HLA-B Locus in Japanese Patients with Anti-Epileptics and Allopurinol-Related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Kaniwa, Nahoko; Saito, Yoshiro; Aihara, Michiko; Matsunaga, Kayoko; Tohkin, Masahiro; Kurose, Kouichi; Sawada, Jun‐ichi; Furuya, Hirokazu; Takahashi, Yukitoshi; Muramatsu, Masaaki; Kinoshita, Shigeru; Abe, Mihoko; Ikeda, Hiroko; Kashiwagi, Mariko; Song, Yingliang; Ueta, Mayumi; Sotozono, Chie; Ikezawa, Zenrō; Hasegawa, Ryuichi

doi:10.2217/14622416.9.11.1617

Cited by 354 publications

(272 citation statements)

References 17 publications

Supporting

Mentioning

257

Contrasting

Unclassified

Order By: Relevance

“…20 We have reported earlier that four out of 10 Japanese patients (40%) with allopurinol-induced SJS ⁄ TEN carried HLA-B*5801. 20 A moderate but statistically significant association (P < 10…”

Section: Association Between Hla-b*5801 and Allopurinol-induced Cutanmentioning

confidence: 96%

“…[20][21][22][23] Ueta et al reported a case-control study on the relationships between HLA class I and II genetic polymorphisms with severe ocular complications using 71 Japanese drug-unspecified SJS ⁄ TEN patients and 101 Japanese controls. No HLA-B*1502 carriers were detected in cases or controls.…”

Section: Allele Associations With Carbamazepine-induced Sjs ⁄ Ten Inmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacogenetics of cutaneous adverse drug reactions

Aihara

2011

The Journal of Dermatology

Self Cite

View full text Add to dashboard Cite

Drug-induced hypersensitivity reactions are of major medical concern because they are associated with high morbidity and high mortality. In addition, individual patients' reactions are impossible to predict in each patient. In the field of severe cutaneous adverse drug reactions (cutaneous ADR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug-induced hypersensitivity syndrome (DHIS) or drug rash with eosinophilia and systemic symptoms (DRESS), major advances have recently been gained through studies of an association between HLA alleles and drug hypersensitivity induced by specific drugs. The results of these pharmacogenomic studies allow prediction of the risk of adverse reactions in patients treated with certain drugs, including carbamazepine and other aromatic antiepileptic drugs, allopurinol and abacavir. However, different ethnic populations show variations in the genetic associations. A strong association between carbamazepine-induced SJS ⁄ TEN and HLA-B*1502 has been found in Southeast Asian patients but not in Caucasian and Japanese patients. Moderate associations between aromatic amine anticonvulsants and other HLA alleles have been proposed in Japanese patients. In contrast, HLA-B*5801 was found to be associated with allopurinol-induced cutaneous ADR, including SJS ⁄ TEN and DIHS ⁄ DRESS, in Caucasian and Asian patients, including the Japanese. These differences may, at least in part, be due to the differences in allele frequency in different ethnic populations. This article reviews the progress in pharmacogenomics, associated mainly with carbamazepine and allopurinol in different ethnic populations. Pharmacogenetic screening based on associations between adverse reactions and specific HLA alleles helps to avoid serious conditions associated with drug hypersensitivity.

show abstract

Section: Association Between Hla-b*5801 and Allopurinol-induced Cutanmentioning

confidence: 96%

Section: Allele Associations With Carbamazepine-induced Sjs ⁄ Ten Inmentioning

confidence: 99%

Pharmacogenetics of cutaneous adverse drug reactions

Aihara

2011

The Journal of Dermatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In line with these results, other studies linked variants in HLA genes on chromosome 6 with autoimmune diseases [62,63]. Additionally, several HLA-B alleles were associated with small molecule drug allergy and adverse reactions [64][65][66][67][68][69]. Specifically, HLA-DRB1*07 : 01 allele was associated with elevated levels of serum alanine transferase during ximelagatrn and lapatinib treatment through a drug-induced adaptative immune response [70,71].…”

Section: Pharmacogeneticsmentioning

confidence: 60%

Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene

Lopez-Santillan

Iparraguirre

Martín-Guerrero

et al. 2017

Drug Metabolism and Personalized Therapy

View full text Add to dashboard Cite

Acute lymphoblastic leukemia (ALL) is a major pediatric cancer in developed countries. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, hypersensitivity reactions are common. In those cases, discontinuation of treatment is usually needed and anti-asparaginase antibody production may also attenuate asparaginase activity, compromising its antileukemic effect. Till now, six pharmacogenetic studies have been performed in order to elucidate possible genetic predisposition for inter-individual differences in asparaginase hypersensitivity. In this review we have summarized the results of those studies which describe the involvement of four different genes, being polymorphisms in the glutamate receptor, ionotropic, AMPA 1 (GRIA1) the most frequently associated with asparaginase hypersensitivity. We also point to new approaches focusing on epigenetics that could be interesting for consideration in the near future.

show abstract

“…These findings were replicated in an extended cohort of subjects of Chinese descent originating from separated geographic areas of China, Taiwan, and the United States [61]. This association with carbamazepine-induced SJS/TEN, however, was not found in individuals with European [62] and Japanese ancestries [63], respectively, and therefore the allele appears relevant in the context of ethnicity. The role of these HLA alleles in the pathogenesis of SCAR is unclear.…”

Section: Genetic Susceptibilitymentioning

confidence: 69%

“…In contrast, the allele frequency of HLA-A*3101 is 2-5% in Northern Europeans [70] and the sample size required to demonstrate an association in a sufficiently powered study is less than that for the HLA-B*1502 allele. The HLA-B*5801 allele, in contrast to HLA-B*1502 is more evenly distributed among different racial groups [59] and hence, associations, albeit weaker, have been demonstrated in other ethnic groups such as the Southern Japanese [63] and in whites (OR 80 ) [68].…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

Severe Cutaneous Adverse Reactions

Fernando¹

2013

Skin Biopsy - Diagnosis and Treatment

View full text Add to dashboard Cite

HLA-B Locus in Japanese Patients with Anti-Epileptics and Allopurinol-Related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Abstract: While HLA-B1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN, HLA-B5801 was significantly associated with allopurinol-related SJS/TEN in Japanese.

Cited by 354 publications

References 17 publications

Pharmacogenetics of cutaneous adverse drug reactions

Pharmacogenetics of cutaneous adverse drug reactions

Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene

Severe Cutaneous Adverse Reactions

Contact Info

Product

Resources

About

HLA-B Locus in Japanese Patients with Anti-Epileptics and Allopurinol-Related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Abstract: While HLA-B*1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN, HLA-B*5801 was significantly associated with allopurinol-related SJS/TEN in Japanese.

Cited by 354 publications

References 17 publications

Pharmacogenetics of cutaneous adverse drug reactions

Pharmacogenetics of cutaneous adverse drug reactions

Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene

Severe Cutaneous Adverse Reactions

Contact Info

Product

Resources

About

Abstract: While HLA-B1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN, HLA-B5801 was significantly associated with allopurinol-related SJS/TEN in Japanese.