HLA-DPB1 and anti-HBs titer kinetics in hepatitis B booster recipients who completed primary hepatitis B vaccination during infancy

Abstract

Previously we reported significant associations of the human leukocyte antigen (HLA)-DPB1 05:01 with memory against hepatitis B (HB) vaccination. However, the effects of HLA-DPB1 on antibodies to hepatitis B surface antigen (anti-HBs) kinetics were not explored. We followed up a cohort of 1974 HB booster recipients and quantified their 1-month and 1-year post-booster anti-HBs titers. A total of 681 subjects were randomly selected and typed for HLA-DPB1. We found that male subjects, undetectable pre-booster titers, and 05:01 homozygotes led to significantly lower post-booster anti-HBs titers. The geometric means (95% confidence interval (CI)) of 1-month post-booster anti-HBs titers were 4.68 (2.69-8.12), 23.01 (14.96-35.40) and 50.06 (27.20-92.13) mIU ml(-1) for subjects carrying two, one and no HLA-DPB1 05:01 allele. The corresponding figures for 1-year post-booster anti-HBs titers were 1.26 (0.73-2.18), 4.72 (3.08-7.25) and 7.32 (3.75-13.56) mIU ml(-1). There were significant associations of post-booster anti-HBs titers with the number of HLA-DPB1 risk and protective alleles. Among booster responders, anti-HBs decay rates were significantly reduced in subjects who had detectable pre-booster anti-HBs titers and the HLA-DPB1 05:01 allele. Our results indicated that HLA-DPB1 influences the kinetics of anti-HBs. The long-term memory against hepatitis B surface antigen (HBsAg) and the residual serum titers of anti-HBs after HB vaccination may be influenced by different mechanisms as evidenced by their inverse trend of associations with the 05:01 allele.

HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

“…HLA-DPB1*05:01 has also been shown to be more common in individuals who do not develop seroprotection after hepatitis B vaccination. 56 We also observed consistent associations of HLA class I alleles HLA-A*11:01, HLA-B*35:03, and HLA-B*51:01 (predisposing) after correction of all HLA class II effects, suggesting an independent role for these HLA alleles. These findings are similar to those found in other autoimmune diseases, such as MS 32,57,58 or type 1 diabetes, 59 where the main risk alleles are located in the HLA class II region but residual association is seen in HLA class I.…”

Association of HLA-DPA1, HLA-DPB1, and HLA-DQB1 Alleles With the Long-Term and Booster Immune Responses of Young Adults Vaccinated Against the Hepatitis B Virus as Neonates

“…Further large-scale studies are required to provide more concrete data. Nevertheless, the results of this study may be incorporated into other research to broaden the understanding of the immune response of the HBV vaccine among young Taiwanese adults (24,34,40). Third, as a result of limited funding, we did not test HLA-DR, despite extensive studies both domestically and internationally (20,23,(26)(27)(28)(29) reporting a strong linkage disequilibrium between HLA-DR and -DQ alleles.…”

Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

“…HLA-DRB1 *11, HLA-DQB1 *0301 and HLA-DRB1 *07 were found to be associated with HCV clearance or persistence, and HLA-DPA1 *0103, HLA-DPB1 *0402 and HLA-DPB1 *0501 were found to be candidate predictive factors for antibody production after HBV vaccination [51,52,53]. Moreover, Bain et al previously identified a specific CD8 + memory T cell response for HLA-A2 and/or HLA-B7 predicted epitopes derived from the HCV F protein in patients with HCV natural infection [16].…”