HLA antigens in childhood onset schizophrenia

Jacobsen, Leslie K.; Mittleman, Barbara; Kumra, Sanjiv; Lenane, Marge; Barracchini, Kathleen C.; Adams, Sharon; Simonis, Toni B.; Lee, Paul R.; Long, Robert T.; Sharp, Wendy; Sidransky, Ellen; Ginns, Edward I.; Rapoport, Judith L.

doi:10.1016/s0165-1781(98)00015-8

Cited by 14 publications

(5 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increased frequency of HLA-A10, -A11, and -A29 and a decreased frequency of HLA-A2 were observed in a study involving adult patients with schizophrenia. 62 However, no significant association of HLA class I (HLA-A, -B, -C) and class II (HLA-DR, -DQ, -DP) antigens was found in a study of patients with childhood-onset schizophrenia 63 or in two studies of HLA-A alleles and schizophrenia in Japanese patients. 64,65 A study of a large Irish family with several cases of schizophrenia demonstrated a lack of association between HLA alleles and development of the disease.…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

The Case for Autoimmunity in the Etiology of Schizophrenia

Goldsmith

Rogers

2008

Pharmacotherapy

View full text Add to dashboard Cite

The treatment of schizophrenia has frustrated clinicians for over 50 years. Despite advances in neurotransmitter identification and the development of drugs targeting these transmitters, total remission of the disease is not always achieved. Potential etiologies other than neurotransmitter dysfunction merit consideration. One intriguing concept is the possible contribution of autoimmunity in patients with the disease. This breakdown of self-tolerance has been implicated in patients with other chronic diseases, such as type 1 diabetes mellitus and myasthenia gravis. The literature on autoimmunity as a possible mechanism in the pathogenesis of schizophrenia can be conflicting, but there is a substantial amount of circumstantial, although not conclusive, evidence of immune dysfunction in patients with schizophrenia.

show abstract

Section: Genetic Susceptibilitymentioning

confidence: 99%

The Case for Autoimmunity in the Etiology of Schizophrenia

Goldsmith

Rogers

2008

Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…16 The association between HLA and the severe form of schizophrenia, which has its onset in childhood and may cause several cognitive and behavioral sequelae, has not been confirmed. 17 Besides onset age, HLA has not been associated with gender of schizophrenic patients either. 18 Association of HLA with the season in which the patient with the disorder was born seems to be controversial.…”

Section: Schizophreniamentioning

confidence: 95%

Influência dos antígenos de histocompatibilidade humanos na susceptibilidade e expressão clínica de doenças psiquiátricas

Alves

Souza

Toralles

et al. 2006

Rev. psiquiatr. Rio Gd. Sul

View full text Add to dashboard Cite

A compreensão da base molecular das doenças é cada vez mais importante para seu diagnóstico, prevenção e tratamento. Localizado no braço curto do cromossomo 6, o sistema de histocompatibilidade humano - human leukocyte antigen (HLA) - participa da patogênese de algumas enfermidades psiquiátricas. O surgimento de métodos moleculares para tipificação dos alelos HLA e as recentes atualizações de sua nomenclatura têm contribuído para um melhor entendimento desse sistema. Infelizmente, essas informações não têm sido adequadamente veiculadas na literatura clínica. São objetivos desse trabalho: revisar a estrutura e função dos antígenos HLA, métodos de tipificação e nomenclatura atual e descrever seus mecanismos de associação com esquizofrenia, transtorno bipolar do humor e autismo. Foram pesquisados, através das bases de dados MEDLINE e LILACS, artigos publicados no período de 1995 a 2005, a fim de refletir o conhecimento mais recente sobre o assunto. Conclui-se que os antígenos de histocompatibilidade humanos influenciam o risco, quadro clínico e resposta terapêutica de algumas doenças psiquiátricas, mesmo não sendo eles os únicos atuantes no processo patológico. Embora o HLA tenha sido associado com esquizofrenia (HLA-DRB1*0101), autismo (HLA-DR4) e transtorno bipolar do humor (HLA de classe I), essas associações variam entre diferentes etnias e formas clínicas das doenças. A melhor definição de marcadores genéticos associados a distúrbios psiquiátricos é importante para elucidar possíveis mecanismos envolvidos na sua patogenia, estimar o risco individual de desenvolver essas doenças e contribuir para futuras intervenções profiláticas ou terapêuticas.

show abstract

“…The frequency of COS is reported to be less than 1 case in 10,000-30,000 children. There is an extreme paucity of immunological studies in COS [14,15]. High blood titers of PAA in this group of patients have been investigated and reported in our previous study [16].…”

Section: Introductionmentioning

confidence: 94%

Effect of Clozapine and Other Antipsychotics on the Level of Platelet-Associated Autoantibodies in Children with Schizophrenia: A Longitudinal Follow-Up Study

Ebert¹,

Schechtman

Midbari

et al. 2015

Neuropsychobiology

View full text Add to dashboard Cite

Background: Previous studies have demonstrated significantly higher blood titers of platelet-associated autoantibodies (PAA) in adult schizophrenia patients compared to normal healthy subjects. In addition, young adult schizophrenia patients at their early stages of the disorder displayed higher PAA titers than older patients with longer duration of the disorder. Aim: To assess longitudinally the blood titers of PAA in inpatients with childhood-onset schizophrenia at admission, after short- and long-term follow-up, and the correlation of these titers with the response to clozapine and other antipsychotic treatments. Methods: Thirty children, age range of 6-12 (mean ± SD: 9.6 ± 1.5 years), with DSM-IV TR schizophrenia in active psychotic state were assessed 3 times: at baseline, after short-term (8-17 weeks; n = 26) and after long-term follow-up (33-170 weeks; n = 19). The blood titers of PAA were analyzed using ELISA and expressed by a linear optical density (OD) scale. A test recording >1.4 OD units was predefined as the positive cutoff value. Results: On long-term follow-up, 9 out of the 17 children who were PAA-positive at baseline became PAA-negative: 7 already after 2 months of clozapine treatment and 2 following 3 years of risperidone treatment. Eight children remained PAA-positive during the entire study period. There was no significant correlation between the clinical improvement (as assessed by change in the Positive and Negative Syndrome Scale score) and the alteration in PAA levels (n = 19, r = -0.4, p = 0.088). Conclusions: High rates of positive PAA in COS patients may indicate an active autoimmune process in early-onset schizophrenia. It is concluded that PAA may serve as a biomarker for the diagnosis of COS, but does not predict the response to treatment. A transition to a PAA-negative status does not indicate an improvement in psychosis.

show abstract

HLA antigens in childhood onset schizophrenia

Cited by 14 publications

References 74 publications

The Case for Autoimmunity in the Etiology of Schizophrenia

The Case for Autoimmunity in the Etiology of Schizophrenia

Influência dos antígenos de histocompatibilidade humanos na susceptibilidade e expressão clínica de doenças psiquiátricas

Effect of Clozapine and Other Antipsychotics on the Level of Platelet-Associated Autoantibodies in Children with Schizophrenia: A Longitudinal Follow-Up Study

Contact Info

Product

Resources

About