HLA-B*27 – Frequency of clinical signs in Brazilian patients with spondyloarthritis

Toledo, Ricardo Acayaba de; Toledo, Roberto Acayaba de; Camargo, U.; Camargo, Ana Vitória da Silveira; Xavier, Denise Haddad; Batista, M. F.; Carneiro, O; Robles, João Antônio de Camargos Pinto; Mattos, Cinara Cássia Brandão de; Júnior, Octávio Ricci; Mattos, Luiz Carlos de

doi:10.1016/j.bgm.2014.11.002

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…For controls, the HLA-B∗27 frequency was 6.59% and HLA-B∗27:05 was 2.28%, according to what is expected for the Brazilian population ( http://www.allelefrequencies.net/ ). The HLA-B∗27 frequency is lower in SpA in populations with a higher degree of heterogeneity, such as in Latin America, and for AS it was found in 50% to 70% of Brazilian and Ibero-American patients [ 66 – 68 ].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis

Neves

Visentainer

Reis

et al. 2020

International Journal of Inflammation

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Spondyloarthritis (SpA) is an inflammatory rheumatic disease related to low bone mineral density. Because vitamin D plays an important role in bone metabolism and immune system modulation, the aim of this study was to evaluate the influence of polymorphisms in vitamin D receptor genes (VDR) in the development of SpA. In this case–control study, a total of 244 patients with SpA and 197 individuals with no SpA were included. Among the patients, 174 had ankylosing spondylitis (AS) and 66 had psoriatic arthritis (PsA). Genotyping of FokI (rs2228570 C > T), BsmI (rs1544410 C > T), ApaI (rs7975232 A > C), and TaqI (rs731236 T > C) was performed using PCR-RFLP, while genotyping of HLA-B ∗ 27 was performed using PCR-SSP. Serum levels for hydroxy (OH) vitamin D and the clinical activity index of the disease (BASDAI) were also evaluated. SNPStats and OpenEpi software were used for statistical analysis. The ApaI a allele and ApaI a/a genotype were less frequent in PsA compared with controls. The ApaI a/a genotype was associated with a protecting factor for PsA in females, and ApaI A/a was associated with a protecting factor for the disease in HLA-B ∗ 27 positive patients. Notwithstanding, the ApaI a/a genotype was a risk factor for SpA and AS in males. The FokI f/f genotype was associated with a better clinical activity in PsA. When considering the covariates, vitamin D sufficiency, and gender, the FokI F/F genotype was associated with a risk factor in males with SpA and AS compared with females with this same genotype. In conclusion, the ApaI rs7975232 polymorphism was associated with PsA, and the FokI rs2228570 polymorphism was associated with better clinical PsA activity. ApaI and FokI were associated with SpA and AS when considering gender and vitamin D sufficiency.

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Section: Discussionmentioning

confidence: 99%

The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis

Neves

Visentainer

Reis

et al. 2020

International Journal of Inflammation

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“…The association of HLA-B27 with spondyloarthritis varies markedly among different SpA and among different ethnic groups [41][42][43][44]. HLA-B*27, generally present in about 90% of patients with AS in non-mixed populations, was positive in 50% to 70% of the Brazilian and Ibero-American patients [43,44].…”

Section: Discussionmentioning

confidence: 99%

IL17F: A Possible Risk Marker for Spondyloarthritis in HLA-B*27 Negative Brazilian Patients

Neves

Visentainer

Reis

et al. 2021

JPM

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HLA-B*27 is an important marker for spondyloarthritis (SpA), however, many SpA patients are HLA-B*27 negative. Thus, the aim of this study was to investigate the influence of IL17, TNF and VDR gene polymorphisms in SpA patients who were HLA-B*27 negative. This case-control study was conducted in 158 patients [102 patients with ankylosing spondylitis (AS) and 56 with psoriatic arthritis (PsA)] and 184 controls. HLA-B*27 genotyping was performed using PCR-SSP and IL17A (rs2275913), IL17F (rs763780), TNF-308 (rs1800629), TNF-238 (rs361525), FokI C>T (rs2228570), TaqI C>T (rs731236), ApaI A>C (rs7975232), and BsmI C>T (rs1544410) using PCR-RFLP. Statistical analyses were performed by Chi-square and logistic regression using OpenEpi and SNPStats software. The IL17F C allele frequency was higher in patients with SpA, AS and PsA compared to controls. The IL17F T/C genotype frequency was higher in SpA patients in an overdominant inheritance model and when men and women were separately analyzed. IL17A_IL17F AC haplotype was significantly associated to the risk for SpA patients. As for VDR, the ApaI a/a was a potential risk factor for SpA in men. In conclusion, IL17F C variant contributed to the risk of SpA in Brazilian patients who were HLA-B*27 negative and could be a potential marker for SpA.

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HLA-B*27 – Frequency of clinical signs in Brazilian patients with spondyloarthritis

Cited by 2 publications

References 21 publications

The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis

The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis

IL17F: A Possible Risk Marker for Spondyloarthritis in HLA-B*27 Negative Brazilian Patients

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