HLA Associations of Intrathecal IgG Production against Specific Viruses in Multiple Sclerosis
Stephan Neidhart,
Benjamin Vlad,
Marc Hilty
et al.
Abstract:ObjectiveSpecific human leucocyte antigen (HLA) alleles are not only associated with higher risk to develop multiple sclerosis (MS) and other autoimmune diseases, but also with the severity of various viral and bacterial infections. Here, we analyzed the most specific biomarker for MS, that is, the polyspecific intrathecal IgG antibody production against measles, rubella, and varicella zoster virus (MRZ reaction), for possible HLA associations in MS.MethodsWe assessed MRZ reaction from 184 Swiss patients with … Show more
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