Hla-Dw3 Associated With Cœliac Disease

Keuning, J.J.; Peña, Amado Salvador; Hooff, J. P. van; Leeuwen, A. van; Rood, Jon J. van

doi:10.1016/s0140-6736(76)90294-4

Cited by 208 publications

(71 citation statements)

References 7 publications

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“…Four of four HLA-B8 positive and three of four B8 negative patients were DRW3 positive. Thus, in this patient group, DRW3 has the same prevalence in B8 positive and B8 negative patients, as previously pointed out by Keunig et al (6).…”

Section: Hla Typessupporting

confidence: 88%

“…In view ofthe known association of GSE with certain histocompatibility antigens (HLA-B8, HLA-DW3), (3)(4)(5)(6), we determined in the present study whether the deleterious effect of gluten in vitro is restricted by the patient's histocompatibility type. Accordingly, we examined small intestinal tissue from patients with GSE who were positive or negative for HLA-B8 and determined the susceptibility of the tissue in vitro to the cytotoxic effect of gluten protein.…”

Section: Introductionmentioning

confidence: 99%

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Gluten-sensitive Enteropathy

Falchuk¹,

Nelson²,

Katz³

et al. 1980

J. Clin. Invest.

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A B S T R A C T We previously developed an in vitro organ culture system in which gluten exerts a toxic effect on intestinal mucosa of patients with active gluten-sensitive enteropathy. Gluten generally inhibits the epithelial cell maturation of intestinal biopsy specimens that otherwise occurs if the tissue is cultured for 24-48 h in a gluten-free medium. However, small intestinal mucosa from 15-20% of patients with proven gluten-sensitive enteropathy fails to manifest the expected gluten-induced damage in vitro. In the present study, we explored the relation between in vitro gluteninduced intestinal damage and the presence of HLA-B8.We determined whether the patients' histocompatibility type (HLA-B8 positive or negative) influenced the ability of gluten protein to inhibit epithelial cell maturation of cultured intestinal biopsy specimens from patients with gluten-sensitive enteropathy.Intestinal biopsies from 21 of 24 patients with gluten-sensitive enteropathy and HLA-B8 showed gluteninduced dacmage in vitro. On the other hand, intestinal biopsies from only 4 of 16 patients with gluten-sensitive enteropathy I)ut without HLA-B8 showed gluteninduced daimage in vitro. The difference in the effect of gluten in vitro between these two groups was statistically significant (P < 0.01). The data show a dichotomy between gluten-induced tissue damage in vivo and in vitro in HLA-B8 negative patients, suggesting that Presented in part at

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Section: Hla Typessupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Gluten-sensitive Enteropathy

Falchuk¹,

Nelson²,

Katz³

et al. 1980

J. Clin. Invest.

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“…It is certainly not consistent with HLA-A29 being primary because it has the highest relative risk on the haplotype HLA-A29, B44, DR7, FC3 1. The fact that the majority of patient [HLA-B8, DR3, SCO ] do not carry HLA-A1 accounts mainly for the lower relative risk ofHLA-A1 compared with that ofHLA-B8 or DR3 observed in our study. In addition, there certainly is some population heterogeneity of allele frequencies in published studies, as judged from HLA studies of Caucasian patients in different regions (1)(2)(3)(4). Our HLA-A 1 relative risk of 1.7 is somewhat lower than that reported in a U.S. population at 3.64 (35) …”

Section: Methodscontrasting

confidence: 49%

“…Caucasian patients with gluten-sensitive enteropathy have increased frequencies of HLA-A 1, B8, Dw3/DR3, and Dw7/ DR7 and a decreased frequency ofHLA-B7 compared with normal controls (1)(2)(3)(4). Because the relative risk ofHLA-A I is lower than that of HLA-B8, the latter has been considered primary.…”

Section: Introductionmentioning

confidence: 99%

Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy.

Alper¹,

Fleischnick²,

Awdeh³

et al. 1987

J. Clin. Invest.

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We have studied major histocompatibility complex markers in randomly ascertained Caucasian patients with gluten-sensitive enteropathy and their families. The frequencies of extended haplotypes, defined as haplotypes of specific HLA-B, DR, BF, C2, C4A, and C4B allelic combinations, occurring more frequently than expected, were compared on patient chromosomes, on normal chromosomes from the study families, and on chromosomes from normal families. Over half of patient chromosomes consisted almost entirely of two extended haplotypes [HLA-B8, DR3, SCO1j and [HLA-B44, DR7, FC311 which, with nonextended HLA-DR7, accounted for the previously observed HLA markers of this disease: HLA-B8, DR3, and DR7. There was no increase in HLA-DR3 on nonextended haplotypes or in other extended haplotypes with HLA-DR3 or DR7. The distribution of homozygotes and heterozygotes for HLA-DR3 and DR7 was consistent with recessive inheritance of the major histocompatibility complex-linked susceptibility gene for gluten-sensitive enteropathy. On the other hand, by odds ratio analysis and from the sum of DR3 and DR7 homozygotes compared with DR3/ DR7 heterozygotes, there was an increase in heterozygotes and a decrease in homozygotes suggesting the presence of modifying phenomena.

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“…These conditions include SS (18,19,24), Graves' disease (25), juvenile onset diabetes mellitus (26), Addison's disease (26), Celiac disease (27), dermatitis herpetiformis (28), chronic active hepatitis of the juvenile type (29), idiopathic membranous nephropathy (30), and myasthenia gravis (31). One of the unifying features in all of these conditions could be a state of heightened immune responsiveness to either self or foreign antigenic stimulation.…”

Section: Discussionmentioning

confidence: 99%

Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus.

Šťastný²,

1981

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A B S T R A C T We have identified a clinically distinct subset of lupus erythematosus patients marked by the preseinee of' a histologically proven, noniscarring variety of cutaineous LE (subacute cutaneous LE) in which there is a very high frequency of the human leukocyte antigens (HLA) B8 and DR3. Differences in the configuration of their skin lesions allowed a separation of the patients into two clinical subgroups; annular and papulos(luamiious. HLA-B8 was increased in the annular subgroup (81%, corrected P (Pc) < 0.007) and combined group (65%, Pc < 0.004). HLA-DR3 was present in all 11 of the annular patients (100%, Pc < 0.00008). In addition, HLA-DR3 was present in increased frequencies in the papulosquamous subgroup (60%, Pc < 0.04) and combined group (77%, Pc < 0.00008). Thus, HLA-DR3 positive individuals have a relative risk of 10.8 for developing subacute cutaneous LE of either type and an even greater relative risk (67.1) for the annular variety. The HLA phenotype Al, B8, DR3 was also found more commonly in the annular (73%, P < 0.00008) and combiined patient groups (46%, P < 0.004). These HLA associations, which are stronger than ever before reported for any form of LE, did not result from the concurrent presence of subclinical Sjdgren's svndrome. Thus, subacute cutaneous LE can now be added to the growing list of HLA-B8, DR3-associated diseases that have autoimmune features.

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Hla-Dw3 Associated With Cœliac Disease

Cited by 208 publications

References 7 publications

Gluten-sensitive Enteropathy

Gluten-sensitive Enteropathy

Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy.

Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus.

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