polymorphism At Exon 8 (3´ Utr)mentioning

confidence: 99%

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Ďurmanová

Bandžuchová²,

Žilinská

et al. 2016

Open Life Sciences

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“…In this study, the investigators evaluated the levels of sHLA-G1 and HLA-G5 dimers and monomer isoforms. In confirmation of their finding, the increased cellsurface expression of HLA-G on monocytes of patients with no rejection episodes was found to be associated with high levels of plasma sHLA-G dimers [100]. These observations underscore the potential of HLA-G in graft acceptance; but it remains to be determined whether this potential is due to cell-surface expression of HLA-G1 or whether its soluble form, HLA-G5, induces graft acceptance in the course of its specific mechanism of action.…”

Section: Immunobiology Of Soluble Hla-ib In Transplantationmentioning

confidence: 54%

Immunobiology of HLA Class-Ib Molecules in Transplantation

Jucaud¹

2015

SOJI

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“…Indeed the recent article published 2014, addressing the role of HLA-G dimers in the prolongation of kidney allograft survival supports this concept. 16 …”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

Exp Clin Transplant

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Objectives: Studying immune tolerance induced by HLA-G in kidney allograft acceptance may help understanding of its mechanisms, hoping in the future to boaster it and decrease the immunosuppressive drugs given that are well known to have serious adverse effects. Materials and Methods: The current study sought to evaluate soluble HLA-G in 3 groups: kidney transplanted patients with no rejection episodes, transplanted patients with biopsy-proven renal rejection, and healthy age-matched non transplanted individuals.Three groups were studied: kidney transplanted patients with no rejection episodes (n = 43); transplanted patients with biopsy-proven renal rejection (n = 27); healthy, age-matched, nontransplanted individuals as controls (n = 42). Soluble HLA-G level was measured in the serum by a quantitative sandwich enzyme linked immunosorbent assay. Results: sHLAG level was significantly higher in the transplanted patients compared with the control. Prograf and not cyclosporine or Rapamune had positive effects on sHLAG levels. Patients with chronic rejection had a significant lower level of sHLAG compared with a graft stable group. No effect of donor type, infection or duration posttransplant, on sHLAG levels was found. Conclusions:The results of the current study are consistent with previous studies addressing the role of sHLAG in inducing immunotolerance postkidney transplant. The findings from the current study on the chronic rejection group, supports the on-going research of having a treatment with HLA-G/or derivate, which may constitute in the future a novel efficient anti-graft rejection therapy.

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HLA-G Dimers in the Prolongation of Kidney Allograft Survival

Cited by 21 publications

References 50 publications

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Impact of HLA-G 14 bp polymorphism and soluble HLA-G level on kidney graft outcome

Immunobiology of HLA Class-Ib Molecules in Transplantation

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