HLA class I genotyping including HLA‐B*51 allele typing in the Iranian patients with Behçet’s disease

Mizuki, Nobuhisa; Ôta, Masao; Katsuyama, Yoshihiko; Yabuki, Kazuro; Ando, Hitoshi; Yoshida, Masao; Onari, Katsuhiro; Nikbin, Behrouz; Davatchi, Fereydoun; Chams, Hormoz; Ghaderi, Abbas; Ohno, Shigeaki; Inoko, Hidetoshi

doi:10.1034/j.1399-0039.2001.057005457.x

Cited by 46 publications

(37 citation statements)

References 11 publications

(12 reference statements)

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“…Members of this group share the amino acid alanine at position 26, which contributes to the structure of peptide-binding pocket B and determines the motif of bound peptides [16]. In this study, we found three HLA-B alleles different from others studies in which the HLA-B * 51 allele has been associated consistently in Turkish, Korean, Greek, Japanese, Israel Arabs, Iranian, Italian, and Moroccan patients [17][18][19][20][21][22][23][24]. These alleles, in Mexicans, might be the equivalent of HLA-B51 found in the above mentioned populations.…”

Section: Discussioncontrasting

confidence: 46%

Class I and class II MHC polymorphisms in Mexican patients with Behçet’s disease

et al. 2004

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Section: Discussioncontrasting

confidence: 46%

Class I and class II MHC polymorphisms in Mexican patients with Behçet’s disease

et al. 2004

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“…While HLA-A*26 has been reported to be associated with BD in Taiwan and in Greece [39,40], no significant associations have been found between HLA-A alleles and BD in studies conducted in Palestine, Jordan, Iran, Ireland, Italy, or Turkey [29,[41][42][43][44]. However, it was clearly demonstrated that HLA-A*26 is a primary susceptibility gene of BD in the Japanese GWAS [11].…”

Section: Hla-a Regionmentioning

confidence: 54%

Behçet’s disease and genes within the major histocompatibility complex region

Song

Kang

2011

Mod Rheumatol

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The role of genetic background in the development of Behçet's disease (BD) is best reflected by the strong association between HLA-B*51 and BD that has been demonstrated across various ethnic groups. The contributions made by other HLA or non-HLA genes to disease susceptibility have been suggested by the results of a number of gene association studies, although the true associations between the genes located within the major histocompatibility complex (MHC) region and BD have often been doubted due to the possibility of linkage disequilibrium of those genes with HLA-B*51. The presence of a true susceptibility gene in the vicinity of HLA-B*51 has also been extensively investigated because of the limited evidence that directly relates HLA-B*51 to the pathogenesis of BD. However, recent genome-wide association studies have confirmed that HLA-B*51 is primarily associated with BD and that there are multiple susceptibility loci other than HLA-B*51. In this review, we discuss BD-associated genes within the MHC region and their biological roles in the pathogenesis of BD.

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“…HLA-B*5101 allele expression is associated with Behçet disease [31,32], a multisystemic inflammatory disorder possibly of autoimmune nature [33,34]. The linkage is very suggestive of involvement of peptide presentation function, since Behçet disease is not associated with HLA-B*5201, which differs by only two amino acids located in the pocket B of the peptidebinding groove [34].…”

Section: Discussionmentioning

confidence: 84%

Sampling of Major Histocompatibility Complex Class I-Associated Peptidome Suggests Relatively Looser Global Association of HLA-B*5101 With Peptides

2006

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SummaryWe have analyzed peptides associated with six human MHC class I allomorphs expressed by the U937 cell line. Peptides were isolated by mild acid elution or by MHC class I immunoprecipitation using W6/32 monoclonal antibody. A total of 85 peptides were sequenced by mass spectrometry and their putative binding alleles were assigned using bioinformatic tools. Only three peptides isolated by the two approaches were identical, suggesting that the approaches may yield distinct, partially overlapping peptide populations. Mild acid treatment-derived peptides had overall characteristics suggestive of relatively lower affinity of binding for MHC class I. Interestingly, a large proportion of putative HLA-B*5101-binding peptides was found among the mild-acid treatment eluted peptides, and to a lesser degree in the affinity-purified peptide pool. These results suggest that HLA-B*5101 may bind a potentially large pool of peptides with relatively lower affinity. We suggest that lower affinity of peptide binding may be the basis for inefficient tolerance to HLA-B*5101-binding selfpeptides, a predisposing factor for the development of Behçet disease.

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HLA class I genotyping including HLA‐B*51 allele typing in the Iranian patients with Behçet’s disease

Cited by 46 publications

References 11 publications

Class I and class II MHC polymorphisms in Mexican patients with Behçet’s disease

Class I and class II MHC polymorphisms in Mexican patients with Behçet’s disease

Behçet’s disease and genes within the major histocompatibility complex region

Sampling of Major Histocompatibility Complex Class I-Associated Peptidome Suggests Relatively Looser Global Association of HLA-B*5101 With Peptides

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