HLA Antigens in Borderline and Essential Hypertension

Titkov, Yuri S.; Ziskina, Renate A.; Темиров, А. А.; Gybladze, David V.; Бубнова, Л. Н.

doi:10.1093/ajh/6.10.885

Cited by 9 publications

(4 citation statements)

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“…A review of the literature up to 1989 was presented in a previous publication. 1 Since then, an association with HLA-B18 was reported in Russian patients, 2 as previously reported in French 3 and Canadian 4 patients. An association with HLA-DR4 was detected in Brazilian patients, 5 and with HLA-DR2 in North Chinese patients.…”

supporting

confidence: 59%

Human Leukocyte Antigens and Malignant Essential Hypertension

Gerbase‐DeLima

Paiva

Bortolotto

et al. 1998

American Journal of Hypertension

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The purpose of this study was to investigate an association between human leukocyte antigens (HLA) and the susceptibility to malignant hypertension. The presence of HLA-A, -B, -DR, and -DQ was determined in 33 white and in 23 mulatto Brazilian patients with malignant essential hypertension. No statistically significant differences were detected between patients and control subjects. It is nevertheless important to note that we have observed an increased frequency of DR3 in the mulatto patients (34.8% v 21.4%). We consider that this finding supports the existence of an HLA-DR3 association with hypertension in the black population, as has been claimed by other authors. Am J Hypertens 1998;11:729 -731

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supporting

confidence: 59%

Human Leukocyte Antigens and Malignant Essential Hypertension

Gerbase‐DeLima

Paiva

Bortolotto

et al. 1998

American Journal of Hypertension

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“…One of the genetic systems for which a possible relationship with EH has been considered is the HLA system and this has been documented in linkage studies. 2,3 However, studies to analyse the possible association between EH and antigens or alleles of the HLA system, mainly HLA-B and HLA-DR, [3][4][5][6][7][8] have failed to yield consistent results.…”

Section: Introductionmentioning

confidence: 99%

Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)

Zabay¹,

Marco

Soler³

et al. 2005

J Hum Hypertens

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Separate studies investigating the relationship of essential hypertension (EH) with the HLA system and with Chlamydia pneumoniae (C. pneumoniae) infection have given conflicting results. Our aim was to clarify these relationships and determine whether the HLA system and C. pneumoniae infection interact with respect to the risk for EH. An association study (110 essential hypertensives and 107 controls) was conducted in a highly homogeneous population in the Balearic Island of Majorca (Spain). Molecular typing of HLA-B and HLA-DRB and quantification of serum levels of IgG antibodies to C. pneumoniae (sIgGa-Cp) were determined. Student's t-test, v 2 -statistics, logistic regression analysis, and general linear model ANOVA were used for statistical analysis. The results showed that EH was related with HLA-DRB3*0202 in the whole study population, and with levels of sIgGa-Cp463.5 BU/ ml in the group of individuals with sIgGa-Cp430 BU/ml (OR (95% CI) adjusted for obesity, familial history of EH and diabetes ¼ 2.06 (1.07-3.97), P ¼ 0.03, and ¼ 4.60 (1.06-19.90), P ¼ 0.04, respectively). The association between EH and sIgGa-Cp was observed in the DRB3*0202( þ ) individuals, but not in the DRB3*0202(À) subgroup (OR (95% CI) ¼ 11.14 (1.92-64.54), P ¼ 0.004, and ¼ 0.98 (0.22-4.43), P ¼ 0.64, respectively (P of the Mantel-Haenszel test for homogeneity of OR ¼ 0.06)). In our population, EH was positively associated with HLA-DRB3*0202 and with high levels of sIgGa-Cp. Moreover, a significant interaction of DRB3*0202 on the effect of sIgGa-Cp was observed, as the association of EH with these antibodies depended on the presence of DRB3*0202.

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“…The MHC genes themselves may be considered candidates as the immune system of the SHR is dysfunctional and hypertension in the SHR strain appears to have an autoimmune component 20 . Furthermore, there are alterations in MHC antigen frequencies in human hypertension 21 …”

Section: Discussionmentioning

confidence: 99%

COSEGREGATION OF THE Tnfα LOCUS WITH CARDIOVASCULAR PHENOTYPES IN THE F₂ GENERATION OF A NEW ZEALAND GENETICALLY HYPERTENSIVE AND BROWN NORWAY CROSS

Harris¹,

Grigor

Thompson

1998

Clin Exp Pharma Physio

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1. The association of the Tnfalpha locus with several cardiovascular phenotypes and body mass has been studied in the F2 generation of a reciprocal cross between rats of the New Zealand genetically hypertensive (GH) and the normotensive Brown Norway (BN) strains. In the total F2 population the GH allele of Tnfalpha cosegregated with increased intra-arterial blood pressure (BP) in a recessive manner. A similar but weaker effect was observed for tail BP. 2. An association between genotype and body mass in females with GH grandfathers was also detected. 3. An association between genotype and pulse rate was observed for females. 4. This work supports other evidence pointing to an association of a gene (or genes) on rat chromosome 20 with hypertension.

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HLA Antigens in Borderline and Essential Hypertension

Cited by 9 publications

References 0 publications

Human Leukocyte Antigens and Malignant Essential Hypertension

Human Leukocyte Antigens and Malignant Essential Hypertension

Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)

COSEGREGATION OF THE Tnfα LOCUS WITH CARDIOVASCULAR PHENOTYPES IN THE F₂ GENERATION OF A NEW ZEALAND GENETICALLY HYPERTENSIVE AND BROWN NORWAY CROSS

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HLA Antigens in Borderline and Essential Hypertension

Cited by 9 publications

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Human Leukocyte Antigens and Malignant Essential Hypertension

Human Leukocyte Antigens and Malignant Essential Hypertension

Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)

COSEGREGATION OF THE Tnfα LOCUS WITH CARDIOVASCULAR PHENOTYPES IN THE F2 GENERATION OF A NEW ZEALAND GENETICALLY HYPERTENSIVE AND BROWN NORWAY CROSS

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COSEGREGATION OF THE Tnfα LOCUS WITH CARDIOVASCULAR PHENOTYPES IN THE F₂ GENERATION OF A NEW ZEALAND GENETICALLY HYPERTENSIVE AND BROWN NORWAY CROSS