HLA-DR4-associated nonresponsiveness to mountain-cedar allergen

Reid, Michael; Nish, William A.; Whisman, Bonnie A.; Goetz, David W.; Hylander, Robert D.; Parker, William A.; Freeman, Theodore M.

doi:10.1016/0091-6749(92)90327-x

Cited by 52 publications

(28 citation statements)

References 20 publications

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“…Whereas, in IgEmediated asthma, a strong positive association with haplotype DR4 is found, in isocyanate-induced asthma the frequency of haplotype DR4 is low and does not differ from controls. This finding confirms recent observations, showing a significant decrease of haplotype DR4 frequency in subjects with sensitization to mountain cedar [98]. It is interesting to note, that in both cases, the causal agents are small molecular weight compounds (isocyanate or plicatic acid).…”

Section: Genetic Mechanismsupporting

confidence: 81%

Mechanisms and pathology of occupational asthma

Mapp

Saetta²,

Maestrelli³

et al. 1994

Eur Respir J

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M Me ec ch ha an ni is sm ms s a an nd d p pa at th ho ol lo og gy y o of f o oc cc cu up pa at ti io on na al l a as st th hm ma a More than one mechanism may be operative in occupational asthma. Among the mechanisms proposed, immunological mechanisms and airway inflammation play an important role. There is evidence to confirm that T-lymphocyte activation and local accumulation in the bronchial wall of activated eosinophils occurs in asthma of diverse aetiology, i.e. immunoglobulin E (IgE)-mediated, occupational and intrinsic.Neurogenic pathways should be further investigated as a potential mechanism of modulation and amplification of airway inflammation in occupational asthma.

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Section: Genetic Mechanismsupporting

confidence: 81%

Mechanisms and pathology of occupational asthma

Mapp

Saetta²,

Maestrelli³

et al. 1994

Eur Respir J

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“…Some vasculitides are also associated with such HLA alleles: giant cell arteritis is significantly associated with HLA-DRB1*04 (14). HLA-DRB1*04 and (to a lesser extent) HLA-DRB1*07 have been found to be associated with atopy (37,38), but these results were not corroborated in other investigations (39). Finally, an HLA profile strikingly similar to that observed in CSS (i.e., increased HLA-DRB4 and reduced HLA-DRB3 frequency) has been found in childhood acute lymphoblastic leukemia (40).…”

Section: Discussioncontrasting

confidence: 49%

HLA–DRB4 as a genetic risk factor for Churg‐Strauss syndrome

Vaglio

Martorana

Maggiore

et al. 2007

Arthritis & Rheumatism

169

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Objective. To explore the association between HLA alleles and Churg-Strauss syndrome (CSS), and to investigate the potential influence of HLA alleles on the clinical spectrum of the disease.Methods. Low-resolution genotyping of HLA-A, HLA-B, and HLA-DR loci and genotyping of TNFA ؊238A/G and TNFA ؊308A/G single-nucleotide polymorphisms were performed in 48 consecutive CSS patients and 350 healthy controls.Results.

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“…Many other possible positive [35, 36, 37, 38, 39] and negative [40, 41, 42] MHC associations with allergen reactivity have been described. The overall effect of the MHC on allergens seems to be a multiplicity of small effects, usually conferring a relative risk of less than 2 [43].…”

Section: Genes Influencing Specific Ige Responses To Particular Allementioning

confidence: 99%

Gene Identification in Asthma and Allergy

Moffatt¹,

Cookson²

1998

Int Arch Allergy Immunol

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Asthma and atopy are due to the interaction between genetic and environmental factors. The genetic basis of asthma and atopy is becoming more certain, with the promise of improvements in the diagnosis and treatment of these disorders. A combination of candidate gene and positional cloning studies has already identified several genes which influence allergic disease. These genes predispose in general to atopy, or influence the specific IgE response to individual allergens, or enhance inflammation independently of atopic mechanisms. In addition to these known factors, the chromosomal localisation of other putative genes is becoming clear.

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HLA-DR4-associated nonresponsiveness to mountain-cedar allergen

Cited by 52 publications

References 20 publications

Mechanisms and pathology of occupational asthma

Mechanisms and pathology of occupational asthma

HLA–DRB4 as a genetic risk factor for Churg‐Strauss syndrome

Gene Identification in Asthma and Allergy

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