HLA‐DRB1 allele frequency and immunological response in obstructive sleep apnea syndrome in Turkish population

Abstract

These results suggest that the DRB1*03 allele may play a predisposing role in OSAS disease and that the DRB1*08 allele may be related to the severity of the disease. In addition, the decrease in CD4, CD8, NK and HLA DR increase in this disease suggests that the disease causes impairment of the immunological system and may be associated with autoimmunity.

Relationship between obstructive sleep apnea and human leukocyte antigen variants

“…Such a result can be considered unique to Turkey since the HLA locus is a polymorphic gene region with important ethnic differences. In other studies conducted in our country (26,27), such a relation was not found. For the same region, the p value of the HLA-B * 44: 03 allele was found to be 0.054 and was considered as insignificant.…”

“…To date, it seems like there have been two studies which investigate the possible relationship between OSA and HLA genes in Turkey.The first of these was published in the year of 2003 and the frequency of the HLA-DRB1 * 15 allele was shown to be higher in patient group (26).In another study conducted in 2018, the frequency of HLA-DRB1 alleles was evaluated in OSA patients and it was reported that the DRB1 * 03 allele had a predisposing role and the HLA-DRB1 * 08 allele was associated with the severity of OSA (27).The studies conducted in the world and our country and the results of our study are summarized in Table 4. Amongst those studies, a HLA region analysis as detailed as ours was only performed by Yoshizawa, (20,25,26).…”

“…This allele which is frequently observed in the patient group, and was thought to be predisposing to the disease. Tepebaşı and Silva reported that the HLA-DRB1 * 03 allele and the HLA-DRB1 * 09 allele were predisposing for OSA (22,27). There is no previous report of any kind of relation between DRB1*04:05 allele and OSA.…”

Analysis of urine differential proteins in patients with allergic rhinitis

“…Among the up-regulated proteins, the most differentially expressed protein was the HLA class II histocompatibility antigen, DRB1-10 beta chain (HLA-DRB1), a beta chain of an antigen-presenting major histocompatibility complex class II (MHCII) molecule. Together with the chain, they form a functional protein complex known as the HLA-DR antigen-binding heterodimer, which presents foreign peptides to the immune system to initiate an immunological response [ 27 , 28 ]. Regarding biomarker applications, Klimenta et al found that patients with HLA-DRB1 gene mutations had an increased risk of developing rheumatoid arthritis [ 29 ].…”