HLA expression in choroidal melanomas: Correlation with clinicopathological features

Krishnakumar, Subramanian; Abhyankar, Dhiraj; Lakshmi, Sundaram Amirtha; Pushparaj, Vaijayanthi; Shanmugam, Mahesh Palanivelu; Biswas, Jyotirmay

doi:10.1080/02713680490503741

Cited by 11 publications

(5 citation statements)

References 12 publications

(12 reference statements)

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“…AP-1, a dimeric complex consisting of proteins encoded by the Jun and Fos gene families, is a transcription factor induced by a variety of signals, including those eliciting proliferation, differentiation, and programmed cell death (apoptosis). 18 In another dimension of the current study, it is of interest to know whether the differential expression of these proteins (IGF-1R, c-Fos, and c-Jun) would possibly classify uveal melanomas into two groups as shown earlier 19 (class I melanomas with favorable outcomes had decreased to absent human leukocyte antigen and beta 2 microglobulin, and class II melanomas with liver metastasis had strong expression of HLA and β 2 m). Recently, consistent with our findings, the Harbour et al 20 group has classified uveal melanomas into two groups, class 1 (low grade), and class 2 (high grade), based on the gene expression profile, which could strongly predict metastatic death in uveal melanoma patients.…”

Section: Introductionmentioning

confidence: 93%

Expression of Insulin-Like Growth Factor Receptor (IGF-1R), c-Fos, and c-Jun in Uveal Melanoma: An Immunohistochemical Study

Kandalam

Pushparaj

Biswas

et al. 2006

Current Eye Research

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The immunoreactivity of insulin-like growth factor receptor type 1 (IGF-1R), c-Fos, and c-Jun by immunohistochemistry was studied in three groups of uveal melanomas and was correlated clinicopathologically. Immunoanalysis was correlated with cell types, largest tumor diameter, tumor-infiltrating lymphocytes, mitosis, nuclear grade, and extrascleral extension/liver metastasis. In group C (n = 6), tumors with liver metastasis showed higher expressions of IGF-1R (p = 0.0001), c-Fos (p = 0.004), and c-Jun (p = 0.018) compared with the tumors with no extension/extrascleral extension without liver metastasis (groups A-45 and B-9). Further studies are required to elucidate the role of sequential upregulation of these proteins and the transcriptional activity of c-Fos and c-Jun in uveal melanomas with liver metastasis

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Section: Introductionmentioning

confidence: 93%

Expression of Insulin-Like Growth Factor Receptor (IGF-1R), c-Fos, and c-Jun in Uveal Melanoma: An Immunohistochemical Study

Kandalam

Pushparaj

Biswas

et al. 2006

Current Eye Research

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“…In addition to chromosome 3, aberrations in chromosomes 1 and 8 also have been studied in UM [28][29][30]. Abnormalities in the HLA class I, β2-m, and HLA class II antigens have been reported in UM by an Indian study group [31]. Another study from India [32] highlights the significance of antigen processing molecules in MHC class I expression in UM.…”

Section: Or • Disomy 3 and 8 • Monosomy 3 And 8q Gainmentioning

confidence: 99%

Uveal Melanoma in Asians: A Review

et al. 2021

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Despite limited data, some differences in the clinical profile can be observed in Asian population when compared with presentation of uveal melanoma (UM) in white population. The incidence of UM is higher in Whites than in Asians. For the purpose of comparison with Asian population, data from North America, Europe, and Australia were considered as that of “white” population. The annual incidence of UM has been reported to be 5–6 cases/million in whites. The incidence in different parts of Asia is estimated at 0.2–0.6 per million. The age of presentation is around 40–55 years in Asians, which is younger when compared to that of whites (mean age of 58 years). At presentation, mean basal diameter of tumors in Asians is greater compared to whites but overall, medium-size tumors are most common. Clinical presentation is straightforward in majority of cases with retinal detachment, acute glaucoma, uveitis, cataract, or vitreous hemorrhage as common symptoms. Epithelioid cell-type variant carries the worst prognosis. Management options for choroidal melanoma include transpupillary thermotherapy, plaque radiotherapy, charged particle irradiation, local resection, enucleation, or orbital exenteration. Most commonly used modalities are enucleation and plaque radiotherapy.

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“…The histopathologic features predicting prognosis of uveal melanoma include tumor cell type, mitotic activity, mean diameter of ten largest nucleoli, microvascular density (MVD), extravascular matrix patterns, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, insulin-like growth factor-1 receptor (IGF-1R), and human leukocyte antigen (HLA) Class I expression. [ 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 ]…”

Section: Histopathological Featuresmentioning

confidence: 99%

“…[ 109 110 111 ] However, some studies have found no association between HLA expression and melanoma-related mortality. [ 112 ]…”

Section: Histopathological Featuresmentioning

confidence: 99%

Uveal melanoma: Estimating prognosis

Kaliki

Shields

2015

Indian J Ophthalmol

235

248

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Uveal melanoma is the most common primary malignant tumor of the eye in adults, predominantly found in Caucasians. Local tumor control of uveal melanoma is excellent, yet this malignancy is associated with relatively high mortality secondary to metastasis. Various clinical, histopathological, cytogenetic features and gene expression features help in estimating the prognosis of uveal melanoma. The clinical features associated with poor prognosis in patients with uveal melanoma include older age at presentation, male gender, larger tumor basal diameter and thickness, ciliary body location, diffuse tumor configuration, association with ocular/oculodermal melanocytosis, extraocular tumor extension, and advanced tumor staging by American Joint Committee on Cancer classification. Histopathological features suggestive of poor prognosis include epithelioid cell type, high mitotic activity, higher values of mean diameter of ten largest nucleoli, higher microvascular density, extravascular matrix patterns, tumor-infiltrating lymphocytes, tumor-infiltrating macrophages, higher expression of insulin-like growth factor-1 receptor, and higher expression of human leukocyte antigen Class I and II. Monosomy 3, 1p loss, 6q loss, and 8q and those classified as Class II by gene expression are predictive of poor prognosis of uveal melanoma. In this review, we discuss the prognostic factors of uveal melanoma. A database search was performed on PubMed, using the terms “uvea,” “iris,” “ciliary body,” “choroid,” “melanoma,” “uveal melanoma” and “prognosis,” “metastasis,” “genetic testing,” “gene expression profiling.” Relevant English language articles were extracted, reviewed, and referenced appropriately.

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HLA expression in choroidal melanomas: Correlation with clinicopathological features

Cited by 11 publications

References 12 publications

Expression of Insulin-Like Growth Factor Receptor (IGF-1R), c-Fos, and c-Jun in Uveal Melanoma: An Immunohistochemical Study

Expression of Insulin-Like Growth Factor Receptor (IGF-1R), c-Fos, and c-Jun in Uveal Melanoma: An Immunohistochemical Study

Uveal Melanoma in Asians: A Review

Uveal melanoma: Estimating prognosis

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