1996
DOI: 10.1016/s0748-7983(96)92940-6
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HLA-DR expression and lymphocytic infiltration in metastatic and non-metastatic papillary carcinoma of the thyroid

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Cited by 8 publications
(6 citation statements)
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“…In our study, we demonstrated that the abundance of CD 45 R0 positive lymphocytes was highest in anaplastic carcinomas, whereas follicular carcinomas had less infiltration than papillary cancers (Herrmann et al, 1994;Scholzen and Gerdes, 2000). Thus active specific memory cells are a major component of the TILs (Katsumoto et al, 1996;Ozaki et al, 1999), which may explain the concomitant increase of the CD 45 R0+ TILs and HLA DR expressing thyroid carcinoma cells (Catµlfamo, 1999;Feinmesser et al, 1996;Matsuoka et al, 1996).…”
Section: Discussionmentioning
confidence: 51%
“…In our study, we demonstrated that the abundance of CD 45 R0 positive lymphocytes was highest in anaplastic carcinomas, whereas follicular carcinomas had less infiltration than papillary cancers (Herrmann et al, 1994;Scholzen and Gerdes, 2000). Thus active specific memory cells are a major component of the TILs (Katsumoto et al, 1996;Ozaki et al, 1999), which may explain the concomitant increase of the CD 45 R0+ TILs and HLA DR expressing thyroid carcinoma cells (Catµlfamo, 1999;Feinmesser et al, 1996;Matsuoka et al, 1996).…”
Section: Discussionmentioning
confidence: 51%
“…We excluded additional 24 articles following full‐text screening step. Finally, 35 studies with a total of 73,339 DTC patients were included for final analysis [5–13, 15–22, 24, 25, 32–47] (Fig. 1).…”
Section: Resultsmentioning
confidence: 99%
“…However, there is a small proportion of cases with aggressive features at presentation, which develop early distant metastasis or distant relapse and are associated with adverse outcomes. Although DM is not a frequent event in DTCs [5][6][7][8][9], it was reported to have adverse impact on survival in DTC patients [9][10][11][12][13][14][15]. Therefore, it is crucial to identify this group of patients to better assess patient prognosis and tailor therapeutic decision.…”
Section: Introductionmentioning
confidence: 99%
“…The expression of HLA-DR antigens in DTC was investigated in detail, but its role in immune recognition and anti-tumor immunity was not clarified (Goldsmith et al, 1988;Feinmesser et al, 1996). Recently, it was suggested that HLA-DR expression in the absence of lymphocytic infiltration might be the marker of immune tolerance and indicated poor prognosis (Matsubayashi et al, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…In thyroid cancer patients with thyroiditis, a better survival rate was observed (Kashima et al, 1998). HLA-DR antigens are expressed on tumor cells and on peritumoral lymphocytes (Goldsmith et al, 1988;Feinmesser et al, 1996). The association of DTC with certain HLA-DR alleles was reported (Juhasz et al, 1989).…”
Section: Introductionmentioning
confidence: 99%