HLA-DR expression and lymphocytic infiltration in metastatic and non-metastatic papillary carcinoma of the thyroid

Feinmesser, Meora; Stern, Sidi; Mechlis-Frish, Sara; Lubin, Ernesto; Feinmesser, Raphael; Kristt, Donald A.

doi:10.1016/s0748-7983(96)92940-6

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…In our study, we demonstrated that the abundance of CD 45 R0 positive lymphocytes was highest in anaplastic carcinomas, whereas follicular carcinomas had less infiltration than papillary cancers (Herrmann et al, 1994;Scholzen and Gerdes, 2000). Thus active specific memory cells are a major component of the TILs (Katsumoto et al, 1996;Ozaki et al, 1999), which may explain the concomitant increase of the CD 45 R0+ TILs and HLA DR expressing thyroid carcinoma cells (Catµlfamo, 1999;Feinmesser et al, 1996;Matsuoka et al, 1996).…”

Section: Discussionmentioning

confidence: 51%

Differences in tumor cell proliferation, HLA DR expression and lymphocytic infiltration in various types of thyroid carcinoma

Lindhorst¹,

Pm²,

Bojunga³

et al. 2002

Exp Clin Endocrinol Diabetes

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The proliferative activity of various thyroid carcinoma forms (papillary, follicular, medullary, anaplastic) was investigated using two second generation antibodies against Ki-67 that can be used on paraffin-embedded sections. Poorly-differentiated carcinomas had a higher proliferation than well-differentiated forms. Papillary carcinoma stained significantly more often with either antibody than follicular carcinoma. A solid growth pattern correlated with high Ki-67 expression while an increase in follicular elements and a high amount of psammoma bodies coincided with lower proliferation.HLA class II expression and infiltrating lymphocytes are prerequisites for an immune defense against cancer. In this study, HLA DR was increased in poorly-differentiated carcinomas, especially in the anaplastic type. The increase in HLA DR was correlated with Ki-67 positivity. On tumor-infiltrating lymphocytes, HLA DR was well expressed in papillary carcinoma and relatively poorly expressed in follicular carcinoma, but there was no significant correlation with carcinoma type or morphological parameters. CD 45 R0, which might recognize memory cells, was found mostly in anaplastic and papillary carcinomas, and correlated well with HLA DR expression. These findings imply that an active but variable immune response is present in thyroid carcinoma.

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Section: Discussionmentioning

confidence: 51%

Differences in tumor cell proliferation, HLA DR expression and lymphocytic infiltration in various types of thyroid carcinoma

Lindhorst¹,

Pm²,

Bojunga³

et al. 2002

Exp Clin Endocrinol Diabetes

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“…We excluded additional 24 articles following full‐text screening step. Finally, 35 studies with a total of 73,339 DTC patients were included for final analysis [5–13, 15–22, 24, 25, 32–47] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…However, there is a small proportion of cases with aggressive features at presentation, which develop early distant metastasis or distant relapse and are associated with adverse outcomes. Although DM is not a frequent event in DTCs [5][6][7][8][9], it was reported to have adverse impact on survival in DTC patients [9][10][11][12][13][14][15]. Therefore, it is crucial to identify this group of patients to better assess patient prognosis and tailor therapeutic decision.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Risk Factors for Distant Metastasis in Differentiated Thyroid Carcinoma: A Meta‐analysis

et al. 2017

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“…The expression of HLA-DR antigens in DTC was investigated in detail, but its role in immune recognition and anti-tumor immunity was not clarified (Goldsmith et al, 1988;Feinmesser et al, 1996). Recently, it was suggested that HLA-DR expression in the absence of lymphocytic infiltration might be the marker of immune tolerance and indicated poor prognosis (Matsubayashi et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…In thyroid cancer patients with thyroiditis, a better survival rate was observed (Kashima et al, 1998). HLA-DR antigens are expressed on tumor cells and on peritumoral lymphocytes (Goldsmith et al, 1988;Feinmesser et al, 1996). The association of DTC with certain HLA-DR alleles was reported (Juhasz et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Establishment of the hu-PBL-SCID Mouse Model for the Investigation of Thyroid Cancer

Győry¹,

Mezősi²,

Szakáll³

et al. 2005

Exp Clin Endocrinol Diabetes

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New experimental models of human neoplastic diseases attempt to mimic the human environment that fostered the development of disease in cancer patients. The aim of the present study was to establish a human lymphocyte-engrafted, severe combined immunodeficient (hu-PBL-SCID) mouse model to investigate thyroid cancer and to evaluate the potential use of this model for cancer immunotherapy. Thyroid neoplastic tissues were obtained from ten patients (one follicular adenoma, five papillary, one follicular, one anaplastic and two medullary cancers). One 8 x 4 x 3 millimeter sample from each tumor was cut into two pieces of identical size and transplanted into two SCID mice. In each case, one of the two mice was injected intraperitoneally with lymphocytes from the same tumor patient for the reconstitution of the human immune system (Group A), while the other animal received no lymphocytes (Group B). The engraftment of the tumors was successful in all cases. The growth rate was highly dependent on the histological type. When histologies were compared before implantation and after the removal of the implants, the characters of the tumors proved to be unchanged, except one case where an anaplastic cancer arose from a papillary tumor. Macrophages were present in all but one papillary cancer. All differentiated thyroid cancers were infiltrated by T and B lymphocytes. Lymphocytes and macrophages disappeared from 19/20 grafts by week 16. However, in one case from group A lymphocytes were detected four months after the transplantation. In another case from group A, one papillary cancer spontaneously decreased in size and disappeared. Before implantation, HLA-DR expression was detected in every papillary cancer. HLA-DR expression in the grafts was not seen in 3/5 cases by week 16. In conclusion, an animal model has been established for the investigation of human thyroid cancer, by which the analysis of anti-tumor immunity, as a postulate of immune therapy, may be possible.

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HLA-DR expression and lymphocytic infiltration in metastatic and non-metastatic papillary carcinoma of the thyroid

Cited by 8 publications

References 16 publications

Differences in tumor cell proliferation, HLA DR expression and lymphocytic infiltration in various types of thyroid carcinoma

Differences in tumor cell proliferation, HLA DR expression and lymphocytic infiltration in various types of thyroid carcinoma

Clinicopathological Risk Factors for Distant Metastasis in Differentiated Thyroid Carcinoma: A Meta‐analysis

Establishment of the hu-PBL-SCID Mouse Model for the Investigation of Thyroid Cancer

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