HLA Frequency in Patients With Recurrent Acute Otitis Media

Kalm, Olof; Johnson, Ulf; Prellner, Karin; Ninn, Kirsten

doi:10.1001/archotol.1991.01870230112019

Cited by 35 publications

(17 citation statements)

References 22 publications

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“…The sample sizes in these studies were small, and the appropriateness of case selection has been questioned. A relationship between the frequencies of certain HLA antigens and OM was investigated by Kalm et al [37,38]. They found a significant correlation between the frequency of HLA-A2 and HLA-A3 antigens and recurrent AOM.…”

Section: Immune Mechanismsmentioning

confidence: 99%

The genetics of otitis media

Casselbrant

Mandel

2001

Curr Allergy Asthma Rep

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There is significant evidence from epidemiologic, anatomic, physiologic, and immunologic studies that susceptibility to recurrent episodes of acute otitis media (OM) and persistent OM with effusion is largely genetically determined. The genetics of OM are most likely complex, i.e., many genes are probably contributing to the overall phenotype. The knowledge of a hereditary component has important implications because closer surveillance of children at risk for OM could result in earlier detection and treatment. Further, once OM susceptibility genes have been identified it may be possible to develop molecular diagnostic assays that could enable the clinician to identify the child at high risk for OM and to develop more focused treatments in the future.

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Section: Immune Mechanismsmentioning

confidence: 99%

The genetics of otitis media

Casselbrant

Mandel

2001

Curr Allergy Asthma Rep

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“…3 · 4 Family studies reveal that children whose siblings or parents have a history of recurrent acute otitis media (rAOM) are themselves at increased risk for developing rAOM. 2 Finally, results from a clinical study 5 indicate a relationship between rAOM and the HLA-A locus. Specifically, the following antigen levels were compared between 45 children with rAOM and a healthy control group: 8 HLA-A, 15 HLA-B, 5 HLA-C, and 6 HLA-DR.…”

Section: Introduction Otitis Media Is a Common Disease In Childrenmentioning

confidence: 99%

Distribution and Heritability of Recurrent Ear Infections

Kværner¹,

Harris²,

Tambs³

et al. 1997

Ann Otol Rhinol Laryngol

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The distribution of recurrent ear infections was obtained from a population-based sample of 2,750 pairs of Norwegian twins born between 1967 and 1974. The lifetime prevalence of self-reported recurrent ear infections was 8.9%, with a significant predominance of female cases. The mean age of onset was 4.2 years, with a gradual decrease in occurrence from 2 to 7 years of age. Among monozygotic pairs, the rate of tetrachoric correlation between co-twins was almost identical in males (0.73, SE 0.08) and females (0.74, SE 0.06), but among the dizygotic pairs the correlation was clearly higher in males (0.53, SE 0.12) than in females (0.20, SE 0.12). The value in the unlike-sexed dizygotic twins (0.25, SE 0.05) was intermediate to that of the like-sexed male and female dizygotic pairs. The relative contribution of genes and environment to variability in the predisposition to develop otitis media was estimated by means of structural equation modeling. Variation in liability to ear infections was mainly explained by additive genetic and dominance factors in females, for whom heritability was estimated at 74%. The remaining 26% of the variation in liability was explained by individual environmental factors. In males, 45% of the variation could be accounted for by genetic factors, 29% by common familial environment, and the remaining 26% by individual environmental effects.

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“…In the meta-analysis of Uhari et al [8], positive history of acute otitis media (AOM) in any other member of the family, increased the risk for AOM in a child by 2.63 times (CI 1.86-3.72). A marker of genetic inheritance, the HLA-A2 antigen, was found more frequently and the HLA-A3 less frequently in children with RAOM than in healthy children [32,33].…”

Section: Genetic Susceptibilitymentioning

confidence: 99%