Hla-Bw35 and B5 in Japanese Patients With Graves' Disease

Kawa, A.; Nakamura, Shigetaka; Nakazawa, Michio; Sakaguchi, S; Kawabata, Takeko; Maeda, Yoshizane; Kanehisa, Takuya

doi:10.1530/acta.0.0860754

Cited by 48 publications

(11 citation statements)

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“…There is strong familial tendency as well as ethnic HLA association, namely A2B46DR9 in Chinese, B35 and B46 in Japanese and A1B8DR3 in Caucasians. 4,[8][9][10][11] We showed that post-SCT AITD in Chinese has the same HLA and donor sex associations as in de novo AITD. Three factors may have triggered such HLA-related AITD: namely, inherent patient susceptibility, the effect of conditioning chemotherapy and radiotherapy, and the graftversus-host effect of the infused lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Lie

Kung

et al. 2005

Bone Marrow Transplant

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Summary:Autoimmune thyroid disease (AITD) may occur in patients after hematopoietic stem cell transplantation (HSCT). In all, 10 cases of AITD (seven allogeneic and three autologous HSCT) were diagnosed among 721 HSCT recipients, including two patients with sequential hyper-and hypothyroidism. The 5-year actuarial rates for AITD after allogeneic and autologous HSCT were 2.9 and 4%, respectively. Significant risk factors included HSCT for chronic myeloid leukemia, the HLA B46 and DR9 loci and the A2B46DR9 haplotype, while female donors showed trend to significance. On multivariate analysis, only female donors and HLA DR9 remained significant. For autologous HSCT, the associations with HLA B46 and DR9 were also significant. Only three donors had a family history of AITD. A review of other reported cases confirmed the predominance of female donors, although the other associations including graftversus-host disease, familial AITD and other autoimmune phenomena might be related to reporting bias. Since the actuarial incidence of AITD from female donors with predisposing HLA alleles may be over 30%, susceptible recipients should be carefully monitored. Owing to the small number of reported cases and different HLA associations with AITD in different populations, our observations await confirmatory data from other registries.

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Section: Discussionmentioning

confidence: 99%

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Lie

Kung

et al. 2005

Bone Marrow Transplant

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“…Inoue et al reported a case with a rare combination of autoimmune disorders, including Graves' disease, AIH and mixed connective tissue disease, that might be caused by each of the sensitive HLA antigens of these disorders [11]. Our patient had positive A2 and B35, which has been related to Graves' disease in Japanese [12,13], and also had DR4, which has been correlated with type 1 DM and AIH in Japanese [14][15][16]. Thus, in our case, the possibility exists that these three disorders might be induced by the combination of these HLA antigens.…”

Section: Discussionmentioning

confidence: 60%

A Case of Polyglandular Autoimmune Syndrome Type III Complicated with Autoimmune Hepatitis

et al. 2006

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Abstract.A 58-year-old woman complaining of finger tremor was referred to our hospital. The diagnosis of Graves' disease was made based on increased free triiodothyronine (18.88 pg/ml) and free thyroxine (7.47 ng/dl), low TSH (<0.005 µIU/ml) and increased TSH receptor binding antibody activity (70.9%). Serum level of AST (62 U/l) and ALT (93 U/l) were increased and liver biopsy revealed linkage of adjacent portal areas by lymphoplasmacytic infiltrates and fibrosis with piecemeal necrosis. Although antinuclear antibody was negative, these findings indicated that she had autoimmune hepatitis (AIH) according to the criteria of the International Autoimmune Hepatitis Scoring System. Slowly progressive type 1 diabetes mellitus (DM) was confirmed by a diabetic response pattern due to 75 g-oral glucose tolerance test, and seropositivity towards anti-glutamic acid decarboxylase (725 U/ml) and islet cell (80 JDF Units) antibodies. This case exhibited an extremely rare combination of three different autoimmune diseases, including Graves' disease, slowly progressive type 1 DM and AIH, and had no known sensitive human leukocyte antigen (HLA) typing or haplotype for these disorders. Alhough it is common for patients with Graves' disease to exhibit abnormal liver function, it is important to make an accurate diagnosis of AIH because of this life-threatening disorder.

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“…In addition, HLA-DW3/ DR3 is known to be in strong linkage disequilibrium with HLA-B8 (Thorsby & Piazza, 1976). In the Japanese where the HLA-B8 and -DW3/ DR3 are virtually absent, Graves' disease was found to be associated not with HLA-B8, but with BW35 Kawa et al, 1977;Nakao et al, 1978). Moreover, in the Japanese the association with HLA-BW35 seems to be secondary to an increase in an HLA-D determinant (HO) which is different from HLA-DW3 (Sasazuki et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the definite association between Graves' disease and HLA (Grumet et al, 1975;Farid et al, 1976;Kawa et al, 1977), no such relation has been shown for Hashimoto's thyroiditis (Bode et al, 1973;Farid et al, 1975Farid et al, , 1976van Rood et al, 1975;Mayr et al, 1976, Konishi et al, 1977. However, most studies of Japanese patients with these diseases only concern the antigens of the A, B and C segregant series.…”

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confidence: 98%

HLA-DR antigens in japanese with hashimoto's thyroiditis and graves' disease.

Azuma¹,

Sakurami

Ueno

et al. 1982

Endocrinol Japon

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HLA-A, -B, -C and -DR specificities were determined to study the association of HLA in 49 unrelated patients with Hashimoto's thyroiditis and 51 patients with Graves' disease. The results were compared with 144 control subjects from the Japanese population at large. Much less HLA-DR2 was found in the patients with Hashimoto's thyroiditis than in the normal controls. It was present in 16% of the thyroiditis patients compared to 39% in the controls. Also the frequency of HLA-DR1 was less in the patients with Graves' disease (0%) than in the controls (15%). No positive association was found for any HLA-antigens in the two diseases.

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Hla-Bw35 and B5 in Japanese Patients With Graves' Disease

Cited by 48 publications

References 0 publications

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation

A Case of Polyglandular Autoimmune Syndrome Type III Complicated with Autoimmune Hepatitis

HLA-DR antigens in japanese with hashimoto's thyroiditis and graves' disease.

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