HLA association in aspirin-intolerant asthma

Choi, Jeong Hee; Lee, Kyung Wha; Oh, Heung Bum; Lee, Kwan Jeh; Suh, Young Joon; Park, Choon-Sik; Park, Hae‐Sim

doi:10.1016/j.jaci.2003.12.012

Cited by 74 publications

(36 citation statements)

References 7 publications

(3 reference statements)

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“…In addition, a SEA-specific IgE response may contribute to increased airway hyperresponsiveness, while a SEB-specific IgE response could contribute to increased peripheral eosinophil counts. Previous studies have reported that HLA allele DPB1*0301 is a strong marker for AERD because patients with this allele presented with an AERD phenotype, such as a decreased FEV 1 % and high comorbidity of CRS with nasal polyps [33,34,35]. In this study, no significant association between IgE sensitization to SEAs and the HLA-DBP*0301 allele was found.…”

Section: Discussioncontrasting

confidence: 58%

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Yoo¹,

Shin²,

Liu³

et al. 2013

Int Arch Allergy Immunol

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Background: Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated with eosinophilic inflammation and leukotriene production. However, the role of SAg-specific IgE in the pathogenesis of AERD is not well understood. We evaluated the clinical significance of serum IgE specific for three types of SAg, namely staphylococcal enterotoxins A and B (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1) in AERD. Methods: We enrolled 147 patients with AERD confirmed by a lysine-acetyl salicylic acid bronchoprovocative test and compared them with 147 patients with aspirin-tolerant asthma (ATA) and 141 healthy controls (NC). The levels of serum total IgE and SAg-specific IgE were measured using an ImmunoCAP system. Other clinical parameters were analyzed retrospectively. Results: The prevalences of SEA-, SEB- and TSST-1-specific IgE in the AERD and ATA groups were significantly higher than those in the NC group (p < 0.05, respectively). The total IgE level was significantly higher in patients with AERD with high levels of SEA-specific IgE than in those with lower levels (p < 0.05), with significant positive correlations between total and SAE-specific IgE levels (p < 0.05). The PC₂₀ methacholine level was significantly lower in patients with AERD with high levels of SEA-specific IgE, while a significantly higher eosinophil count was noted in patients with AERD with high levels of SEB-specific IgE (p < 0.05, respectively). Conclusions: Specific IgE responses to SAg may increase the serum total IgE level, airway hyperresponsiveness and eosinophil activation, leading to more severe clinical symptoms in AERD.

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Section: Discussioncontrasting

confidence: 58%

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Yoo¹,

Shin²,

Liu³

et al. 2013

Int Arch Allergy Immunol

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“…HLA-DBP1 *0301 has been proposed as an independent risk factor for the AERD phenotype19. The frequency of HLA-DPB1 *0301 was more prominent in AERD patients than in ATA patients19.…”

Section: Discussionmentioning

confidence: 99%

“…HLA-DBP1 *0301 has been proposed as an independent risk factor for the AERD phenotype19. The frequency of HLA-DPB1 *0301 was more prominent in AERD patients than in ATA patients19. The AERD patients who have HLA-DBP1 *0301 showed a higher requirement for leukotriene receptor antagonists for the management35.…”

Section: Discussionmentioning

confidence: 99%

“…High-resolution typing for HLA-DBP1*0301 was performed as previously described, using the amplified gene product of locus specific primers and direct sequencing with the ABI 3100 Genetic Analyzer (Applied Biosystems, Foster City, CA, USA)19. Genotyping of CYSLTR1 -634C > T gene polymorphism (rs321029) was performed as previously described, using a primer extension method with a SNaPshot ddNTP primer extension kit (Applied Biosystems)20.…”

Section: Methodsmentioning

confidence: 99%

“…The serum and urine samples from AERD and ATA patients were analyzed for SL metabolites using lipid chromatograpy- mass spectrometry. Additionally, we searched for a correlation between SL metabolites and key AERD biomarkers, 15-hydroxyeicosatetraenoic acid (15-HETE)18, human leukocyte antigen HLA-DBP1*0301 19, cysteinyl leukotriene receptor type 1 ( CYSLTR1) gene polymorphism20 and periostin21. To discriminate AERD from ATA, receiver operating characteristics (ROC) curve analysis for serum S1P and urine sphingosine were analyzed.…”

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confidence: 99%

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Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease

Trinh

Kim

Cho

et al. 2016

Sci Rep

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Sphingolipid (SL) metabolites have been suggested to be important inflammatory mediators in airway inflammation and asthma. However, little is known about SL metabolites in aspirin-exacerbated respiratory disease (AERD). We aimed to explore the potential AERD biomarkers by conducting lipidomics targeting SL metabolites. The levels of SL metabolites in serum and urine samples from 45 AERD patients and 45 aspirin-tolerant asthma (ATA) patients were quantified through mass spectrometry. During the lysine-aspirin bronchoprovocation test (ASA-BPT), the levels of serum sphingomyelin (SM) were significantly decreased in AERD (P < 0.05) but not in ATA. The serum SM levels were positively correlated with airway responsiveness to methacholine. At the basal status before the ASA-BPT, the levels of serum sphingosine-1-phosphate (S1P) and urine sphingosine were significantly higher in the AERD patients compared with that of ATA patients (P < 0.001) and were positively correlated with a greater decrease in FEV1 (%) values following the ASA-BPT test (P < 0.001 for each), and with serum periostin level (P < 0.05 for each). This study is the first to evaluate serum S1P and urine sphingosine as potential biomarkers of AERD as well as to examine the metabolic disturbance of SL in AERD patients.

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Hypersensitivity to Aspirin and Other Non-steroidal Anti-inflammatory Drugs

Dursun

Stevenson

2019

All Around the Nose

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HLA association in aspirin-intolerant asthma

Cited by 74 publications

References 7 publications

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Clinical Significance of Immunoglobulin E Responses to Staphylococcal Superantigens in Patients with Aspirin-Exacerbated Respiratory Disease

Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease

Hypersensitivity to Aspirin and Other Non-steroidal Anti-inflammatory Drugs

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