HLA class II polymorphism in Latin American patients with multiple sclerosis

Rojas, Olga L.; Rojas-Villarraga, Adriana; Cruz‐Tapias, Paola; Sánchez, Jorge; Suárez-Escudero, Juan Camilo; Patarroyo, Manuel A.; Anaya, Juan Manuel

doi:10.1016/j.autrev.2009.11.001

Cited by 41 publications

(19 citation statements)

References 39 publications

(54 reference statements)

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“…There is growing evidence that genetic factors might play vital roles in MS development. Human leukocyte antigen (HLA), for example, has been widely reported to have a strong effect on MS 11, 41, 42 . IL7RA, on the other hand, serves as the first non-HLA gene that was also determined to have an association with MS susceptibility 17, 21, 23, 43 .…”

Section: Discussionmentioning

confidence: 99%

Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls

Liu

Huang²,

Dou

et al. 2017

Sci Rep

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Recently, numerous genome wide association studies (GWAS) and other case-control association studies examining the relationship between interleukin-7 receptor α chain (IL7RA) gene rs3194051, rs987107, rs11567686, and rs11567685 variants and multiple sclerosis (MS) risk have been conducted, but the conclusions have been inconsistent. The main objective of this meta-analysis was to more precisely explore the association of these four IL7RA variants with MS development. Twenty-seven eligible studies involving 9734 cases and 10436 controls were included in the present meta-analysis. Power calculation, publication bias, sensitivity analysis and cumulative meta-analysis were performed to derive a reliable conclusion. Our study indicated three IL7RA loci were significantly associated with increasing MS risk (rs3194051: recessive model: OR = 1.22, 95% CI 1.08–1.38; rs987107: recessive model: OR = 1.44, 95% CI 1.22–1.69; and rs11567686: dominant model: OR = 1.18, 95% CI 1.01–1.37). Additionally, IL7RA rs11567685 variants might not be related to MS development. In all, IL7RA locus polymorphisms could play an important role in the predisposition to MS, which could contribute to a better understanding the pathogenesis of multiple sclerosis.

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Section: Discussionmentioning

confidence: 99%

Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls

Liu

Huang²,

Dou

et al. 2017

Sci Rep

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“…This is the case for SLE, SS, and T1D that have the DRB1*03:01 allele as a risk factor [30, 45, 46]. Furthermore, in diseases that are distant in our clustering analysis, such as MS and T1D, the same DQB1*06:02 allele gives protection to the first but risk to the second disease [47]. …”

Section: Discussionmentioning

confidence: 99%

The Autoimmune Tautology: An In Silico Approach

Cifuentes

Restrepo-Montoya

Anaya

2012

Autoimmune Diseases

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There is genetic evidence of similarities and differences among autoimmune diseases (AIDs) that warrants looking at a general panorama of what has been published. Thus, our aim was to determine the main shared genes and to what extent they contribute to building clusters of AIDs. We combined a text-mining approach to build clusters of genetic concept profiles (GCPs) from the literature in MedLine with knowledge of protein-protein interactions to confirm if genes in GCP encode proteins that truly interact. We found three clusters in which the genes with the highest contribution encoded proteins that showed strong and specific interactions. After projecting the AIDs on a plane, two clusters could be discerned: Sjögren's syndrome—systemic lupus erythematosus, and autoimmune thyroid disease—type1 diabetes—rheumatoid arthritis. Our results support the common origin of AIDs and the role of genes involved in apoptosis such as CTLA4, FASLG, and IL10.

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“…DRB1*1501 and DQB1*0602 were found to be high risk factors for MS [55]. No onset relationship was described, but high risk factor allele DQB1*0602 is thought to be protective in T1D.…”

Section: Multiple Sclerosismentioning

confidence: 99%

How Does Age at Onset Influence the Outcome of Autoimmune Diseases?

Amador-Patarroyo

Rodríguez

Montoya-Ortiz

2012

Autoimmune Diseases

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The age at onset refers to the time period at which an individual experiences the first symptoms of a disease. In autoimmune diseases (ADs), these symptoms can be subtle but are very relevant for diagnosis. They can appear during childhood, adulthood or late in life and may vary depending on the age at onset. Variables like mortality and morbidity and the role of genes will be reviewed with a focus on the major autoimmune disorders, namely, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes mellitus (T1D), Sjögren's syndrome, and autoimmune thyroiditis (AITD). Early age at onset is a worst prognostic factor for some ADs (i.e., SLE and T1D), while for others it does not have a significant influence on the course of disease (i.e., SS) or no unanimous consensus exists (i.e., RA and MS).

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HLA class II polymorphism in Latin American patients with multiple sclerosis

Cited by 41 publications

References 39 publications

Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls

Variants in the IL7RA gene confer susceptibility to multiple sclerosis in Caucasians: evidence based on 9734 cases and 10436 controls

The Autoimmune Tautology: An In Silico Approach

How Does Age at Onset Influence the Outcome of Autoimmune Diseases?

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