HLA‐DRB1 genotyping in patients with juvenile idiopathic arthritis in Taiwan

Abstract

The object of this study was to investigate whether there is an association between HLA-DRB1 alleles and the development of juvenile idiopathic arthritis (JIA) in Taiwan. HLA-DRB1 alleles were studied in 60 patients with JIA and 200 healthy controls using polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSO). The frequency of HLA-DRB1*0405 in patients with JIA was found to be significantly higher than that in healthy controls [odds ratio (OR) 2.64, 95% confidence interval (CI) 1.01-6.91]. The DRB1*0405 allele was significantly associated with the development of both polyarthritis (OR 4.30, 95% CI 1.34-13.80) and oligoarthritis (OR 3.27, 95% CI 1.01-10.58). The frequency of HLA-DRB1*1502 was higher in Taiwanese JIA patients with systemic arthritis than in controls (OR 18.09, 95% CI 2.25-145.73). We conclude that, in Taiwan, HLA-DRB1*0405 is associated with the development of polyarthritis and oligoarthritis in children, and HLA-DRB1*1502 is associated with the development of systemic arthritis.

Juvenile idiopathic arthritis profile in Turkish children

“…When the results of other studies from western countries were taken into consideration, we believe that the difference in immunogenetic background of ethnic groups may account for the differences in disease expression among the present study population. Our opinion has been supported by a number of studies 35–38 . It has been reported that JIA was primarily associated with HLA DRB1*08 and * 11, DQA1*0103, * 04 and *05 , and DQB1*04 alleles overall in Caucasian patients.…”

Proteomic Analysis of Plasma to Reveal the Impact of Short-Term Etanercept Therapy in Pediatric Patients with Enthesitis-Related Arthritis: A Case Report

“…Incidence varies on a geographical basis per 1000 children, from 0.04 in Taiwan, 0.07 in Poland, 0.7 in USA, and 1.0 in UK to 4.0 in Australia [1,2]. The International League of Associations for Rheumatology (ILAR) provides the current international diagnostic standard for identifying seven clinically homogeneous subtypes of JIA [1,3].…”

Association of HLA-A*02:06 and HLA-DRB1*04:05 with clinical subtypes of juvenile idiopathic arthritis

“…20 Although there is debate about whether rheumatoid arthritis and polyarticular JIA could be similar clinical conditions, 21 HLA-DRB1*04:05 may contribute to the pathogenesis of chronic arthritis at different ages and in different ethnic groups. Further studies are required to determine the molecular mechanisms by which HLA-DRB1*04:05 contributes to pathogenesis.…”