HLA DRB1 and DQB1 alleles and haplotypes influencing the progression of hepatitis C

Aikawa, Tatsuya; Kojima, M.; Ōnishi, Hiroshi; Tamura, Ryoji; Fukuda, Satoko; Suzuki, Takashi; Tsuda, Fumio; Okamoto, Hiroaki; Miyakawa, Yuzo; Mayumi, Makoto

doi:10.1002/(sici)1096-9071(199608)49:4<274::aid-jmv3>3.0.co;2-0

Cited by 53 publications

(41 citation statements)

References 21 publications

(16 reference statements)

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“…Two Japanese studies compared HCV carriers with normal liver function tests and normal histology with patients with elevated liver function tests and cirrhosis, respectively. 61,62 In both studies, DQB1*0401, DRB1*0405, and the two-locus haplotype consisting of these alleles were more frequent in those who developed chronic liver disease. However, because Kuzushita et al also typed class I alleles, they showed that subjects with the three-locus haplotype, HLA-B54-DQB1*0401-DRB1*0405, were 13 times as likely to have liver injury relative to those with the two-locus haplotype without B54.…”

Section: Hepatitis C Virusmentioning

confidence: 84%

Chronic viral hepatitis and the human genome

Thio¹,

Thomas²,

Carrington

2000

Hepatology

108

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Section: Hepatitis C Virusmentioning

confidence: 84%

Chronic viral hepatitis and the human genome

Thio¹,

Thomas²,

Carrington

2000

Hepatology

108

View full text Add to dashboard Cite

“…In infants born to infected mothers HLA DRB1*1104 is associated with seroreversion and DRB1*1101 with viral persistence [79] for HCV infection. In Japanese and the DRB1*0901-DQB1*0303 haplotype is related to protection from cirrhosis in hepatitis C [70] and HLA B44-DRB1*1302-DQB1*0604 and DRB1*1302-DRB1*0604 with asymptomatic carrier phenotype [68] . HLA class Ⅲ allele associations: HLA class Ⅲ and cytokine genes have been reported in influencing HCV infection outcome.…”

Section: Viral Persistence and Viral Clearancementioning

confidence: 99%

“…Increased expression of inhibitory receptor CD94/NKG2A on NK cells was found in chronic hepatitis C patients and is suggested to contribute to immune resistance towards HCV infection and HCV mediated cellular transformation via modulating dendritic cell function and cytokine secretion [66,67] . HLA class Ⅱ allele associations: HLA DRB1*0405 and DQB1*0401/0402 alleles are associated with viral persistence and chronic HCV infection in Japanese [68][69][70] . Also, DRB1*0405-DQB1*0401/0402 haplotype [59] and HLA B54-DRB1*0405-DQB1*0401 haplotype are associated with HCV induced liver injury [68] .…”

Section: Viral Persistence and Viral Clearancementioning

confidence: 99%

“…In European and North American Caucasians HLA DRB1*0301 is strongly associated with AIHⅠ [97] , and in most European population DRB1*0301 is associated with HCV persistence (Table 6). HLA DRB1*0405 is a susceptible allele for AIH Ⅰas well as HCV viral persistence in Japanese [68,70,97] . In Germans DRB1*07 is a risk factor for AIH Ⅱ, and is also found associated with HCV viral persistence [94,97] .…”

Section: Extra-hepatic Manifestations Of Hepatitis B and Hepatitis C mentioning

confidence: 99%

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A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Singh

Kaul

et al. 2007

WJG

202

175

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Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC).Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment. Extensive literature search was conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLA DR13 is consistently associated with HBV clearance globally. HLADRB1*11/*12 alleles and DQB1*0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class Ⅰmolecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific therapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations.

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“…[11][12][13][14] In contrast, several studies have suggested that specific HLA class II alleles may influence outcome parameters in chronic HCV infection such as disease susceptibility, viral clearance, or disease severity. [15][16][17][18][19][20][21] However, many of these studies were small and reported inconsistent findings. Despite the propensity of HCV to present a diverse range of epitopes for T cell recognition, heterozygous advantage has not been addressed or demonstrated in these studies.…”

mentioning

confidence: 99%

HLA class I allelic diversity and progression of fibrosis in patients with chronic hepatitis C

et al. 2006

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Patients infected with HIV-1 who are heterozygous at HLA class I loci present greater variety of antigenic peptides to CD8 ؉ cytotoxic T lymphocytes, slowing progression to AIDS. A similar broad immune response in chronic hepatitis C (CHC) infection could result in greater hepatic injury. Although specific HLA class II alleles may influence outcome in CHC patients, the role of HLA class I heterogeneity is generally less clearly defined. Our aims were to determine whether HLA class I allelic diversity is associated with disease severity and progression of fibrosis in CHC. The study population consisted of 670 adults with CHC, including 155 with advanced cirrhosis, and 237 non-HCV-infected controls. Serological testing for HLA class I antigens was performed via microlymphocytotoxicity assay. Peptide expression was defined as heterozygous (i.e., a different allele at each locus) or homozygous. The majority of these patients develop chronic infection, which is characterized by varying degrees of inflammation and hepatic fibrosis. A proportion of patients (Ͻ20%) will develop progressive liver damage with subsequent cirrhosis, end-stage liver disease, and hepatocellular carcinoma over 20 to 40 years. 3 The immunopathogenic mechanisms responsible for viral persistence and varying degrees of hepatic injury in chronic hepatitis C (CHC) are poorly understood. Cellular immune responses probably play an important role in this regard. CD4 ϩ T helper cells recognize HCV-derived peptides in the HLA class II binding groove of antigenpresenting cells such as dendritic cells, macrophages, and B cells. CD8 ϩ cytotoxic T cell lymphocytes (CTL) recognize intracellularly processed HCV proteins presented on HLA class I molecules on virus-infected cells. The HLA class I and II loci contain a highly polymorphic set of genes that appear to have evolved over time through selection pressures, thus allowing the host to resist a variety of pathogens. 4 In comparison with homozygous individuals, persons with overdominant selection or heterozygote advantage at HLA loci may be able to present a greater variety of antigenic peptides to T cells, thus result-

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HLA DRB1 and DQB1 alleles and haplotypes influencing the progression of hepatitis C

Cited by 53 publications

References 21 publications

Chronic viral hepatitis and the human genome

Chronic viral hepatitis and the human genome

A comparative review of HLA associations with hepatitis B and C viral infections across global populations

HLA class I allelic diversity and progression of fibrosis in patients with chronic hepatitis C

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