HLA‐DRB1, ‐DQB1 alleles in head and neck carcinoma patients

Koskinen, Walter J.; Partanen, Jukka; Vaheri, Antti; Aaltonen, Leena‐Maija

doi:10.1111/j.1399-0039.2006.00558.x

Cited by 12 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, HLA-DRB1*04 was found to be associated with fewer relapsing cancers, suggesting a severity moderation effect associated with these alleles. 46 Future researchers may be able to piece together the mechanisms involved in these complex outcomes.…”

Section: Hla Polymorphismsmentioning

confidence: 99%

The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors

et al. 2007

View full text Add to dashboard Cite

Human papillomaviruses (HPVs), with over 100 genotypes, are a very complex group of human pathogenic viruses. In most cases, HPV infection results in benign epithelial proliferations (verrucae). However, oncogenic types of HPV may induce malignant transformation in the presence of cofactors. For example, over 99% of all cervical cancers and a majority of vulval, vaginal, anal and penile cancers are the result of oncogenic HPV types. Such HPV types have been increasingly linked to other epithelial cancers involving the skin, larynx and oesophagus. Although viral infection is necessary for neoplastic transformation, evidence suggests that host and environmental cofactors are also required. Research investigating HPV oncogenesis is complex and quite extensive. The inability to produce mature HPV virions in animal models has been a major limitation in fully elucidating the oncogenic potential and role of associated cofactors in promoting malignant transformation in HPV-infected cells. We have reviewed the literature and provide a brief account of the current understanding of HPV oncogenesis, emphasizing the role of genetic susceptibility, immune response, and environmental and infectious cofactors.

show abstract

Section: Hla Polymorphismsmentioning

confidence: 99%

The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This is demonstrated by the studies of genetic and structural changes that lead to disturbances in expression of MHC class I molecules and MHC class II antigens on tumor cells and indicate the relationship of these aberrations with a reduced activity of effector cells and the phenomenon of 'tumor escape' against the defense mechanisms of cellular immune response [35][36][37][38][42][43][44][45].…”

Section: Cd45romentioning

confidence: 99%

“…Most of the articles concerned the analysis of the activity of the marker on cancer cells isolated from tumor or cell lines and assessing correlation of coexpressed HLA/DR + on both tumor cells and immune cells, mainly on tumor infiltrating lymphocytes (TIL) [16,[35][36][37][38][39]. Evaluation of HLA/DR + on these cell types was not studied in this group of squamous cell carcinoma of the larynx, but the results presented in the literature clearly indicate the interactions and the effect of tumor cells on the ) and the ability to infiltrate the tumor front in squamous cell carcinoma of the larynx.…”

Section: Cd45romentioning

confidence: 99%

The role of tumor cells in the modification of T lymphocytes activity — the expression of the early CD69+, CD71+ and the late CD25+, CD26+, HLA/DR+ activation markers on T CD4+ and CD8+ cells in squamous cell laryngeal carcinoma. Part I

Starska¹,

Głowacka²,

Kulig³

et al. 2012

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Apart from the antigen expression pattern, HLA‐linked genetic components are supposed to play a role in cancerogenesis as certain alleles or polymorphisms of genes located in the MHC‐region have been shown to contribute to cancer susceptibility 14–17…”

mentioning

confidence: 99%

Genetic alterations of HLA‐class II in ovarian cancer

Kübler

Arndt

Wardelmann

et al. 2008

Intl Journal of Cancer

View full text Add to dashboard Cite

The immune system controls tumor formation through identification and elimination of cellular alterations. Consequently, cancer development in immune competent hosts depends on strategies to evade the immune system. Modulation of tumor antigen-specific immune responses by aberrant expression of HLA-class I and II molecules is well documented in a variety of carcinomas including ovarian cancer. To date, little data are available about molecular mechanisms responsible for altered HLA-class II phenotypes in tumors. In our sample of 10 Caucasian patients with ovarian carcinoma, a semiquantitative analysis was performed for HLA-class II loci DRB1 and DQB1 in malignant and normal ovarian tissue. Gene amplifications were identified in 62.5% of analyzed alleles and deletions in 17.5%, demonstrating that genomic aberrations of 6p21.3 are common and that copy number gain is more frequent than loss. Moreover, amplifications are most pronounced in advanced-stage tumors. To evaluate genotype-phenotype relation, immunohistochemical analyses were performed and revealed de novo expression of HLA-class II in 30% of tumors with an inverse association between antigen level and HLA copy number. It remains to be elucidated whether the profound changes of the latter quantities are the result of the host's immunological selfdefense, indicate the presence of an oncogene located within the MHC-complex or merely reflect the increasing loss of differentiation of the tumor tissue.

show abstract

HLA‐DRB1, ‐DQB1 alleles in head and neck carcinoma patients

Cited by 12 publications

References 28 publications

The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors

The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors

Genetic alterations of HLA‐class II in ovarian cancer

Contact Info

Product

Resources

About