HLA‐DQB1 locus and gastric cancer in <i>Helicobacter pylori</i> infection

Watanabe, Yoshinori; Aoyama, Nobuo; Sakai, Toshiyuki; Shirasaka, Daisuke; Maekawa, Satoshi; Kuroda, Kohei; Wambura, Casmir; Tamura, Takao; Nose, Yoshisuke; Kasuga, Masato

doi:10.1111/j.1440-1746.2005.04112.x

Cited by 18 publications

(23 citation statements)

References 38 publications

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“…We did not find a positive association with DRB1*0405 in diffuse‐type GC. Our findings essentially agree with Watanabe et al ,14 in which the allele frequency of DQB1*0401 is higher in patients with intestinal‐type GC when compared with age‐ and sex‐matched H. pylori ‐infected NUD controls (19/36 = 52.8% vs . 15/49 = 30.6%, p < 0.05).…”

Section: Discussionsupporting

confidence: 93%

Novel pathways toward 5‐carbon bioplastics building blocks

2013

Biotech & Bioengineering

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It has been reported that polymorphisms of human leukocyte antigen (HLA) genes and several cytokine genes are associated with an increased risk of developing gastric cancer (GC). However, the results of studies from different geographic regions, ethnic groups and study groups are inconsistent. The aim of this study was to evaluate the influence of H. pylori infection and host genetic factors on GC susceptibility in Japanese patients with GC. We analyzed genotypes for HLA class I and II, tumor necrosis factor α, interleukin (IL)‐1β, IL‐1 receptor, IL‐4, IL‐4Rα and IL‐10 in 330 H. pylori‐infected noncardia patients with GC and 190 H. pylori‐infected nonulcer dyspeptic controls. Haplotype analyses indicated that the frequencies of the HLA DRB1*0405 and DQB1*0401 alleles were increased in the patients with intestinal‐type GC when compared with controls (both DRB1*0405 and DQB1*0401: p = 0.015, OR = 1.57, 95% CI = 1.09–2.26), but the changes were not statistically significant after correction for multiple comparisons. None of the cytokine gene polymorphisms were associated with GC susceptibility, whether patients with GC were analyzed as a group according to the histological subtype. Of interest was the comparison of controls and patients with intestinal‐type GC. The frequency of an IL‐10‐592AA homozygote showing concomitant carriage of the HLA DRB1*0405‐DQB1*0401 haplotype was significantly higher in patients with intestinal‐type GC (χ2 = 6.369, p = 0.0116, pc = 0.0464, OR = 2.43, 95% CI = 1.21–4.48). Our results suggest that the HLA class II and IL‐10‐592A/C polymorphisms synergistically affect the susceptibility to GC development of H. pylori‐infected individuals in the Japanese population. © 2009 UICC

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Section: Discussionsupporting

confidence: 93%

Novel pathways toward 5‐carbon bioplastics building blocks

2013

Biotech & Bioengineering

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“…Many studies related to HLA antigens in the literature have focused on screening of class II antigens especially in cancer cases (12,14) . Our study was the (10,11) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Gönen

Sarı

Kandur

et al. 2017

Arq. Gastroenterol.

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-Background -As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. Objective -The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. Methods -The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes. Results -The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003).

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“…A number of studies have reported associations of HLA alleles with malignant tumors caused by microbe infections (Li et al ., 2005; Watanabe et al ., 2006; Wu et al ., 2006). Human tumour cells express diverse types of antigens, depending on the aetiology and pathogenesis of the disease (Jager et al ., 2001).…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms of human leucocyte antigen‐DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese

Liu

Cheng

2007

Int J Immunogenetics

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To investigate whether human leucocyte antigen (HLA) class II DQA1 and DQB1 gene polymorphisms are associated with chronic hepatitis B virus (HBV) infection and development of HBV-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC), we detected the DQA1 and DQB1 allele polymorphisms in 168 HBV carriers (including 48 chronic hepatitis B, 42 LC and 78 HCC patients) and 100 controls who had recovered from HBV infection by using polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Our data suggest that DQA1*0102 and DQA1*0104 were associated with protection from chronic HBV infection (P(c) = 0.003) and development of LC (P(c) = 0.001), respectively, whereas DQB1*0201 conferred susceptible effect on chronic HBV infection (P(c) = 0.008). We also found that DQA1*0601, DQB1*0601 and DQA1*0201 showed some susceptible effect on chronic HBV infection and LC, respectively, however, these associations were no longer significant after Bonferroni correction (P(c) = 0.390, P(c) = 0.475 and P(c) = 0.140, respectively). No significant association has been found between DQA1 and DQB1 alleles and development of HCC. These results indicate that different subtypes of HLA-DQA1 and DQB1 are associated with development of chronic HBV infection and LC, respectively, in Han Chinese population.

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HLA‐DQB1 locus and gastric cancer in Helicobacter pylori infection

Cited by 18 publications

References 38 publications

Novel pathways toward 5‐carbon bioplastics building blocks

Novel pathways toward 5‐carbon bioplastics building blocks

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

Association of polymorphisms of human leucocyte antigen‐DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese

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