HLA‐DR phenotypes and blood levels of T cell subsets

Caruso, Calogero; Lio, Domenico; Palmeri, Patrizia; Cillari, Enrìco

doi:10.1111/j.1399-0039.1984.tb02145.x

Cited by 12 publications

(1 citation statement)

References 9 publications

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“…This results in an autoimmune response with potentiation of tissue damage by organ-specific autoantibe dies. Alternatively, the presence of non-organ-specific autoantibodies in patients with autoimmune CAH may indicate a lack of effective immune suppression in subjects with B8, DR3 (Ambinder et al 1982); we note differences in T-cell subsets between subjects with B8, DR3 and other haloptypes (Caruso et al 1984) and the finding that lymphocytes from subjects with B8, DR3 respond differently to mitogens (Kallenberg et al 1988).…”

Section: Discussionmentioning

confidence: 73%

Lack of informative HLA restriction fragment length polymorphisms in autoimmune chronic active hepatitis

et al. 1989

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Autoimmune chronic active hepatitis (CAH) is strongly associated with HLA-B8, DR3. Accordingly, DNA was isolated from 10 HLA-B8, DR3 control subjects and 11 patients with autoimmune CAH and analyzed for informative restriction fragment length polymorphisms using HLA-DQ beta and DR beta probes, and six enzymes, Hinc II, Bgl II, Bam HI, Rsa I, Taq I and Msp I. None of the polymorphic fragments demonstrable was discriminatory for autoimmune CAH. A genetic polymorphism in the HLA-B8, DR3 region predisposing to autoimmune CAH may not have been detecting owing to an insufficient number of probes or enzymes used, or alternatively HLA-DR3 is predisposing by an effect on immune regulation or suppression.

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Section: Discussionmentioning

confidence: 73%