HLA class II polymorphism in Thais detected by PCR‐SSO and PCR‐RFLP

Sujirachato, K; Chiewsilp, P; Tsuji, Kimiyoshi; Inoko, Hidetoshi; Panyim, Sakol; Mongkolsuk, T; Leetrakool, Nipapan

doi:10.1111/j.1399-0039.1994.tb02329.x

Cited by 12 publications

(11 citation statements)

References 16 publications

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“…The DRB1–DQB1 association in NE‐Thais is quite similar to those found in Chinese, Buyi, Dai, Vietnamese, Thais and Singapore‐Chinese (Olerup et al , 1992; Imanishi et al , 1992; Sun et al , 1992). The most common haplotype is DRB1 * 1502‐DQB1 * 0501 , which is different from that found in previous studies on Thais (Sujirachato et al , 1994) and Vietnamese ( DRB1*1202‐DQB1*0301 ). However, DRB1 * 1502‐DQB1 * 0501 was observed in Buyi, Dai, Vietnamese and Thais (Imanishi et al , 1992).…”

Section: Discussioncontrasting

confidence: 99%

“…DRB1 * 1303 was always found with DQB1 * 0301/0304 and DRB1 * 0403 was always detected with DQB1 * 0302 . The haplotype DRB1 * 1501‐DQB1 * 0601 reported in this study has not been found in Caucasians but was also found in Chineses and Thais (Imanishi et al , 1992; Wang et al , 1993; Sujirachato et al , 1994). The haplotype DRB1 * 1303 ‐ DQB1 * 0301/0304 was also found in Buyi (Imanishi et al , 1992).…”

Section: Discussionsupporting

confidence: 42%

“…DRB1 * 1301, 1407, 0401, 0404 and 1001 were rare, being found only once in the samples. DRB1 * 01 alleles were absent in the NE‐Thais and in the other Thai populations (Sujirachato et al , 1994; Chandanayingyong et al , 1997). Eleven DQB1 alleles were defined.…”

Section: Resultsmentioning

confidence: 88%

“…Data from NE‐Thais, Central Thais (Sujirachato et al , 1994), present‐day Thais (PDT), Dai Lue (Chandanayingyong et al , 1997), Buyi (Imanishi et al , 1992) South and North Chinese (Sun et al , 1992) and Vietnamese (Clayton et al , 1997) were compared. Several alleles have similar distribution patterns in South‐east Asians.…”

Section: Discussionmentioning

confidence: 99%

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Distributions of HLA‐DRB1/DQB1 alleles and haplotypes in the North‐eastern Thai population: indicative of a distinct Thai population with Chinese admixtures in the Central Thais

Puapairoj

Romphruk

Barasrux

et al. 1999

European Journal of Immunogenetics

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HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in population-based Swedish patients and controls aged 0-34 years. The age dependence of HLA-associated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at onset in the relative risk for the positively associated DQB1*0201-A1*0502/B1*0302-A1*0301 (DQ2/8) genotype (P = 0.02) and the negatively associated DQB1*0602-A1*0102 (DQ6.2) haplotype (P = 0.004). At birth, DQ6.2-positive individuals had an estimated relative risk of 0.03, but this increased to 1.1 at age 35 years. Relative risks for individuals with DQ genotype 8/8 or 8/X or DQ genotype 2/2 or 2/X, where X is any DQ haplotype other than 2, 8 or 6.2, were not significantly age-dependent. An exploratory analysis of DQ haplotypes other than 2, 8 and 6.2 suggested that the risk of type 1 diabetes increases with age for DQB1*0604-A1*0102 (DQ6.4) and that the peak risk for the negatively associated DQB1*0301-A1*0501 haplotype is at age 18 years. There was also weak evidence that the risk for DQB1*0303-A1*0301 (DQ9), which has a positive association in the Japanese population, may decrease with age. We speculate that HLA-DQ alleles have a significant effect on the rate of beta cell destruction, which is accelerated in DQ2/8-positive individuals and inhibited, but not completely blocked, in DQ6.2-positive individuals.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 42%

Section: Resultsmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Distributions of HLA‐DRB1/DQB1 alleles and haplotypes in the North‐eastern Thai population: indicative of a distinct Thai population with Chinese admixtures in the Central Thais

Puapairoj

Romphruk

Barasrux

et al. 1999

European Journal of Immunogenetics

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“…Table 3 compares the polymorphism of the Muongs to nine other Asian populations at the DRB1 level using Edwards genetic distance measurement. Three distinct groups can be observed: (i) where the Muongs appeared to be closest to Dai Lue ( 9 ) and Buyi ( 9 ), (ii) much more distant from this group, three Chinese populations were found from the Shanghai sample ( 11 ) and two from the North of China samples ( 12, 13 ), which were close together, and (iii) four other populations constitute an intermediate group: Kinh ( 1 ), North‐eastern Thais ( 2 ), Central Thais ( 10 ) and present days Thais of Bangkok ( 9 )…”

Section: Resultsmentioning

confidence: 99%

HLA‐DRB1 and DQB1 allele distribution in the Muong population exposed to malaria in Vietnam

Busson

Trieu²,

LaBelle

et al. 2002

Tissue Antigens

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The distribution of 30 HLA-DRB1 alleles in 85 individuals and of 10 HLA-DQB1 alleles in 91 individuals of the Viet Muong population was studied and compared with those of nine other Asian populations, including 103 Viet Kinh belonging to the major ethnic group in Vietnam. In terms of genetic distance, our data are consistent with a close ethnogeographic relationship between Viet Muong, Buyi and Dai Lue, two Southern Chinese ethnic groups. Conversely, these three populations are distant from the Northern Chinese population. The Viet Kinh belong to an intermediate group, together with North-eastern Thais, Thais and present day Thais. The striking presence of the HLA-DQ1*0502 allele (48% frequency) in the Viet Muongs is possibly anthropological or environmental in origin: the Viet Muongs have been submitted to endemic malaria for centuries, and the survivors carry the protective trait of glucose-6-phosphate dehydrogenase deficiency. This raises the hypothesis of a possible resistance to lethal or severe forms of the disease, where the association with a specific HLA-DQB1 allele may play a role.

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