HLA-G 14 bp insertion/deletion polymorphism and its association with sHLA-G levels in Behçet’s disease Tunisian patients

Sakly, K.; Maatouk, M.; Hammami, S.; Harzallah, O.; Sakly, Wahiba; Feki, S.; Mirshahi, Massoud; Ghedira, Ibtissem; Sakly, Nabil

doi:10.1016/j.humimm.2015.10.016

Cited by 11 publications

(12 citation statements)

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“…In general, the 14 bp Ins/Ins was associated with significantly lower sHLA-G level in plasma or serum (Chen et al, 2008;Hviid et al, 2004;Inès et al, 2015;Rizzo et al, 2013;Twito et al, 2011). However, Sakly et al (2015) showed that there was no association between HLA-G 14 bp polymorphism and sHLA-G plasma level in Tunisian patients with…”

Section: Discussionmentioning

confidence: 96%

“…In general, the 14 bp Ins/Ins was associated with significantly lower sHLA‐G level in plasma or serum (Chen et al, ; Hviid et al, ; Inès et al, ; Rizzo et al, ; Twito et al, ). However, Sakly et al () showed that there was no association between HLA‐G 14 bp polymorphism and sHLA‐G plasma level in Tunisian patients with Behcet's disease. Our results showed an association between the presence of the Ins/Ins genotype and low sHLA‐G level in the OSCC patients.…”

Section: Discussionmentioning

confidence: 99%

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Human leucocyte antigen‐G 14‐bp InDel polymorphism and oral squamous cell carcinoma risk in Chinese Han population: A case–control study

Wang

Zhao

Liu

et al. 2018

Int J Immunogenetics

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Human leucocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule involved in tumour immune escape. The purpose of this study was to investigate the association between the 14-bp insertion/deletion (InDel) polymorphism in the 3' untranslated region (3'-UTR) of HLA-G gene and oral squamous cell carcinoma (OSCC) risk in Chinese Han population (216 cases and 193 healthy controls), and furthermore, to evaluate serum soluble HLA-G (sHLA-G) levels in the OSCC patients. Our results demonstrated that the Ins allele was significantly less frequent in the OSCC patients than that in the healthy controls (odds ratio [OR] = 0.75; 95% confidence interval [CI]: 0.57-0.99; p = 0.040). Distribution of the 14-bp genotypes in the OSCC patients and the healthy controls revealed that the Ins/Ins genotype was associated with decreased OSCC risk in both the codominant model (Ins/Ins versus Del/Del; OR = 0.57; 95% CI = 0.33-0.99; p = 0.044) and the log-additive model (OR = 0.76; 95% CI: 0.58-0.99; p = 0.044). The serum sHLA-G level was significantly higher in the OSCC patients than those in the healthy controls (p < 0.001). Receiver operating characteristic (ROC) curve revealed the valuable diagnostic value of sHLA-G for OSCC detection, with an area under the ROC curve (AUC) of 0.891 (95% CI: 0.856-0.925, p < 0.001). The OSCC patients with Ins/Ins genotype had lower serum sHLA-G levels than those with Ins/Del and Del/Del genotypes (p = 0.015). Furthermore, serum sHLA-G levels were significantly increased with the increasing TNM stages of the OSCC patients (p = 0.017). Our findings revealed that the HLA-G 14-bp InDel polymorphism might be a genetic risk factor for OSCC susceptibility, and the serum sHLA-G may act as a promising biomarker for noninvasive diagnosis of OSCC.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Human leucocyte antigen‐G 14‐bp InDel polymorphism and oral squamous cell carcinoma risk in Chinese Han population: A case–control study

Wang

Zhao

Liu

et al. 2018

Int J Immunogenetics

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“…As in other world populations, both alleles (Ins and Del) showed polymorphic frequencies in the Iraqi sample of controls (41 and 59%, respectively). In most of the populations investigated (Table 4), Ins was the allele of minor frequency and had a range of 23.6% in Koreans [31] to 49.2% in Saudi Arabians [34] and Turkish [37]; however, Egyptians [25] and Tunisians [36] showed the opposite profile, and the Ins allele frequency exceeded this range (60 and 51.2%, respectively). Therefore, the Iraqi Ins allele frequency fits well the presented range.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility role of soluble HLA-G and HLA-G 14-bp insertion/deletion polymorphism in inflammatory bowel disease

Abdul-Hussein

Ali

Al-Khalidi

et al. 2020

Egypt J Med Hum Genet

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Background Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders of the gastrointestinal tract. It is fundamentally related to a dysregulated immune response in the intestinal mucosa against microbiota in genetically predisposed individuals. Among the genetic and immunological factors that are suggested to have role in etiology and pathogenesis of IBD are human leukocyte antigen (HLA)-G molecules. Therefore, soluble HLA-G (sHLA-G) serum level and genetic association with HLA-G 14-bp insertion (Ins)/deletion (Del) polymorphism was analyzed in 100 IBD patients; 50 ulcerative colitis (UC) and 50 Crohn’s disease (CD), and 100 controls. Results sHLA-G level was significantly elevated in IBD patients compared to controls (174.7 ± 27.1 vs. 126.8 ± 15.1; corrected probability [pc] < 0.001). The level was also elevated in UC patients compared to CD patients but the difference was not significant (180.5 ± 27.1 vs. 168.9 ± 26.3; p = 0.059). Receiver operating characteristic analysis confirmed the significance of sHLA-G in total IBD, UC, and CD patients (area under curve = 0.944, 0.961, and 0.927, respectively). The genetic association was analyzed under five genetic models (allele, recessive, dominant, overdominant, and codominant). At the allele level, Del allele frequency was significantly increased in total IBD patients (Odds ratio [OR] = 1.93; 95% confidence interval [CI] = 1.27–2.94; pc = 0.018) and CD patients (OR = 2.08; 95% CI = 1.23–3.54; pc = 0.042) compared to controls. Among UC patients, a similar increased frequency was observed, but the pc value was not significance (OR = 1.79; 95% CI = 1.07–3.00; p = 0.031). At the genotypic level, Del/Del genotype was associated with a significantly increased IBD-risk in total patients under codominant model (OR = 4.06; 95% CI = 1.56–10.56; pc = 0.024). sHLA-G level was not influenced by the Ins/Del polymorphism. Conclusions This study demonstrated a significant increase in serum level of sHLA-G in UC and CD patients. Further, HLA-G 14-bp Ins/Del polymorphism may be associated with susceptibility to IBD, particularly CD.

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“…A study by Sakly et al revealed that the HLA-G 14 bp ins/del polymorphism appears to be related to BD, as the incidence of the 14 bp allele is higher in patients compared to healthy controls. In addition, higher plasma levels of sHLA-G during active BD have also been found [126]. The researchers concluded that the different alleles of HLA-G genes have different effects on the risk of developing BD-the HLA-G* allele 01:01:01 is associated with a reduced risk of developing BD, while HLA-G* alleles 01:01:02 and G*01:05N are associated with an increased risk of developing BD [127,128].…”

Section: The Role Of Hla-g In the Development Of Systemic Lupus Eryth...mentioning

confidence: 98%

The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases

Zaborek-Łyczba

Łyczba

Mertowska

et al. 2021

IJMS

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The human G-leukocyte antigen (HLA-G) molecule is a non-classical major histocompatibility complex (MHC) class I molecule. The pertinence of HLA-G has been investigated in numerous studies which have sought to elucidate the relevance of HLA-G in pathologic conditions, such as autoimmune diseases, cancers, and hematologic malignancies. One of the main goals of the current research on HLA-G is to use this molecule in clinical practice, either in diagnostics or as a therapeutic target. Since HLA-G antigens are currently considered as immunomodulatory molecules that are involved in reducing inflammatory and immune responses, in this review, we decided to focus on this group of antigens as potential determinants of progression in autoimmune diseases. This article highlights what we consider as recent pivotal findings on the immunomodulatory function of HLA-G, not only to establish the role of HLA-G in the human body, but also to explain how these proteins mediate the immune response.

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HLA-G 14 bp insertion/deletion polymorphism and its association with sHLA-G levels in Behçet’s disease Tunisian patients

Cited by 11 publications

References 66 publications

Human leucocyte antigen‐G 14‐bp InDel polymorphism and oral squamous cell carcinoma risk in Chinese Han population: A case–control study

Human leucocyte antigen‐G 14‐bp InDel polymorphism and oral squamous cell carcinoma risk in Chinese Han population: A case–control study

Susceptibility role of soluble HLA-G and HLA-G 14-bp insertion/deletion polymorphism in inflammatory bowel disease

The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases

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