HLA‐DQ3 is associated with idiopathic guttate hypomelanosis, whereas HLA‐DR8 is not, in a group of renal transplant patients

Abstract

The presence of HLA-DQ3 in patients with IGH suggests a genetic basis in a group of renal transplant subjects. HLA-DR8 was found in patients without IGH, and it could play a role as a "protective factor" preventing subjects from developing IGH.

Clinical features of idiopathic guttate hypomelanosis in 646 subjects and association with other aspects of photoaging

“… 10 revealed a highly statistically significant preponderance of manifestations of IGH among the relatives of IGH subjects compared with those of normal controls, which clearly indicated a family aggregation among subjects with IGH. In a group of 22 Columbian renal transplant patients, HLA‐DQ3 was found to be significantly associated with IGH 14 . In this study, only 7% of our patients identified IGH lesions occurring in family members.…”

Comprehensive understanding of idiopathic guttate hypomelanosis: clinical and histopathological correlation

“…The exact mechanism underlying IGH is unclear. Genetic factors such as HLA‐DQ3, chronic sun exposure, trauma, and autoimmunity have been suggested as causative factors 2,3,12–14 . The appearance of small and large leukodermic spots in patients irradiated with high‐intensity UVA and psoralens, over a relatively short period of time, and the finding of IGH lesions on the more exposed areas of the upper and lower extremities, raises the question of a possible role of chronic natural UV light exposure as one of the causative factors 11 .…”

Disorders of pigmentation

“…339,340 Repigmentation does not occur. In a group of renal transplant patients, the presence of this condition correlated with the presence of HLA-DQ3 341. In a group of renal transplant patients, the presence of this condition correlated with the presence of HLA-DQ3 341.…”