HLA class II haplotypes in Mexican systemic lupus erythematosus patients

Cortes, Lizette M.; Baltazar, L.M.; López-Cardona, María Guadalupe; Olivares, Norma; Ramos, César; Salazar, Mario; Sandoval, Lucila; Lorenz, Matthias G.O.; Chakraborty, Ranajit; Paterson, Andrew D.; Rivas, Fernando

doi:10.1016/j.humimm.2004.09.008

Cited by 30 publications

(18 citation statements)

References 35 publications

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“…We identified a total of 393 potentially relevant articles to our search criteria, of which 25 studies examining the association between HLA alleles and SLE are presented in Table . A detailed flow diagram of the study selection process is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis

2014

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Aim: Human leukocyte antigen (HLA)-DRB1 allele polymorphisms have been reported to be associated with systemic lupus erythematosus (SLE) susceptibility, but the results of these previous studies have been inconsistent. The purpose of the present study was to systematically summarize and explore whether specific HLA-DRB1 alleles confer susceptibility or resistance to SLE and lupus nephritis.Methods: This review was guided by the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach. A comprehensive search was made for articles from PubMed, Medline, Elsevier Science, Springer Link and Cochrane Library database. A total of 25 case-control studies on the relationship between gene polymorphism of HLA-DRB l and SLE were performed and data were analyzed and processed using Review Conclusions: The HLA-DR4, DR11, DR14 alleles might be protective factors for SLE and HLA-DR3, DR9, DR15 were potent risk factors. In addition, HLA-DR4 and DR11 alleles might be protective factors for lupus nephritis and DR3 and DR15 suggest a risk role. These results proved that HLA-DR3, DR15, DR4 and DR11 might be identified as predictors for lupus nephritis and SLE.

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Section: Resultsmentioning

confidence: 99%

Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis

2014

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“…Studies in nonwhite populations have shown inconsistent results [40]–[44]. Inherited (and acquired) deficiencies of the early classical complement components, C2, C4A, and C4B, encoded within the class III region, are associated with the development of lupus [45].…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

et al. 2008

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The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases. However, identification of causal variants within the MHC for the majority of these diseases has remained difficult due to the great variability and extensive linkage disequilibrium (LD) that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 from a total of approximately 250 genes have been studied in small cohorts of predominantly European origin. We have performed a review and pooled analysis of the past 30 years of research on the role of the MHC in six genetically complex disease traits – multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), ulcerative colitis (UC), Crohn's disease (CD), and rheumatoid arthritis (RA) – in order to consolidate and evaluate the current literature regarding MHC genetics in these common autoimmune and inflammatory diseases. We corroborate established MHC disease associations and identify predisposing variants that previously have not been appreciated. Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity.

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“…Reports on HLA class II in Mexico have been published (8,14,15,46), but high-resolution HLA class I studies are limited in number and sample size (2,3). On the other hand, studies on segregating HLA haplotypes are considered desirable (45), but only a few of them are known in Latin America (14,23,46).…”

Section: Population Comparisonsmentioning

confidence: 99%

HLA‐A and HLA‐B allele frequencies in a mestizo population from Guadalajara, Mexico, determined by sequence‐based typing

Leal¹,

Mendoza-Carrera

Rivas

et al. 2005

Tissue Antigens

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HLA-A and HLA-B genes were typed by DNA sequencing in a mestizo population from Guadalajara, Jalisco, Mexico. Thirty-seven HLA-A and 51 HLA-B alleles were observed in 103 samples. The common typical Amerindian alleles (>5%) and haplotypes (>or=2.0%) found were A*02010101, *24020101, *310102, B*350101, and *4002, and A*310102-B*4002, A*240201-B*350101, and the typical European alleles were A*010101, *29010101, B*1402, B*180101, and A*020101-B*1402, A*020101-B*510101, and A*3002-B*180101. This reflects the blending of the two main parental populations of mestizos: Amerindian and Iberian. Mexicans were found to be relatively closer to the Portuguese than to Spaniards. This proximity may indicate a larger Portuguese influence in Mexicans than previously considered. Present data contribute to the understanding of the genetic structure in Mexico.

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HLA class II haplotypes in Mexican systemic lupus erythematosus patients

Cited by 30 publications

References 35 publications

Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis

Value of HLA-DR genotype in systemic lupus erythematosus and lupus nephritis: a meta-analysis

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

HLA‐A and HLA‐B allele frequencies in a mestizo population from Guadalajara, Mexico, determined by sequence‐based typing

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