HLA-DRB1*09 Is Associated with Increased Incidence of Cytomegalovirus Infection and Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Du, Jiang; Liu, Jing; Gu, Jiangying; Zhu, Ping

doi:10.1016/j.bbmt.2007.09.003

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…2012 [ 42 ] China, Beijing ALL, CML, MDS, AA, NHL 60 (87%) 0.92 0.9 Allo-HCT Du et al . 2007 [ 128 ] Taiwan, Kaohsiung, Taipei AL, NHL 117 (91.8%) 0.95 0.93 Allo-HCT Liu et al . 2012 [ 43 ] Japan, Tokyo Childhood AL 184 (81%) 0.76 0.72 UCBT Tomonari et al .…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Janković

Knežević

Todorović

et al. 2022

Virol J

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Background Although cytomegalovirus (CMV) is not considered tumorigenic, there is evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental and clinical studies suggest its putative anti-tumour effect. We investigated the potential connection between chronic CMV infection in patients with B-lymphocyte (B-cell) malignancies in a retrospective single-center study and extracted relevant data on CMV prevalences and the incidences of B-cell cancers the world over. Methods In the clinical single-center study, prevalence of chronic CMV infection was compared between patients with B-cell leukemia/lymphoma and the healthy controls. Also, global data on CMV seroprevalences and the corresponding country-specific incidences of B- lineage neoplasms worldwide were investigated for potential correlations. Results Significantly higher CMV seropositivity was observed in control subjects than in patients with B-cell malignancies (p = 0.035). Moreover, an unexpected seroepidemiological evidence of highly significant inverse relationship between country-specific CMV prevalence and the annual incidence of B-cell neoplasms was noted across the populations worldwide (ρ = −0.625, p < 0.001). Conclusions We try to draw attention to an unreported interplay between CMV infection and B-cell lymphomagenesis in adults. A large-scale survey across > 70 countries disclosed a link between CMV and B-cell neoplasms. Our evidence hints at an antagonistic effect of chronic CMV infection against B-lymphoproliferation.

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Janković

Knežević

Todorović

et al. 2022

Virol J

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“…Although accumulated evidence from extensive recent research indicates a role for HLA allele matching and haplotype matching between recipients and donors in transplant outcomes [28][29][30][31], the association between a particular HLA allele or HLA haplotype and the occurrence of infection has been scarcely explored. Du et al [32] demonstrated using multivariable analysis that HLA-DRB1*09, grade II to IV acute GVHD, and CMV-seronegative donors were associated with an increased incidence of CMV infection and disease after allo-HSCT, although their sample size was relatively small. We could not replicate this association.…”

Section: Discussionmentioning

confidence: 99%

Impact of High-Frequency HLA Haplotypes on Clinical Cytomegalovirus Reactivation in Allogeneic Hematopoietic Stem Cell Transplantation

Kawase

Tanaka²,

Kojima³

et al. 2019

Biology of Blood and Marrow Transplantation

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Some studies support the hypothesis that HLA genes and haplotypes evolved by natural selection through their protective abilities against specific infectious pathogens. However, very little is known regarding the impact of high-frequency HLA haplotypes on the risk of relevant infectious diseases among a given ethnic group. We evaluated the impact of high-frequency HLA haplotypes on cytomegalovirus (CMV) reactivation and infection in allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a Japanese population as a model of infectious disease that has coexisted with humans. A total of 21,127 donor-patient pairs were analyzed. HLA-A-B-DRB1 haplotypes were estimated using the maximum probability algorithm. Seven haplotypes with >1% frequency were defined as high-frequency haplotypes (HfHPs). Homozygotes of HfHP and heterozygotes had significantly lower risk of CMV reactivation and infection (hazard ratio [HR] = 0.88, P = .009 and HR = 0.93, P = .003, respectively) than homozygotes of low-frequency HLA haplotypes (LfHPs). In subgroup analyses of a different donor source, these associations were statistically significant in unrelated donor transplants. Finally, CMV risk for homozygotes and heterozygotes of each HfHP was compared with that of homozygotes of LfHPs. The 2 most predominant HfHP groups (A*24:02-B*52:01-DRB1*15:02 group and A*24:02-B*07:02-DRB1*01:01 group) had a significantly lower risk of CMV reactivation and infection (HR = 0.86, P < .001 and HR = 0.91, P = .033, respectively). Our findings suggest that HfHPs may be protective against CMV reactivation and infection and that increased care regarding CMV reactivation and infection may be necessary for patients with LfHP after allo-HSCT.

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“…RA-associated HLA alleles ⇒ susceptibility to certain trivial infections ⇒ increased infection incidence and duration [ 155 , 156 , 157 , 158 , 159 , 160 , 161 ].…”

Section: Methodsmentioning

confidence: 99%

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

Arleevskaya

Takha

Petrov

et al. 2022

IJMS

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In this review, we explore systemization of knowledge about the triggering effects of non-genetic factors in pathogenic mechanisms that contribute to the development of rheumatoid arthritis (RA). Possible mechanisms involving environmental and individual factors in RA pathogenesis were analyzed, namely, infections, mental stress, sleep deprivation ecology, age, perinatal and gender factors, eating habits, obesity and smoking. The non-genetic factors modulate basic processes in the body with the impact of these factors being non-specific, but these common challenges may be decisive for advancement of the disease in the predisposed body at risk for RA. The provocation of this particular disease is associated with the presence of congenital loci minoris resistentia. The more frequent non-genetic factors form tangles of interdependent relationships and, thereby, several interdependent external factors hit one vulnerable basic process at once, either provoking or reinforcing each other.Understanding the specific mechanisms by which environmental and individual factors impact an individual under RA risk in the preclinical stages can contribute to early disease diagnosis and,if the factor is modifiable, might be useful for the prevention or delay of its development.

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HLA-DRB1*09 Is Associated with Increased Incidence of Cytomegalovirus Infection and Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Cited by 9 publications

References 20 publications

Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

Impact of High-Frequency HLA Haplotypes on Clinical Cytomegalovirus Reactivation in Allogeneic Hematopoietic Stem Cell Transplantation

Interplay of Environmental, Individual and Genetic Factors in Rheumatoid Arthritis Provocation

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