HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population

Abstract

The etiology of lichen planus (LP) is still unknown and previous studies have found an association between LP and HLA-DR1, DR2, DR3, DR9 and DR10 in different populations. The aim of this study was to analyze the distribution of the HLA-DRB1 alleles in Mexican Mestizo patients with LP. The aim of this study was to determine the gene frequency of HLA-DR locus in Mexican Mestizo patients with LP. We studied 20 patients with LP and 99 healthy Mexican Mestizo controls. HLA-DRB1 was performed by PCR-SSO reverse dot blot hybridization. High resolution HLA typing was performed by PCR-SSP. The HLA-DRB1*0101 allele was associated significantly in LP patients compared with healthy controls (pC = 0.0007, OR = 5.46, 95% CI = 1.86-16.06). HLA-DRB1*0101 is a marker for the development of LP in Mexican Mestizo population, yet another gene or HLA marker within MHC region may be the causatively associated gene.

Lichen Planopilaris is Associated with HLA DRB1*11 and DQB1*03 Alleles

“…Interestingly, in Jewish patients with oral erosive lichen planus, there was a significant association of the disease with HLA-DR2 and a decrease in DR4 frequency (16). HLA-DRB1*01: 01 was found to be associated with a genetic susceptibility for LP in the Mexican Mestizo population (6). To our knowledge, the present study is the first to examine the association of HLA and LPP.…”

“…The literature on the ethnic predilection of the disease is sparse; in the 3 largest case series from North American institutions, the majority of patients were Caucasian, commensurate with the percentage of Caucasians in the general population (2,29,30). The association between HLA antigens and LP has been studied extensively, but the findings differ by disease variants (7,(11)(12)(13)15) and by populations studied (6,8,9,16,17). For example, serological typing of HLA DR1 was positive in 80% of American patients with generalized cutaneous LP compared with 25% of healthy controls (21).…”

“…The aetiology of LP in general and LPP in particular is unknown, although an autoimmune origin is suspected. Despite extensive studies of the human leukocyte antigen (HLA) system in T-cell-mediated diseases (4), including LP (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), little is known about the possible role of the HLA system in LPP.…”

Linear lichen planus along the lines of Blaschko in three adult women

“…LLP is considered to be because of a cell-mediated immune reaction of unknown cause and one could speculate that this is because of immune recognition of a genetically distinct subclone. LP has been associated with specific HLA subtypes DRB1*0101, DR1, DR2, DR3, DR9, and DR10 in different populations (Luis-Montoya et al, 2007). Although no specific genetic tests were performed in our and other reported case series, we believe that LLP is a remarkable model to study the interaction between the environment and genotype.…”

Estudo da associação entre antígenos de histocompatibilidade leucocitária e penfigoide bolhoso em pacientes brasileiros

“…O sistema HLA é objeto de estudo para identificar os alelos envolvidos na patogênese de diversas doenças, tais como estomatite aftoide recorrente, líquen plano, pênfigo vulgar, penfigoides e seus subtipos [71][72][73] .…”