HLA‐DR alleles associated with skin warts induced by human papillomavirus infection

García-Corona, Cristina; Vega‐Memije, Elisa; Barquera, Rodrigo; Granados, Julio

doi:10.1111/j.1365-4632.2010.04599.x

Cited by 6 publications

(10 citation statements)

References 10 publications

(24 reference statements)

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“…Accompanying features such as growth retardation and poor oral hygiene of our patients might have been facilitating factors. According to other studies [ 10 , 11 ], the major histocompatibility complex might contribute to the HPV infection, however HLA typing of our patients revealed an HLA DQB1*0301phenotype. HPV infection has attracted a great deal of attention, not just because of the difficulty of managing oral warts but also because of the oncogenic potential of certain strains [ 12 ].…”

Section: Discussioncontrasting

confidence: 48%

Oral HPV infection and MHC class II deficiency (A study of two cases with atypical outcome)

Dhouib¹,

Baccar²,

Mustapha

et al. 2012

Clin Mol Allergy

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BackgroundMajor histocompatibility complex class II deficiency, also referred to as bare lymphocyte syndrome is a rare primary Immunodeficiency disorder characterized by a profondly deficient human leukocyte antigen class II expression and a lack of cellular and humoral immune responses to foreign antigens. Clinical manifestations include extreme susceptibility to viral, bacterial, and fungal infections. The infections begin in the first year of life and involve usually the respiratory system and the gastrointestinal tract. Severe malabsorption with failure to thrive ensues, often leading to death in early childhood. Bone marrow transplantation is the curative treatment.Case reportsHere we report two cases with a late outcome MHC class II deficiency. They had a long term history of recurrent bronchopulmonary and gastrointestinal infections. Bone marrow transplantation could not be performed because no compatible donor had been identified. At the age of 12 years, they developed oral papillomatous lesions related to HPV (human papillomavirus). The diagnosis of HPV infection was done by histological examination. HPV typing performed on the tissue obtained at biopsy showed HPV type 6. The lesions were partially removed after two months of laser treatment.ConclusionsViral infections are common in patients with MHC class II and remain the main cause of death. Besides warts caused by HPV infection do not exhibit a propensity for malignant transformation; they can cause great psychosocial morbidity.

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Section: Discussioncontrasting

confidence: 48%

Oral HPV infection and MHC class II deficiency (A study of two cases with atypical outcome)

Dhouib¹,

Baccar²,

Mustapha

et al. 2012

Clin Mol Allergy

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“…HLA polymorphisms result in variations of peptide‐binding cleft, which may modify an adaptive immune response . The differences in binding affinities among HLA class II molecules were suggested to have a main role in the progression, persistence, and susceptibility to HPV infections . Studies in rabbits revealed that HLA class II antigens affect both regression and malignant transmission of cells infected with papillomavirus .…”

Section: Discussionmentioning

confidence: 99%

“…Their results suggested genetic variations in serological immune response to HPV infection. Only a few studies have recently focused on the association of HLA class II molecules and HPV‐induced mucocutaneous verrucous lesions because of their long‐lasting and therapy‐resistant properties . HLA DR3 and HLA DR9 alleles were considered to involve in persistence of the skin warts of Mexican patients, whereas HLA DR6 had a protective effect .…”

Section: Discussionmentioning

confidence: 99%

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Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family

Akoğlu¹,

Metin²,

Ceylan³

et al. 2014

Int J Dermatology

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“…Geographical location could explain the effect of UVR in view of its capacity to impair host immunity [Termorshuizen et al, ], and make fair‐skinned individuals more susceptible to skin cancers and probably susceptible to different Beta‐species. Race and ethnicity could explain the role of immunogenetics i.e., certain HLA class II alleles have shown preponderance in the development of skin cancers associated with HPV [Garcia‐Corona et al, ] and hence particular allele types may have a predilection to the carcinogenic activity of certain Beta‐species. Socioeconomic factors including access to health services, livelihood, and lifestyle may predispose to particular Beta‐species infection.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Betapapillomavirus infections among HIV infected and uninfected Black Zimbabweans with cutaneous lesions

Murahwa

Muchemwa

Duri

et al. 2014

Journal of Medical Virology

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Human papillomavirus (HPV) types from the Betapapillomavirus (β-HPV) genus are plentiful in non-melanoma skin cancers and warts among Caucasians, but there is paucity of information among black Africans. To determine the frequency of β-HPV genotypes in cutaneous infections among Black Zimbabweans, a cross-sectional study was carried out in which blood samples and skin biopsies were collected from patients infected and uninfected with HIV attending a referral hospital. We included 144 participants (72 infected and 72 uninfected with HIV) with clinically apparent cutaneous warts (n = 34), suspected non-melanoma skin cancers (n = 98) and Kaposi sarcoma (KS) (n = 18). The skin biopsies were analyzed for HPV DNA presence and type. β-HPV DNA was identified among 70% (101/144) and was significantly higher among patients infected with HIV, 79% (57/72) compared to the HIV uninfected 61% (44/72) [OR = 2.42, 95% CI (1.09-5.47), P = 0.018]. All patients with warts, 89% of those with KS and 58% of those with non-melanoma skin cancers were HPV DNA positive and β-HPV type 14 was identified in nearly half of the study participants 49.3% (71/144). Single HPV infections were observed in 33.7% (34/101) of the participants that were HPV DNA positive, 66.3% (67/101) had multiple HPV types. There was no significant difference between patients infected and uninfected with HIV in terms of multiple HPV infections. The distribution of different HPV types did not reveal any association with age and gender but there was an association between HPV 14 and HIV immune status. β-HPVs are not uncommon among the Black Zimbabweans with skin lesions.

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HLA‐DR alleles associated with skin warts induced by human papillomavirus infection

Abstract: This study follows the preponderant role of class II genes in the susceptibility or resistance to the development of skin warts caused by HPV infection.

Cited by 6 publications

References 10 publications

Oral HPV infection and MHC class II deficiency (A study of two cases with atypical outcome)

Oral HPV infection and MHC class II deficiency (A study of two cases with atypical outcome)

Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family

Frequency of Betapapillomavirus infections among HIV infected and uninfected Black Zimbabweans with cutaneous lesions

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