Hla-Drw4 and Prognosis in Rheumatoid Arthritis

Roitt, Ivan M.; Corbett, Mary; Festenstein, H.; Jaraquemada, Dolores; Papasteriadis, C.; Hay, Frank C.; Nineham, L J

doi:10.1016/s0140-6736(78)90280-5

Cited by 67 publications

(14 citation statements)

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“…11,12 Our study also showed that RA prevalence is more common in adult females (0.25%) in comparison to adult males (0.18%), where the literature survey showed a prevalence varying between 0.5%-3.8% in women and from 0.15%-1.37% in men, with peak incidence in the fourth decade of life. Of the 13 patients with RA in our study, only two showed radiological evidence of erosive changes (15%).…”

Section: Discussionsupporting

confidence: 72%

The Prevalence of Rheumatoid Arthritis in the Qassim Region of Saudi Arabia

et al. 1998

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Background: Although rheumatoid arthritis (RA) of varying degrees of severity has been seen in our clinics, there is no statistical evidence of the magnitude of the problem in Saudi nationals. We conducted this study to determine the prevalence of RA in the Al Qassim Region of Saudi Arabia. Patients and Methods: Five thousand eight hundred and ninety-one Saudi adults, aged 16 years and over, were studied in a house-to-house survey in the Al Qassim Region. Results: Of the 5891 adults studied, 13 cases of RA were identified, using the criteria set for the diagnosis of RA by the American College of Rheumatology. Thirty-five percent of our patients showed positive rheumatoid factor. Conclusion:. The prevalence of RA in A1 Qassim was estimated at 2.2 per thousand people. It was also noted that the prevalence of the disease increased with age, and that it was more common in females. Rheumatoid arthritis (RA) is a common chronic inflammatory disease in developed countries. The prevalence of RA varies from country to country, from 0.7% 1 to 3%, 2 with an average of 1% in the adult population. 3,4 In the Gulf region, two studies estimated the prevalence of RA to be 1% in the Iraqi population, 5 and 0.36% in the Omani population. 6It is important to know the magnitude of the problem in Saudi Arabia, because the disease has been shown to put an enormous economic burden on the health services in particular, and on the society in general. The disease has been described as the most common inflammatory arthritis in a hospital-based population study in Saudi Arabia, and appears to be less severe than those encountered in developed countries, 7 but the magnitude of the problem in the general population is not fully known. Materials and MethodsBecause of the logistic and practical problems in population surveys for RA, which require detailed clinical examinations, personal histories and radiological and serological investigations of the subjects involved, the study was limited to the Al Qassim region in the Central part of Saudi Arabia. Based on the 1992 census figures, Qassim region has a population of 660,000, with a national growth rate of 5%, as estimated by the Ministry of Finance.We divided the region into three strata, according to the population density, as follows: large (>20,000 population), medium (5,000-20,000 population), and small (<5,000 population). Random samples were selected from each of the two large and medium-sized populations, while the third stratum of five villages was selected with probability proportionate to their size. Each village was treated as a cluster, and the number of households in each cluster or village was noted.The work was divided into three phases. During phase 1, a general practitioner and two nurses administered personal interviews to all inhabitants of the selected households. The main purpose of this was to identify individuals with symptoms of RA. In phase 2, trained nurses and paramedics administered a detailed questionnaire to all individuals identified in phase 1, with symptoms su...

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Section: Discussionsupporting

confidence: 72%

The Prevalence of Rheumatoid Arthritis in the Qassim Region of Saudi Arabia

et al. 1998

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“…The freqiuenicy of HLADw4 is especially increasedl in Caucasians who have severe, seropositive Ra which is relatively refractory to treatment (13,34,35). For example, DRw4 was found in 60% of' patients who re(uired gold, penicillamine, or steroi(ds to conitrol disease activity whereas only 20% of those ade(quately treated with aspirin had DRw4 (35).…”

Section: Resultsmentioning

confidence: 99%

Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis.

Rossen¹,

Brewer²,

Sharp³

et al. 1980

J. Clin. Invest.

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“…Studies concerning the relationship between DR antigens and disease severity in RA are limited (10)(11)(12)(33)(34)(35)(36). Interpretation of such studies is complica:ed by the fact that different parameters of disease severity (e.g., rate of progression, medication, functional capacity, etc.)…”

Section: Discussionmentioning

confidence: 99%

Seronegative rheumatoid arthritis.

Alarcón

Koopman

Acton

et al. 1982

Arthritis & Rheumatism

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Measurement of serum rheumatoid factor (RF)by conventional methods in patients with rheumatoid arthritis (RA) has repeatedly identified a subpopulation of patients without detectable RF. Previous investigators have consistently confirmed the association of HLA-DR4 with seropositive RA, but studies of seronegative RA have been Limited and contradictory. We studied 140 randomly selected patients from Alabama, all of whom had either classic or definite RA, and we were able to obtain complete HLA typing for 110 of these individuals. Eighty were consistently seropositive (on at least 2 separate occasions) and 30 were consistently seronegative (on at least 3 separate determinations). There was no statistically significant difference between the seronegative RA patients and 123 control subjects in the distribution of DR antigens. In seropositive RA, there was a significant increase in DR4 (PP>O.OOl; relative risk = 0.33).

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Hla-Drw4 and Prognosis in Rheumatoid Arthritis

Cited by 67 publications

References 0 publications

The Prevalence of Rheumatoid Arthritis in the Qassim Region of Saudi Arabia

The Prevalence of Rheumatoid Arthritis in the Qassim Region of Saudi Arabia

Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis.

Seronegative rheumatoid arthritis.

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