HLA‐DR, DQ antigens in North American Caucasians

Abstract

HLA-DR, DQ specificities are determined by serological methods in 2,586 North American Caucasians. Antigen frequency, gene frequency and haplotype frequency are computed for each phenotype observed. The DR and DQ loci antigen distributions are well-fitted to a Hardy-Weinberg equilibrium (p greater than 0.25 for DR locus, p greater than 0.10 for DQ locus). All World Health Organization (WHO) recognized HLA-DR,DQ specificities were found except HLA-DRw18, which has been identified only in the black population. DR and DQ linkage disequilibria among recently defined splits is observed. The following DR and DQ associations are found: DR1 and DQw5; DR4 and DQw7, DQw8; DR7 and DQw2, DQw9; DR8 and DQw4, DQw6, DQw7; DR9 and DQw2, DQw9; DRw10 and DQw5; DRw11 and DQw6, DQw7; DRw12 and DQw5, DQw7; DRw13 and DQw6, DQw7; DRw14 and DQw5, DQW7; DRw15 and DQw6, DQw7; DRw16 and DQw5; DRw17 and DQw2. In this large study population, the following unusual DR and DQ associations are found: DR4, DQw2; DR4, DQw1; DR1, DQw7; DR7, DQw5; DRw17, DQw6; and other unusual haplotype phenotypes containing DRX, DQX.

Distribution of Polymorphie HLA-DR and -DQ Alleles as Determined by Restriction Fragment Length Polymorphism Analysis in an Austrian Population

“…They might give an insight in genetic relationships between different ethnic groups. Our results are in agreement with data from other Caucasian populations [36], however, the fre quencies for the DR 11 and DRw 52B specificities differ remarkably from frequencies of the Northern Ireland population [34],…”

Novel HLA‐DR2 and ‐DR3 haplotypes among Norwegian Caucasians

“…Unusual combinations of DRBl, DQAl and DQBl alleles may be found when a large number of individuals are investigated. For example, serological typing of DR and DQ antigens in 2586 North American Caucasians revealed unusual haplotypes in 0.2-2' 70 of the individuals (17). One of the exceptions of known linkage disequilibria was a possible DRwl7 (DRBl*0301)-DQw6 haplotype.…”

Molecular Genetic Analysis of HLA—DR and HLA—DQ Genes Among Anti—U1‐70‐kd Autoantibody Positive Connective Tissue Disease Patients

“…We analyzed the sequences of HLA-DRB genes present among the 27 patients for regions of homology, to determine if there were sequences that were common among patients, but not necessarily fixed to a single genotype. We compared the frequen- cies of these homologous regions with those in normal donors, using both our own and published data on DNA sequences and gene frequencies (25,26,28,38), with similar results.…”