HLA DQA1*0501 and DQB1*02 in Cuban Celiac Patients

Cintado, Alberto; Sorell, Luis; Galván, José A.; Martínez, Luis Trapiella; Castañeda, Carlos; Fragoso, T; Camacho, Hanlet; Ferrer, Annia; Companioni, Osmel; Benítez, Jesús; Nazabal, Marcelo; Novoa, Lidia I; Dueñas, Marta

doi:10.1016/j.humimm.2006.04.009

Cited by 18 publications

(15 citation statements)

References 21 publications

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“…In the United States, a greater proportion of HLA DQ8 and a smaller proportion of DQ2 than in Europe have been reported. 9 HLA DQ2 and DQ8 frequencies similar to those observed in the USA have been described in Asian10, Cuban11 and Chilean12 populations.…”

Section: Introductionsupporting

confidence: 68%

“…Butterworth et al, in England, demonstrated that patients of Indian origin had lower frequency of HLA DQ2 than those of British origin 10. Lower frequencies of HLA DQ2 and higher frequency of HLA DQ8 than European have also been described among celiac disease patients in the United States (82% DQ2 and 16% DQ8 only) and in Cuba (86% DQ2) 11,17 …”

Section: Discussionmentioning

confidence: 94%

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Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

Antunes

Crovella

Brandão³

et al. 2011

Clinics

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AIMS:The aim of this study was to evaluate the frequencies of the HLA genotypes DQ2 and DQ8 and the alleles A1*05, A1*0201, B1*0201 and B1*0302 in individuals with celiac disease in Recife, northeastern Brazil.METHODS:HLA DQ2 and DQ8 genotyping was performed for 73 individuals with celiac disease and 126 first-degree relatives with negative transglutaminase serology. The alleles DQA1*05, DQA1*0201, DQB1*02 and DQB1*0302 were identified by sequencing using specific primers and the EU-DQ kit from the Eurospital Laboratory, Trieste, Italy and double-checked by the All Set SPP kit (Dynal).RESULTS:Among the 73 cases, 50 (68.5%) had the genotype DQ2, 13 (17.8%) had DQ8, 5 (6.8%) had DQ2 and DQ8, and 5 did not have any of these genotypes. Among the 5 negative individuals, four had the B1*02 allele and one did not have any of the alleles studied. B1*02 was the most frequent allele in both groups (94% in the patients and 89% in the control relatives).CONCLUSIONS:In this study, celiac disease was associated with the genotypes DQ2 and DQ8. DQ2 predominated, but the distribution of the frequencies was different from what has been found in European populations and was closer to what has been found in the Americas. The high frequencies of the HLA genotypes DQ2 and DQ8 that were found in first-degree relatives would make it difficult to use these HLA genotypes for routine diagnosis of celiac disease in this group.

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Section: Introductionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 94%

Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

Antunes

Crovella

Brandão³

et al. 2011

Clinics

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“…The LA population presents with a notable racial, genetic, and cultural diversity [ 17 ]. Therefore in LA, some countries such as Argentina, Brazil, Chile, Cuba, Uruguay and Venezuela, have > 50% of Caucasian component, and certain regions within these nations are more Caucasian than others [ 111 , 125 ]. The highest prevalence of CD has been reported in those countries with a high Caucasian admixture ( S1 Table ).…”

Section: Discussionmentioning

confidence: 99%

“…During the search, we found that some studies have reported the presence of HLA-DQ2 and HLA-DQ8 haplotype in the LA population with high titers of CD autoantibodies and diagnosis of CD ( Table 4 ) [ 12 , 85 , 88 , 111 , 136 – 141 ]. HLA DQ2.5 is common in the LA population, whilst approximately 90% of studied Amerindian individuals carry the DQ8 haplotype [ 14 , 142 , 143 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression

et al. 2015

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BackgroundCeliac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis.Methods and FindingsThis was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46% and 0.64%. The prevalence of CD in first-degree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies).ConclusionsAlthough CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.

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“…Por outro lado, a prevalência de DQ8 nas crianças celíacas da população estudada (19%) foi maior que a descrita na Europa e similar à encontrada nos Estados Unidos, Cuba e América do Sul(62,118,121,122).No entanto, a prevalência de variantes predisponentes no grupo de crianças não celíacas foi semelhante à achada em estudos feitos na população geral em diversos países europeus(101,114). Dados similares tinham sido descritos por Almeida (123) em estudo feito com recém-nascidos da mesma região do Brasil.A prevalência das variantes alélicas que codificam para o heterodimero HLA-DQ2 (80%) apresentou o mesmo padrão de similaridade com populações não Europeias quando a única variante considerada relevante foi DQ2.5(62,118,121,122).Os dados obtidos mediante as técnicas de qPCR e PCR-SSP apresentaram 100% de concordância. Porém, o método desenvolvido no nosso laboratório conseguiu combinar a simplicidade técnica da qPCR, com menor tempo para obtenção de resultados e menor número de passos para sua execução, com a especificidade dos primers SSP.…”

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Prevalência de alelos HLA predisponentes para a doença celíaca (HLA-DQ2 e HLA-DQ8) em crianças celíacas e não celíacas

Selleski¹

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Agradeço primeiramente aos meus pais (Laura e Tito) por ter me criado com muito amor y paciência, por ter me dado uma boa educação e incentivado a cumprir meus sonhos. Agradeço à minha irmã Michelle por ser a minha companheira de vida, uma amiga incondicional e cúmplice nos momentos mais felizes e nos mais difíceis também. Ao meu orientador professor Dr. Riccardo Pratesi por ter me dado a oportunidade de cumprir meu sonho e ter me guiado e compartilhado todos os seus conhecimentos nesse curto tempo. Aprendi muito com ele tanto do âmbito laboral como da vida em geral, um verdadeiro exemplo. À professora Dr. Lenora Gandolfi por ter me recebido e integrado com tanto carinho. Por me permitir fazer parte do mundo da doença celíaca, desde o ambulatório e laboratório. Por ter compartilhado todos os seus conhecimentos e ampla experiência comigo, me ensinando com muita paciência e dedicação. À professora Dr. Yanna Karla de Medeiros Nóbrega por ter me ajudado muito inclusive antes de me conhecer, por ter me recebido com muito carinho e ensinado e guiado durante esses dois anos compartilhando seus conhecimentos. Agradeço aos meus colegas e amigos do laboratório por me deixarem fazer parte desse lindo grupo multidisciplinar que enriquece muito meus conhecimentos e que com muito carinho me ajudam a fazer de cada dia, um dia melhor:

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HLA DQA10501 and DQB102 in Cuban Celiac Patients

Cited by 18 publications

References 21 publications

Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

Fequency distribution of HLA DQ2 and DQ8 in celiac patients and first-degree relatives in Recife, northeastern Brazil

Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression

Prevalência de alelos HLA predisponentes para a doença celíaca (HLA-DQ2 e HLA-DQ8) em crianças celíacas e não celíacas

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