HLA Class II Alleles and Leprosy(Hansen's Disease) Classified by WHO-MDT Criteria.

覚, 上甲; 二郎, 沼賀; 寛次郎, 増田; まさ子, 並里; 平生, 前田

doi:10.5025/hansen.65.121

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…11 Molecular HLA typing has allowed DR2 to be refined into HLA-DRB1 subtypes. DRB1*1501 has been associated with lepromatous leprosy 26,30 whereas DRB1*1502 has been associated with tuberculoid leprosy. 45 The *1501 and *1502 alleles differ from each other by a single amino acid at codon 86.…”

Section: Class II Regionmentioning

confidence: 99%

“…DQ alleles, especially DQw1 have been shown to be associated with tuberculoid leprosy in India, 26,27 Korea, 19 Thailand 28 and Japan, 29 and with lepromatous leprosy in India 15 and Japan. 18,30 DQw1 was also implicated in a meta-analysis of pooled association studies 31 and in a Venezuelan lepromatous family study 10 whereas in Shaw's recent Brazilian family study significant evidence for linkage and association to tuberculoid leprosy and possibly leprosy per se was found with DQB1, DQA1 and DRB1 variants. 32 Unusual DQ restricted antigen-specific CD8 cells that predominantly produce IL4 were proposed to act as suppressor cells in lepromatous patients; 33 however, this does not explain the association with tuberculoid leprosy.…”

Section: Class II Regionmentioning

confidence: 99%

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Genetics of susceptibility to leprosy

2002

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The ancient disease of leprosy can cause severe disability and disfigurement and is still a major health concern in many parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy sufferers. The outcome of infection is in part due to host genes that influence control of the initial infection and the host's immune response to that infection. Identification of the host genes that influence host susceptibility/resistance will enable a greater understanding of disease pathogenesis. In turn, this should facilitate development of more effective therapeutics and vaccines. So far at least a dozen genes have been implicated in leprosy susceptibility and a genome-wide linkage study has lead to the identification of at least one positional candidate. These findings are reviewed here.

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Section: Class II Regionmentioning

confidence: 99%

Section: Class II Regionmentioning

confidence: 99%

Genetics of susceptibility to leprosy

2002

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“…[ 24 ] reported a decreased frequency of HLA-DRB1*0701 in LL and BL patients compared to TT patients and healthy controls in a population from Northern India, and they assigned this allele a protective effect against multibacillary (MB) forms. HLA-DRB1*1501 and HLA-DQB1*0602 were associated with susceptibility in MB patients in Japan, and no allele was associated with protection in this population [ 34 ]. Silva et al .…”

Section: Discussionmentioning

confidence: 99%

“…Studies of HLA class I (HLA-A, HLA-B, and HLA-C) have been conducted in various populations [ 13 - 18 ]. For HLA class II (HLA-DR and DQ), the most consistent findings are that HLA-DR2 (subtypes HLA-DRB1*15 and HLA-DRB1*16) and HLA-DQ1 (subtypes HLA-DQB1*05 and HLA-DQB1*06) are associated with the TT and LL clinical forms, respectively [ 19 - 27 ], and are also associated with leprosy per se [ 28 - 34 ]. To confirm these previous findings, 2 genome-wide linkage analyses was done and identified chromosome 6p21 as a major leprosy susceptibility locus in the HLA gene cluster [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil

et al. 2015

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BackgroundEvidence suggests that human leukocyte antigen (HLA) alleles influence the host immune response against Mycobacterium leprae. However, the association between HLA alleles and borderline (B) leprosy has not been studied. The aim of this study was to determine whether HLA class I and II molecules are associated with susceptibility or resistance to B leprosy including borderline-tuberculoid (BT), borderline-borderline (BB), and borderline-lepromatous (BL).MethodsDNA was obtained by the salting-out technique from the blood samples of 202 patients with B leprosy and 478 control subjects. HLA class I (A*, B*, and C* loci) and class II (DRB1* and DQB1* loci) genotypes were determined by polymerase chain reaction amplification and reverse hybridization with sequence-specific oligonucleotide probes and sequence-specific primers.ResultsThe case-controlled analysis results showed a significant association between B leprosy and HLA-C*05 (5.94% vs. 14.02%; p = 0.002, OR = 0.38, 95% CI = 0.20–0.73, pc = 0.032) and HLA-DRB1*07 (16.34% vs. 26.77%; p = 0.003, OR = 0.53, 95% CI = 0.3–0.8, pc = 0.039). A protective association was observed between BL leprosy and HLA-DQB1*02 (18.18% vs. 39.53%; p = 0.005, OR = 0.34, 95% CI = 0.15–0.75, pc = 0.025). In reactional patients, a significant association was observed between HLA-B*15 (28.72% vs. 12.76%; p = 0.011, OR = 2.75, 95% CI = 1.30–5.85, pc = 0.352) and predisposition to reversal reaction. Haplotype analysis showed that A*02-B*07-C*07-DRB1*15-DQB1*06 (2.97% vs. 1.04%; p = 0.015) and A*02-B*40-C*03-DRB1*13-DQB1*06 (1.73% vs. 0.10%; p = 0.0011) were associated with susceptibility to the B form. The presence of the HLA-DRB1*02 or HLA-DRB1*03/HLA-DQB1*01 haplotypes in B patients (22.05% vs. 33.0%; p = 0.005) suggested the involvement of these haplotypes in this clinical form of the disease.ConclusionsThe results indicate the involvement of HLA class I and class II molecules in B leprosy and reversal reactions; it also suggest a role for HLA in polarization of the disease in this group of patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-015-0751-0) contains supplementary material, which is available to authorized users.

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“…150 DQ alleles, especially DQw1 have been shown to be associated with TT in India, 148,123 Korea, 141 Thailand, 149 and Japan. 151 Importantly, HLA DQ1 is in strong linkage disequilibrium with HLA-DR2 in most populations and it has usually been difficult to discern whether the primary association is with the DR or the DQ variant.…”

Section: -133mentioning

confidence: 99%

Major histocompatibility complex and its importance towards controlling infection

Longjam

Das

2017

Asian J Med Sci

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It is well documented that infectious pathogen burden and infected cell mass determine the clinical severity of infectious diseases, however, the ability of the host to recognize and process antigens to produce antibodies or the cellular immune response during infection could be under genetic control. The Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) system is the most intensively studied of all genetic systems because of its influence to many important traits, including resistance to infectious diseases, autoimmunity and immunological self or nonself compatibility. This is understandable in the light of the evolutionary pressure so that we are equipped to face the multitude of infectious challenges. Infectious diseases are a major selective pressure;and genes involved in the immune response are the most numerous and diverse in the human genome; reflecting the evolutionary advantages of a diverse immunological response to a wide range of infectious pathogens.Asian Journal of Medical Sciences Vol.8(2) 2017 1-13

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HLA Class II Alleles and Leprosy(Hansen's Disease) Classified by WHO-MDT Criteria.

Cited by 10 publications

References 7 publications

Genetics of susceptibility to leprosy

Genetics of susceptibility to leprosy

Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil

Major histocompatibility complex and its importance towards controlling infection

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