HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity

Xue, Ailing; Chapoval, Svetlana P; Finn, E.S.; Chowdhary, Vaidehi; Marietta, Eric; Gaffey, Thomas A.; Pursifull, A.C.; David, Chella S.

doi:10.1016/j.clim.2005.08.003

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…38 Data obtained in occupational studies identify HLA class II molecules as prominent factors for the specificity of the response to occupational agents having either LMW or HMW, including polyisocyanates and prepolymers, Western red cedar, acid anhydrides, chlorinated platinum salts, natural rubber latex, detergent enzymes, and animal proteins. [39][40][41][42][43][44][45][46][47][48] In a study of diisocyanate-induced asthma in northern Italy, the frequencies of DQA1*0104 and DQB1*0503 were significantly higher in subjects with asthma than in asymptomatic exposed subjects, whereas DQA1*0101 and DQB1*0501 were significantly higher in asymptomatic exposed subjects. 40 The 2 DQB1 alleles, DQB1*0503 and DQB1*0501, differ in a single position, amino acid 57, with aspartic acid in the first and valine in the second.…”

Section: Genetic Aspectsmentioning

confidence: 96%

Mechanisms of occupational asthma

Maestrelli

Boschetto

Fabbri

et al. 2009

Journal of Allergy and Clinical Immunology

189

148

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Section: Genetic Aspectsmentioning

confidence: 96%

Mechanisms of occupational asthma

Maestrelli

Boschetto

Fabbri

et al. 2009

Journal of Allergy and Clinical Immunology

189

148

View full text Add to dashboard Cite

“…Data obtained in occupational studies identify HLA class II molecules as prominent factors for the specificity of the response to occupational agents having either LMW or HMW, including polyisocyanates and prepolymers, Western Red Cedar, acid anhydrides, chlorinated platinum salts, natural rubber latex, detergent enzymes, and animal proteins. [68][69][70][71][72][73][74][75][76][77][78] While some studies demonstrate significant association between several leukocyte antigen genes and asthma, other studies have failed to replicate these associations raising doubts about their generalizability to the population at large or use as diagnostic or prognostic tools. 79,80 The difference in conclusion between studies could be a result of sample size, asthma definitions used, and geographic difference between study populations.…”

Section: Role Of Genetics In Occupational Asthmamentioning

confidence: 99%

Occupational Asthma and Work-Exacerbated Asthma

Friedman‐Jiménez

Harrison

Luo

2015

Semin Respir Crit Care Med

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Occupational asthma (OA) and work-exacerbated asthma (WEA), collectively known as work-related asthma (WRA), have been recognized as the most prevalent work-related lung diseases in the industrialized world. OA is asthma caused by workplace conditions, and is subdivided into sensitizer-induced (allergic) OA and irritant-induced (nonallergic) OA. WEA is asthma that is made worse, but was not initially caused, by workplace conditions. Although WRA is rarely fatal, patients with WRA frequently experience excessive time lost from work, workplace-specific severe disability, loss of income, job loss, and related psychosocial and financial problems. More than 400 workplace environmental agents have been reported to cause WRA, and are classified by molecular weight and allergenic and irritant properties. Diagnosis of WRA requires confirmation of a diagnosis of asthma plus evidence that the asthma was caused or worsened by workplace conditions. Accuracy of diagnosis is important because either overdiagnosis or missed diagnosis of WRA can be problematic for the patient. Self-reported clinical symptoms alone have only fair sensitivity and specificity for OA. If possible, diagnostic assessment should also include objective evidence with functional and immunologic testing. Treatment and prevention of onset or worsening of WRA can be highly effective and typically include both optimal medical management (generally the same as for non-WRA) and, importantly, avoidance of sensitizer or irritant exposures that caused or exacerbate the asthma. In most cases of OA, prognosis is better with cessation rather than reduction of exposure, and this may require substantial changes in the workplace environment or change of job or even profession.

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“…Protease activity of enzymes may provide strong immunological (danger) signal promoting development of IgE-mediated airway allergies (Porter et al ., 2011). Expressing the HLA-DQ8 polymorphism may be associated with genetically increased susceptibility to develop sensitization and airway allergies to subtilisins (Xue et al ., 2005). …”

Section: Subtilisinsmentioning

confidence: 99%

Experiences from Occupational Exposure Limits Set on Aerosols Containing Allergenic Proteins

Nielsen

Larsen

Hansen

et al. 2012

The Annals of Occupational Hygiene

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Occupational exposure limits (OELs) together with determined airborne exposures are used in risk assessment based managements of occupational exposures to prevent occupational diseases. In most countries, OELs have only been set for few protein-containing aerosols causing IgE-mediated allergies. They comprise aerosols of flour dust, grain dust, wood dust, natural rubber latex, and the subtilisins, which are proteolytic enzymes. These aerosols show dose-dependent effects and levels have been established, where nearly all workers may be exposed without adverse health effects, which are required for setting OELs. Our aim is to analyse prerequisites for setting OELs for the allergenic protein-containing aerosols. Opposite to the key effect of toxicological reactions, two thresholds, one for the sensitization phase and one for elicitation of IgE-mediated symptoms in sensitized individuals, are used in the OEL settings. For example, this was the case for flour dust, where OELs were based on dust levels due to linearity between flour dust and its allergen levels. The critical effects for flour and grain dust OELs were different, which indicates that conclusion by analogy (read-across) must be scientifically well founded. Except for subtilisins, no OEL have been set for other industrial enzymes, where many of which are high volume chemicals. For several of these, OELs have been proposed in the scientific literature during the last two decades. It is apparent that the scientific methodology is available for setting OELs for proteins and protein-containing aerosols where the critical effect is IgE sensitization and IgE-mediated airway diseases.

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HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity

Cited by 6 publications

References 48 publications

Mechanisms of occupational asthma

Mechanisms of occupational asthma

Occupational Asthma and Work-Exacerbated Asthma

Experiences from Occupational Exposure Limits Set on Aerosols Containing Allergenic Proteins

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