HLA-DQB1 and -DRB1 alleles, cytokine polymorphisms and KIR gene frequencies in a population (Caucasian) from South East Brazil

HLA‐DRB1*04:02, DRB1*08:04 and DRB1*14 alleles associated to pemphigus vulgaris in southeastern Brazilian population

“…One hundred sixty‐two unrelated individuals were randomly chosen from the data bank (preserving the same ethnicity proportions of study group) and formed the control group. The allele frequencies found in the control group were similar to those reported by previous studies in samples of population from southeastern Brazil (7–9). Unlike other researchers, the authors of this study decided to not select individuals – cases or controls – from a homogeneous ethnic group, based on the premise that the Brazilian population is one of the most heterogeneous populations in the world as a result of five centuries of admixture between Europeans, Africans, and Amerindians, which produces, at the individual level, a significant dissociation of color and genomic ancestry (10).…”

HLA-A, -B, and -DRB1 allelic and haplotypic diversity in a sample of bone marrow volunteer donors from Rio Grande do Sul State, Brazil

“…Information on the ancestors of each individual is required to identify the inherited haplotypes and thus inform the true distribution. Characterization of the haplotypes allows identification of the ethnic influence in different Table 3 The 10 most common allelic groups in the total sample (n ϭ 5,000) for each locus and their comparisons between samples from different Brazilian regions HLA locus Total PR [8] SP [11] MG [14] PI [15] PE [16] Total ϫ PR (p value) [8]. By contrast, we have observed variations in the frequencies of these haplotypes according to the ethnic group assessed in our sample.…”

“…All donors signed an informed consent. The samples used for comparisons between different Brazilian states and their characteristics were as follows: Paran (n ϭ 3,500, Caucasians, blacks, Orientals, and mestizos) [8], SÄo Paulo (n ϭ 103, Caucasians) [11], Minas Gerais (n ϭ 95, Caucasians) [14], PiauÎ (n ϭ 97, mestizos) [16], and Pernambuco (n ϭ 101, Caucasians and non-Caucasians) [17]. These studies were selected because they are the most recent publications on the Brazilian population that facilitate comparison because they all use molecular typing methods.…”

Diretrizes brasileiras para o diagnóstico de narcolepsia

“…7,12,13,73 However, the presence of this allele is not a sufficient or necessary factor for the development of narcolepsy. 7,73 In the general population, the prevalence of the HLA-DQB1*0602 antigen varies between 12% and 34% 8,14,15 ( Table 1). In narcolepsy without cataplexy, the HLA-DQB1*0602 prevalence rate is 40% to 60%.…”