HLA-DPB1 and Epstein-Barr virus gp42 protein jointly contribute to the development of Hodgkin lymphoma

Li, Hongyu; Liu, Dan; Li, Xun

doi:10.21037/tcr-20-2070

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…The role of the HLA-DPB1 has gained greater relevance due to its association with various pathologies, including cancer ( 59 ), autoimmune diseases, such as rheumatoid arthritis ( 60 ), responses to viral infection ( 61 ), and vaccines ( 62 , 63 ). Regarding stem cell transplants, there is still controversy about the inclusion of the HLA-DPB1 locus in the search algorithms for 12/12 histocompatibility ( 64 ) due to the increasing number of reports indicating that a mismatch in this locus increases the risk of developing GVHD ( 65 ).…”

Section: Discussionmentioning

confidence: 99%

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Hernández¹,

Páez-Gutiérrez²,

Ardón³

et al. 2023

Front. Immunol.

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The HLA compatibility continues to be the main limitation when finding compatible donors, especially if an identical match is not found within the patient’s family group. The creation of bone marrow registries allowed a therapeutic option by identifying 10/10 compatible unrelated donors (URD). However, the availability and frequency of haplotypes and HLA alleles are different among ethnic groups and geographical areas, increasing the difficulty of finding identical matches in international registries. In this study, the HLA-A, -B, -C, -DRB1, and -DQB1 loci of 1763 donors registered in the Colombian Bone Marrow Registry were typed by next-generation sequencing. A total of 52 HLA-A, 111 HLA-B, 41 HLA-C, 47 HLA-DRB1, and 20 HLA-DQB1 alleles were identified. The 3 most frequent alleles for each loci were A*24:02g (20,8%), A*02:01g (16,1%), A*01:01g (7.06%); B*35:43g (7.69%), B*40:02g (7.18%), B*44:03g (6.07%); C*04:01g (15.40%), C*01:02g (10.49%), C*07:02g (10.44%); DRB1*04:07g (11.03%), DRB1*07:01g (9.78%), DRB1*08:02g (6.72%); DQB1*03:02g (20.96%), DQB1*03:01g (17.78%) and DQB1*02:01g (16.05%). A total of 497 HLA-A-C-B-DRB1-DQB1 haplotypes were observed with a frequency greater than or equal to 0.05% (> 0.05%); the haplotypes with the highest frequency were A*24:02g~B*35:43g~C*01:02g~DQB1*03:02g~DRB1*04:07g (3.34%), A*29:02g~B*44:03g~C*16:01g~DQB1*02:01g~DRB1*07:01g (2.04%), and A*01:01g~B*08:01g~C*07:01g~DQB1*02:01g~DRB1*03:01g (1.83%). This data will allow the new Colombian Bone Marrow Donor Registry to assess the genetic heterogeneity of the Colombian population and serve as a tool of interest for future searches of unrelated donors in the country.

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Section: Discussionmentioning

confidence: 99%

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Hernández¹,

Páez-Gutiérrez²,

Ardón³

et al. 2023

Front. Immunol.

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“…The exact pathogenic mechanisms of infectious mononucleosis remain incon- (LMPs), EBV Nuclear Antigens (EBNAs), and a small amount of small noncoding RNAs. These proteins help maintain the latent state while also promoting the survival and proliferation of infected B cells post-infection [12] [13].…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

Research Advances in Infectious Mononucleosis Caused by Epstein-Barr Virus

Wang,

Chen

2024

OJPed

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Infectious mononucleosis (IM), primarily caused by the Epstein-Barr virus (EBV), manifests as the classic triad of fever, pharyngitis, and cervical lymphadenopathy. Severe cases may involve organ damage, most commonly affecting the liver. Diagnosis relies on a combination of clinical presentation and laboratory parameters, with commonly used indicators including EBVspecific antibodies, EBV-DNA load, and the ratio of atypical lymphocytes. Treatment primarily involves symptomatic supportive care, with a cautious approach to the routine use of antiviral medications. In recent years, significant research in traditional Chinese medicine has been conducted in China, showing promising advancements. This article provides a comprehensive review of EBV-induced infectious mononucleosis, offering insights for clinical diagnosis and treatment.

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“…[117] The correlation was further utilized to measure the electrochemical impedance spectroscopy of single nanoparticles. [118] The injection of electrons to a graphene monolayer was also found to expand its dimension [119] and to change its optical conductivity. [120] Both effects can be detected by using optical imaging approaches.…”

Section: Optical Electrochemical Imagingmentioning

confidence: 99%

“…Despite of the critical roles of impedance measurements in traditional electrochemistry, efforts on single nanoparticle impedance spectroscopy are still rare. [118] The incorporation of temporal (frequency) dimension in impedance spectroscopy should provide valuable information to decouple multiple electron transfer processes including electrode-nanoparticle contacts, double-layer charging, ionic migration and electron hopping within the nanoparticles. From another aspect, great efforts are also demanded to improve the capability for in situ characterizing the structural feature of single nanoparticles.…”

Section: Perspectivementioning

confidence: 99%

Single-entity electrochemistry at confined sensing interfaces

et al. 2020

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Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes. Recent advances in the chemical measurement provide a means for ultra-sensitive analysis. Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity. In this review, we summarize the recent progress in single-entity electrochemistry of single molecules, single particles, single cells and even brain analysis. The benefits of confining these entities to a compatible size sensing interface are exemplified. Finally, the opportunities and challenges of single entity electrochemistry are addressed.

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HLA-DPB1 and Epstein-Barr virus gp42 protein jointly contribute to the development of Hodgkin lymphoma

Cited by 6 publications

References 31 publications

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing

Research Advances in Infectious Mononucleosis Caused by Epstein-Barr Virus

Single-entity electrochemistry at confined sensing interfaces

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