HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population

Krokowski, Marcin; Bodalski, Jerzy; Bratek, Agnieszka; Caillat‐Zucman, Sophie

doi:10.1016/s0198-8859(98)00036-6

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…Its odds ratio was the lowest in the study (OR = 4.90). Our results are similar to data published by Caillat-Zucman et al [7] or Krokowski et al [8]. The only difference is in the frequency of the known risk allele DQB1*0201.…”

Section: Discussionsupporting

confidence: 92%

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Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion

et al. 2004

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Section: Discussionsupporting

confidence: 92%

“…The complicated analysis of HLA genotypes is simplified by strong linkage disequilibrium between HLA DRB1, DQA1 and DQB1 loci. Childhood T1DM is characterized by an abrupt onset and ketosis and is associated with HLA DRB1*04-DQA1*0301-DQB1*0302, and a high frequency of insulin and thyrosin-phosphatase autoantibodies [7,8].…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion

et al. 2004

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“…We sought to characterize the contribution of the DRB1*04 subtypes to HLA‐encoded type 1 DM susceptibility (2, 3, 19–22). While it is generally agreed that DRB1*0403 acts as a dominantly protective factor (3, 19, 23, 24), the effect of other DRB1*04 subtypes varies substantially among populations, including Central and Eastern Europe (19, 25, 26). We decided to analyze the DRB1*04 alleles carried on the DQA1*03‐DQB1*0302 haplotypes; this approach has been used in several major studies (2, 26).…”

Section: Discussionmentioning

confidence: 99%

HLA class II genetic association of type 1 diabetes mellitus in Czech children

et al. 2001

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To examine human leukocyte antigen (HLA) class II association of type 1 diabetes mellitus (DM) in Czech children, we performed a case-control study of 261 patients diagnosed before the age of 15 and 289 non-diabetic control children. Complete HLA-DQA1, DQB1 genotyping and DRB1*04 subtyping were carried out by polymerase chain reactions with sequence-specific primers. The effect of the DRB1*04 subtypes was studied in DRB1*04 alleles carried on DQB1*0302-DQA1*03 haplotypes. The risk was statistically evaluated by testing 2 x 2 tables, considering corrected p-values < 0.05 significant. The DQB1*0302 (odds ratio, OR = 9.0), DQB1*0201 (OR = 3.4) and DQA1*03 (OR = 7.5) alleles were significantly associated with diabetes risk, while the DQB1*0602 (OR = 0.02), DQB1*0301 (OR = 0.08), DQB1*0503 (OR = 0.13), DQB1*0603 (OR = 0.20), DQA1*01 (OR = 0.28) and DQA1*02 (OR = 0.26) alleles were significantly protective. Of the DQA1-DQB1 genotypes, we point out the extremely high risk of OR = 116 conferred by HLA-DQA1*05-DQB1*0201/DQA1*03-DQB1*0302. Among DRB1*04 subtypes, DRB1*0403 was significantly protective (OR = 0.05, CI 95% 0.01-0.45). Since none of the remaining DRB1*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify type 1 diabetes risk generally in European populations.

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“…Type 1 diabetes mellitus (T1DM) is characterized by an abrupt onset and ketosis. It is associated with HLA DRB1*04-DQA1*0301-DQB1*0302, and a high frequency of insulin (IAA) and thyrosin-phosphatase (IA-2) autoantibodies [4,5]. The term latent autoimmune diabetes in adults (LADA) was introduced to define adult diabetic patients initially noninsulin-requiring but with immune markers of type 1 diabetes that, in most cases, progress to insulin dependency [6].…”

Section: Introductionmentioning

confidence: 99%

Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults

Novota¹,

Kološtová²,

Pintérová³

et al. 2005

Immunology Letters

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HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population

Cited by 24 publications

References 24 publications

Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion

Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion

HLA class II genetic association of type 1 diabetes mellitus in Czech children

Interleukin IL-18 gene promoter polymorphisms in adult patients with type 1 diabetes mellitus and latent autoimmune diabetes in adults

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