HLA antigens in malignant melanoma

Bergholtz, B. O.; Brennhovd, I. O.; Klepp, Olbjørn; Kaakinen, Aulikki; Thorsby, E.

doi:10.1002/1097-0142(197706)39:6<2342::aid-cncr2820390604>3.0.co;2-7

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…[4][5][6][7] Various associations between HLA type and NMSC risk have been noted in the non-immunosuppressed population (Cw3, DR1, DR7, DR4 and DR53), [19][20][21][26][27][28][29] as well as with MM (A9, B8, B27, B35, B40, B49, DR4 and DR5). [30][31][32][33][34][35] Negative associations have also been noted between NMSC and B17 (B58) and DR3, and MM and B7. In two separate studies in Melbourne, Australia, Czarnecki et al found HLA-DR4 to be associated with an increased risk of multiple BCC and MM, 28 as well as multiple BCC and SCC.…”

Section: Discussionmentioning

confidence: 99%

Celtic ancestry, HLA phenotype and increased risk of skin cancer

Long

Darke²,

Marks

1998

British Journal of Dermatology

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Individuals of Celtic ancestry are claimed to be at greater risk of skin cancer than non-Celts, and various positive and negative associations between certain human leucocyte antigen (HLA) phenotypes and the development of skin cancer have been described. The aims of this study were to determine whether any HLA phenotypes are associated either with Celtic or non-Celtic ancestry, or skin type. One thousand and ten members of the Welsh Bone Marrow Donor Registry (WBMDR), whose HLA phenotypes are known, were asked to complete a questionnaire which enquired as to their family origins and their 'Index of Celtic Ancestry' scored out of 12. Three groups were identified: non-Celts (score < 3), Celts (score > 9), and a subset of the Celts--'high scoring' Celts (score > 10). Details of hair and eye colour and skin type were also requested. Skin type and HLA-A, -B, -DR and -DQ frequencies were compared between the three groups (Celts, non-Celts and 'high scoring' Celts), and a random indigenous population of 9196 members of the WBMDR. Seven hundred and thirty-six replies were received (279 male, 457 female, mean age 31 years). One hundred and forty-four Celts, 51 'high scoring' Celts and 170 non-Celts were identified. Forty-six (32%) Celts had skin type I or II compared with 36 (21%) non-Celts (P = 0.039), and 37 (73%) 'high scoring' Celts had skin type I or II (P < 0.0001). However, there were no significant differences between the groups with regard to hair colour, eye colour or number of episodes of painful sunburn. The frequency of HLA-DR4 was 32% in the non-Celtic group, 44% in the Celtic group (not significant), and 53% in the 'high scoring' Celts (P = 0.008). However, the difference was not significant after correction. There were no significant associations between skin type and HLA phenotype. HLA-DR4 is known to be associated with an increased risk of both basal cell carcinoma and malignant melanoma and its increased frequency in Celts may be an independent risk factor for skin cancer in addition to skin type.

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Section: Discussionmentioning

confidence: 99%

Celtic ancestry, HLA phenotype and increased risk of skin cancer

Long

Darke²,

Marks

1998

British Journal of Dermatology

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“…The genetic restrictions for monocytes in antigen-specific antibody responses of human B cells have not been reported. In T-cell blastogenic responses to antigen stimulation, Bergholtz and Thorsby demonstrated the requirement for DR-compatible monocytes (35). In addition, Kurnick et al (11) have reported the requirement of APCs with shared HLA-D antigens for the continued proliferation of antigen-specific T cells in the presence of the appropriate soluble antigen.…”

Section: Methodsmentioning

confidence: 99%

Antigen-specific human T-cell clones: development of clones requiring HLA-DR-compatible presenting cells for stimulation in presence of antigen.

Sredni¹,

Volkman²,

Schwartz³

et al. 1981

Proc. Natl. Acad. Sci. U.S.A.

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A method for cloning soluble antigen-specific proliferating human T lymphocytes directly from peripheral blood cells of individuals recently primed with the antigen is described. The soluble antigen was keyhole limpet hemocyanin. After expansion in liquid culture, these cells were shown to be antigen specific and to require HLA-DR-histocompatible presenting cells. Re Cell Membrane Markers. Cloned cells were characterized for sheep erythrocyte receptors by a rosette procedure as described (24). In addition, assays for the presence of surface membrane immunoglobulin and complement receptors were performed on the cloned cells as described (24). Other membrane antigens were characterized by indirect immunofluorescence with two mouse monoclonal antibodies. The 3A1 antibody (25) delineates a major peripheral blood T-cell subset; the presence of Ia molecules was assessed by using a heterologous rabbit anti-p23,30 antiserum (gift of Dean Mann). Indirect immunofluorescence to detect cells binding these monoclonal antibodies was performed as described (25).TCGF. TCGF was produced as described by Morgan et at (5) and Ruscetti et al (4) 1858The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.

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“…No consistent pattern of inheritance, however, has been demonstrated. Attempts to show a population association between the HLA system and this disease have been largely inconclusive (Lamm et al 1974, Bergholtz et al 1976, La1 & Jorgensen 1976. We report a large kindred with multiple cases of malignant melanoma in which susceptibility to the disease is apparently inherited in an autosomal dominant manner and segregates with the HLA complex.…”

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confidence: 99%