HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese

Mabuchi, Tomotaka; Ota, Tami; Manabe, Yasuaki; Ikoma, Norihiro; Ozawa, A.; Terada, Tadashi; Ikeda, Shigaku; Inoko, Hidetoshi; Oka, Akira

doi:10.1016/j.jdermsci.2016.08.154

Cited by 13 publications

(21 citation statements)

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“…However, no SNPs in the exons of HLA‐A , HLA‐B , or HLA‐C were found to be in high linkage disequilibrium with rs4947296. An SNP located between the C6orf15 and HCG22 genes was found to be independently correlated with lupus nephritis, and the 6p21.3 region containing C6orf15 was reported to be associated with psoriasis vulgaris …”

Section: Discussionmentioning

confidence: 99%

Genetic study of early‐onset Graves’ disease in the Chinese Han population

Yuan

Liu

et al. 2017

Clinical Genetics

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Graves' disease (GD) is a complex autoimmune disorder in which genetic and environmental factors are both involved in the pathogenesis. Early-onset patients have a shorter exposure time to environmental factors and are, therefore, good models to help understand the genetic architecture of GD. Based on previous studies of early-onset GD, 11 single nucleotide polymorphisms (SNPs) and their related SNPs (R 2 > .6), SNPs located within a AE1-Mb region of the FOXP3 gene, and 20 validated GD-risk SNPs were selected and screened for genotyping in 3735 GD and 4893 control patients to investigate whether early-onset GD is a subtype of GD with distinct susceptibility genes. Ultimately, we did not confirm the reported genetic markers of early-onset GD in our Chinese Han population but found that a GD-risk SNP located in the human leukocyte antigen class I region-rs4947296-was more strongly correlated with earlyonset GD than non-early-onset GD. In addition, heterogeneity analysis of GD patients suggests that it may be more reasonable to define early-onset GD as an onset age ≤20 years.

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Section: Discussionmentioning

confidence: 99%

Genetic study of early‐onset Graves’ disease in the Chinese Han population

Yuan

Liu

et al. 2017

Clinical Genetics

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“…Prawidłowość tę powiązano w pracy Mabuchi i wsp. z oddziaływa-niem czynników środowiskowych dotyczących głównie mężczyzn, takich jak palenie tytoniu, spożycie alkoholu i sposób odżywiania [24]. Średni wiek pacjentów przy rozpoznaniu choroby wynosił 36,24 ±9,47 roku.…”

Section: Omówienieunclassified

“…Dane z literatury światowej wskazują, że łuszczyca risk factors which are common in men such as smoking, alcohol intake and diet [24]. The mean age of presentation of the patients was 36.24 ±9.47.…”

Section: Omówieniementioning

confidence: 99%

Clinical evaluation of omega-3 fatty acids in psoriasis

Adil¹,

Singh²,

Maheshwari³

2017

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Introduction. Omega-3 fatty acids are largely derived from fish oils and are known to decrease inflammation. There have been a few small studies showing the beneficial effect of omega-3 fatty acids in psoriasis.Objective. To evaluate the efficacy of omega-3 fatty acids in conjunction with emollients in patients with mild to moderate chronic plaque psoriasis. Materials and methods.A total of 200 clinically diagnosed cases of chronic plaque psoriasis with less than 10% of body surface area involvement were recruited and divided into group A and group B. Group A was given 1,800 mg daily of omega-3 fatty acids in three divided oral doses and topical paraffin over the lesions. Group B was prescribed only topical paraffin. At the end of 12 weeks, treatment response was assessed by means of Psoriasis Area Severity Index (PASI), and by its components including area involved, erythema, induration and desquamation scores.Results. The mean PASI score changed from 7.44 to 3.96 in group A, and from 7.24 to 5.19 in group B. There was a statistically significant difference in PASI, erythema, induration, desquamation scores and area involved between the two groups after 12 weeks. Forty four (46.3%) patients in group A and 13 (13.9%) patients in group B achieved a 50% or more reduction in PASI scores.Conclusions. Omega-3 fatty acids in conjunction with topical emollients appear to reduce the severity of psoriasis with no major side effects. The combination can be a useful adjunct to other psoriasis treatments. STRESZCZENIEWprowadzenie. Kwasy omega-3 są pozyskiwane głównie z olejów rybnych. Jedną z potwierdzonych właściwości tych kwasów jest hamowanie stanu zapalnego. Przeprowadzono dotychczas kilka niewielkich badań, w których stwierdzono skuteczność kwasów tłuszczowych omega-3 w leczeniu łuszczycy.Cel pracy. Ocena skuteczności działania kwasów tłuszczowych omega-3 w skojarzeniu z emolientami w leczeniu pacjentów z łuszczycą plackowatą łagodną i umiarkowaną. Original article/Praca oryginalnaClinical evaluation of omega-3 fatty acids in psoriasis Kliniczna ocena działania kwasów tłuszczowych omega-3 w leczeniu łuszczycy Materiał i metodyka. Do badania włączono 200 pacjentów z klinicznie rozpoznaną łuszczycą obejmującą poniżej 10% powierzchni skóry. Uczestników podzielono na dwie grupy: A i B. Pacjenci z grupy A przyjmowali doustnie 1800 mg kwasów tłuszczowych omega-3 dziennie w trzech dawkach podzielonych oraz stosowali parafinę miejscowo na zmiany skórne. Pacjenci z grupy B przyjmowali wyłącznie parafinę. Po upływie 12 tygodni odpowiedź na leczenie oceniono przy wykorzystaniu wskaźnika PASI (Psoriasis Area Severity Index), na podstawie powierzchni skóry objętej zmianami oraz stopnia nasilenia rumienia, nacieku i łuski. Wyniki. Średni wskaźnik PASI zmniejszył się z 7,44 do 3,96 w grupie A oraz z 7,24 do 5,19 w grupie B. Różnica między grupami pod względem wskaźnika PASI, nasilenia rumienia, nacieku i łuski oraz powierzchni zmian skórnych po upływie 12 tygodni była istotna statystycznie. U 44 (46,3%) pacjentów z grupy A i ...

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“…Recent genome‐wide association studies have identified numerous risk‐associated variants within 44 susceptibility loci for psoriasis, including HLA‐C*06:02 , LCE3D , IL23R and CARD14 . HLA‐C*12:02 may be a susceptibility locus for late‐onset psoriasis in the Japanese population . These susceptibility genes are predominantly related to the innate and adaptive immune system and skin barrier function .…”

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confidence: 99%

Psoriasis: Behind the scenes

Furue

Kadono

2016

The Journal of Dermatology

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Psoriasis is a chronic inflammatory skin disease characterized by a significant deterioration in the quality of life of affected individuals. Notably, psoriasis is significantly associated with cardiovascular and metabolic syndrome and other autoimmune disorders. Recent progress in biologic therapies has revealed the fundamental role of tumor necrosis factor-a, interleukin (IL)-23 and the IL-17A axis together with aberrant overproduction of epidermal IL-36c in the pathogenesis of psoriasis. This review provides an update on the clinical, pathological and therapeutic advancements involving psoriasis.

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HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese

Cited by 13 publications

References 0 publications

Genetic study of early‐onset Graves’ disease in the Chinese Han population

Genetic study of early‐onset Graves’ disease in the Chinese Han population

Clinical evaluation of omega-3 fatty acids in psoriasis

Psoriasis: Behind the scenes

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