HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions

Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population

“…Among the severe cADRs, HLA-B*57:01 and HLA-DRB1*07:01 were noted to be significantly higher in CBZ-induced SJS/TEN, and HLA-B*51:01, in cases with DRESS caused by PHT, albeit with wide confidence intervals due to the small number of cases. HLA-B*57:01 was also reported recently in an Indian patient who developed urticaria with angioedema followed by acute generalized exanthematous pustulosis (AGEP) due to PHT and CBZ respectively [19]. However, HLA-B*57:01 and B*51:01 are not associated with CBZ or PHT-induced SJS, or MPE in European, Thai or Han Chinese populations [10,20,9,21].…”

Acute generalized exanthematous pustulosis induced by hydroxychloroquine associated with human leukocyte antigen-B51 (HLA-B51), DR1101,04, DQ03,05, and for the first time in the literature with HLA-B15

“…Furthermore the HLA-B15 positivity reported is an interesting finding because HLA-B15 is rare in Caucasians-carrier frequency <1%. After review of the literature the reported case seems to be the first case of confirmed AGEP in a Caucasian associated with HLA-B51, HLA-DR1101,04, HLA-DQ03,05 and with HLA-B15, an HLA-B allele, which although rare in Caucasians, is related-such as HLA-B5701, HLA-B5801 (carbamazepine induced AGEP) 5 to cutaneous adverse drug reactions in Asian populations. Informed consent was obtained.…”