HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease

Hosseini, Ehteramolsadat; Minagar, Arefeh; Ghasemzadeh, Mehran; Arabkhazaeli, Ali; Ghasemzadeh, Alireza

doi:10.1016/j.humimm.2023.02.002

Cited by 1 publication

(1 citation statement)

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“…In fact, while viral infection caused CD94/NKG2A overexpression, the virus-induced reduction of HLA-Ia expression produced a minor HLA-Ia leader peptide/HLA-E complex with reduced interaction with the CD94/NKG2A receptor, resulting in virus-infected cells being able to be eliminated by CD8+ and NK cells. Moreover, in this context and as shown in susceptibility to COVID-19 infection, because HLA-E*01:01 allele is less efficient at leading HLA class Ia leader peptide than the HLA-E*01:03 allele, HLA-E*01:01 usually presents better virus-derived peptides than the HLA-E*01:03, thus affecting target cell recognition and cytolysis of virus-infected cells by CD8+ T-cells [ 97 ]. Consistent with these observations, in a study of HBV, an expanded population of NK-like CD8+ T-cells characterized by a HLA-E/CD94/NKG2C interaction was found in hepatic sinusoids, leading to activation of NK-like cells independent of TCR stimulation [ 98 ].…”

Section: Non-classical Hla Class I Molecules (Hla-ib)mentioning

confidence: 99%

Non-Classical HLA Class 1b and Hepatocellular Carcinoma

Tornesello

Racanelli

et al. 2023

Biomedicines

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A number of studies are underway to gain a better understanding of the role of immunity in the pathogenesis of hepatocellular carcinoma and to identify subgroups of individuals who may benefit the most from systemic therapy according to the etiology of their tumor. Human leukocyte antigens play a key role in antigen presentation to T cells. This is fundamental to the host’s defense against pathogens and tumor cells. In addition, HLA-specific interactions with innate lymphoid cell receptors, such those present on natural killer cells and innate lymphoid cell type 2, have been shown to be important activators of immune function in the context of several liver diseases. More recent studies have highlighted the key role of members of the non-classical HLA-Ib and the transcript adjacent to the HLA-F locus, FAT10, in hepatocarcinoma. The present review analyzes the major contribution of these molecules to hepatic viral infection and hepatocellular prognosis. Particular attention has been paid to the association of natural killer and Vδ2 T-cell activation, mediated by specific HLA class Ib molecules, with risk assessment and novel treatment strategies to improve immunotherapy in HCC.

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Section: Non-classical Hla Class I Molecules (Hla-ib)mentioning

confidence: 99%